DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF64C and Fgd4

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_001288746.1	Gene:	Fgd4 / 224014	MGIID:	2183747	Length:	887	Species:	Mus musculus

Alignment Length:	662	Identity:	124/662 - (18%)
Similarity:	226/662 - (34%)	Gaps:	190/662 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1394 SEHHYESIRHSGDPIYEEIHEVPPPLPLSAPPLNDAELEKKAAR-----SIFEGASKYDILSYLV 1453
            |.|..:..||...|..:...|...|.|.|...      :.|.::     |.|||.|   :||..:
Mouse   103 SSHIPQVPRHKALPSAKPRMEESNPAPTSCTS------KGKHSKVSDLISHFEGGS---VLSSYI 158

  Fly  1454 DAKERGLAREESFDYGNNPKIIEEEAADTLSDLDKR--------QAEERERDRDSGQ-------- 1502
            |     |.::.:.:. |.|:.:.:..   |:....|        |.:|.:.|:..||
Mouse   159 D-----LQKDSTMNL-NIPQTLGQPG---LTSSPPRKFLPQHSPQKQENDPDQTQGQHGCLANGV 214

  Fly  1503 -----------SSMSSLSP---------PPHNFICGGAGKSSGSDVERQDSGVGSETSKTSRSKY 1547
                       ...::|||         .|...:..|....:.:|.....:....|.:..|..:.
Mouse   215 VAAQNQMECEDEKETTLSPEMAIQTAAASPDTHVLNGERNETITDSASSIANSHDENASDSSCRT 279

  Fly  1548 QATPTVLHLCEDCDGA-VEMQVGDNGILYAPLVCRKCG----------KKRVERK--EIITEIVE 1599
            ..|...|...|...|. .|:|..:||:       ...|          |:..|:|  :|.||::.
Mouse   280 PGTDLGLPSKEGEPGMDAELQERENGV-------NTMGLDTLDQHHEVKETNEQKLHKIATELLL 337

  Fly  1600 TEEKYGRDLQIILEEFCHPMLV---AGLLTQEQLSAIFLNTEDLLENNQTLAERMRDALDMSLEQ 1661
            ||..|...|.::.:.|...:|.   .|....|.::.||.|...:   |...::.:...|:..:::
Mouse   338 TERAYVSRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSI---NAFHSKFLLPELEKRMQE 399

  Fly  1662 GDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLANLEKEKELLRI-------FLKVSQ-- 1717
            .:   .|..||.|.......|..:..|          :...:...||::.       |..|::
Mouse   400 WE---TTPRIGDILQKLAPFLKMYGEY----------VKGFDNAVELVKTMTERVPQFKSVTEEI 451

  Fly  1718 MENAVLRRMNLNSFLMVPVQRVTKYPLLLA-RLYKVTPSHLEGRELLKQAQEKIELHLNHINQEA 1781
            .:..:...:.|...::.|:||:.:|.:||. .|.|::|...:..: .|::.|.|....:|.|...
Mouse   452 QKQKICGSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSPDSPDWND-AKKSLEIISTAASHSNSAI 515

  Fly  1782 KDVPTKLWRRISSSSPNRRASCEIDMINIKLRKMAIDVLEWNHDEVRFAMEGRLLYTQPTDSNWK 1846
            :                       .|.|:|......::|....|.|           .|::...|
Mouse   516 R-----------------------KMENLKKLLEIYEMLGEEEDIV-----------NPSNELIK 546

  Fly  1847 KARTIKLTPVNALLVTNGKPSANYRAEKAMSEKLNFPKHTGIREASLLLVKEK---C-GRYTL-- 1905
            :.:.:||.                            .::|..:|..|.|....   | .|::|
Mouse   547 EGQILKLA----------------------------ARNTSAQERYLFLFNNMLLYCVPRFSLVG 583

  Fly  1906 ----IREPLYLDRCVVCSEADWDDYFEVQEISSKD-TFIFKAEDGVRTKQWYTQLQYHAQGMGAW 1965
                :|..:.:|...:. |...::|....:||.|: |...:|......::|...||   :.:.|:
Mouse   584 SKFTVRTRVGIDGMKIV-ETHNEEYPHTFQISGKERTLELQASSEQDKEEWIKALQ---ESIDAF 644

  Fly  1966 RKR----RNALA 1973
            .:|    |||:|
Mouse   645 HQRHETFRNAIA 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	40/198 (20%)
Fgd4	NP_001288746.1	RhoGEF	331..512	CDD:279015	40/197 (20%)
		PH	544..641	CDD:278594	22/128 (17%)
		PH1_FDG4	544..637	CDD:275434	20/121 (17%)
		FYVE_FGD1_2_4	675..739	CDD:277280
		PH2_FGD1-4	758..860	CDD:270056
		PH	776..860	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900