DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF64C and Arhgef19

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_001366576.1	Gene:	Arhgef19 / 213649	MGIID:	1925912	Length:	802	Species:	Mus musculus

Alignment Length:	910	Identity:	171/910 - (18%)
Similarity:	289/910 - (31%)	Gaps:	327/910 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1131 PINTPPVISSTPATP-----------------PPTDLPIENANPLVPHETELLKILRNPVEAVKL 1178
            |....|.::..|.|.                 ||:.|.:: ..|:.|.|      |:.|.....|
Mouse     6 PATLQPHLAGPPGTARRPVAVCQQESLSFVELPPSRLCVD-LFPIAPEE------LQAPGSRWSL 63

  Fly  1179 NLVPHVCGLRAPTRESGKSKKIQEEEVSGTPVKDPGFIAKLLQDPMLGQVAEGLETETVAELIEN 1243
            .....:.||..||...|....|    .|.:....||........|       |.:..|:.|  ..
Mouse    64 ATPAPLQGLLWPTSPGGPDTHI----ASTSGGMRPGRAGSWPHCP-------GAQPPTLVE--PW 115

  Fly  1244 SLQRLQQARRGIDMSGTKDHDDMNRLISASLQRIRLERQPATPGISATKEEDRLSNRGSISSA-N 1307
            |.|.:|..||.                                           |:.||..|| .
Mouse   116 SSQHMQPQRRA-------------------------------------------SHSGSEKSAWR 137

  Fly  1308 SFASAHNYELFDFDGGAGGNESDCYQSCSSELTASGILE------EDSVSPIKDPETE------- 1359
            .....||.|       |.|.|           |.:|:||      |.::..::....|
Mouse   138 KMQVYHNEE-------ATGTE-----------TPTGLLETGQAAQEQALCALEPGPQELSGNARG 184

  Fly  1360 -LDAATRAKFYQLLVDATLAEIEHSTHMDQTLGTD---------------------------SEH 1396
             |:|..|.:|       :.:|:....|....||..                           :|.
Mouse   185 GLEAPERRRF-------SASELMTRLHSSLRLGRSTATRVLTSGSGAGAIREGKLPVRESRRAET 242

  Fly  1397 HYESIRHSGDPIYEEIHE--VPPPLPLSAPPLND--AELEKKAARSIFEGASKYDILSYLVDAKE 1457
            ..:|:...|.....|:|.  |.|.|.....|..|  :..|::.:|             :|:::
Mouse   243 RADSVSLPGPVDLNEVHGGLVEPRLDTQDKPTQDPSSATERRQSR-------------FLLNS-- 292

  Fly  1458 RGLAREESFDYGNNPKIIEEEAADTLSDLD-KRQAEERERDRDSGQSSMSSLSPPPHNFICGGAG 1521
                            ::.:|.:|..|..: :||..|.|...|..:.:.....||..|.
Mouse   293 ----------------VLYQEYSDVASARELRRQQREEEGPGDGAEGAEEGPGPPRANL------ 335

  Fly  1522 KSSGSDVERQDSGVGSETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPLVCRKCGKK 1586
             |..|....|.|..||     :.|.:|..|               .|..:|:| |.|..|.|
Mouse   336 -SPSSSFRAQRSTRGS-----TFSLWQDIP---------------DVRGSGVL-ATLSLRDC--- 375

  Fly  1587 RVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTED------LLENNQ 1645
              :.:|...|::.:|..|...|.:.:..|         |...:||.. |.|:|      .|...:
Mouse   376 --KLQEAKFELITSEASYIHSLSVAVGHF---------LGSVELSEC-LGTQDKQWLFSKLPEVK 428

  Fly  1646 TLAERMRDALDMSLEQGDDDLLTVNI-----------GRIFLDF-TQMLHAFESYCVRQAGASLL 1698
            :.:||....|:..||.   |:|..::           .|::|.: |...:...:|      ..||
Mouse   429 STSERFLHDLEQRLEA---DVLRFSVCDVVLHHCPAFRRVYLPYVTNQAYQERTY------QRLL 484

  Fly  1699 LANLEKEKELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELL 1763
            |.|.:....|.|:      .|:.|.:|:.|.|||::|.||||:..:|:..:.|.|..
Mouse   485 LENPKFPGILARL------EESPVCQRLPLTSFLILPFQRVTRLKMLVENILKRTAP-------- 535

  Fly  1764 KQAQEKIELHLNHINQEAKDVPTKLWRRISSSSPNRRASCEIDMINIKLRKMAIDVLEWNHDEVR 1828
                          ..:.:|:.||.:    |:.......|...:.::|..:..|      |...:
Mouse   536 --------------GSQDEDMATKAF----SALKELVQECNASVQSMKRTEELI------HLSKK 576

  Fly  1829 FAMEGRLLYTQPTDSNW--KKARTIKLTPVNALLVTNGKPSANYR-AEKAMSEKLNFPKHTGIRE 1890
            ...||: ::...:.:.|  :....::|.|:.|      .|.|..: :.||:...|       ..:
Mouse   577 IHFEGK-IFPLISQARWLVRHGELVELAPLPA------APPAKLKLSSKAVYLHL-------FND 627

  Fly  1891 ASLLLVKEKCGRYTLIREPLYLDRCVVCSEADWDDYFEVQEISSK------DTFIFKAEDGVRTK 1949
            ..||..:::.|::.:.         |..:.|:    .:|:::|.|      ..|:.:...|.|.:
Mouse   628 CLLLSRRKELGKFAVF---------VHANMAE----LQVRDLSLKLQGIPGHVFLLRLLHGQRAR 679

Fly 1950 1949
Mouse 680 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	44/203 (22%)
Arhgef19	NP_001366576.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..136		18/114 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..192		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..286		11/67 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..343		10/42 (24%)
		RhoGEF	382..558	CDD:395496	48/226 (21%)
		PH_ephexin	580..706	CDD:269929	22/127 (17%)
		SH3	719..773	CDD:418401
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900