DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF64C and Itsn2

DIOPT Version :10

Sequence 1:NP_729032.1 Gene:RhoGEF64C / 38578 FlyBaseID:FBgn0035574 Length:1984 Species:Drosophila melanogaster
Sequence 2:NP_001185897.1 Gene:Itsn2 / 20403 MGIID:1338049 Length:1685 Species:Mus musculus


Alignment Length:1846 Identity:325/1846 - (17%)
Similarity:579/1846 - (31%) Gaps:600/1846 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   375 NVAAIAGQRISLGDKSGDSSDP------GDSYERIIMVSGGESTASNGPRRPPRNKKADEPAEMP 433
            |:.||..:..:..||..|:..|      ||......:.||                       :|
Mouse    14 NMWAITSEERTKHDKQFDNLKPSGGYITGDQARTFFLQSG-----------------------LP 55

  Fly   434 AAAGAAGAAGAAATSPPAAAVTAATAVKPKAVTLAKVEKIEKDNESAYTV--------LTVTPTS 490
            |              |..|.:.|          |:.:.|..|.::..:::        |......
Mouse    56 A--------------PVLAEIWA----------LSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLP 96

  Fly   491 PAIKSILKRPTTLELP------GVGMSP-----LPLPPVNNSGLVTP--AGKSQFYIP------- 535
            ..:..|:|:|.... |      |:|..|     .|||||  :.:.||  :..|...||       
Mouse    97 VVLPPIMKQPPMFS-PLISARFGMGSMPNLSIHQPLPPV--APIATPLSSATSGTSIPPLMMPAP 158

  Fly   536 ---------TPTGTAATPTSSSTPMATSTPTPNASITATTAAAGAAITPGSRKKVQFMVE-DKII 590
                     .|.|||:.....|.|.::||....:|.:......|.|    |.:|.|.::: ....
Mouse   159 LVPSVSTSSLPNGTASLIQPLSIPYSSSTLPHASSYSLMMGGFGGA----SIQKAQSLIDLGSSS 219

  Fly   591 ATTATAATTDDSDAS-----AVATKTNYEY---YNRKRNAATATAAAATAASAAAASPPTAATST 647
            :|::||:.:.:|..:     ||...:..:|   :|......:...:...|.:|...|     ..:
Mouse   220 STSSTASLSGNSPKTGTSEWAVPQPSRLKYRQKFNSLDKGMSGYLSGFQARNALLQS-----NLS 279

  Fly   648 DQQEATLFA-ADIDDEHNFTTSGEAAPPFIKPDSLHYEDVLPGPQIFDSSESSAKLSLPADGSPH 711
            ..|.||::. ||||.:...     .|..||.  ::|..|:             ||.     |.|.
Mouse   280 QTQLATIWTLADIDGDGQL-----KAEEFIL--AMHLTDM-------------AKA-----GQPL 319

  Fly   712 VTTSPVSVLPTGTSNG--VGGA-GLGPGPAGVSGEEAPATAAATAAATQKTT------------- 760
            ..|.|..::|.....|  |... |..|.......||.......|....:|..             
Mouse   320 PLTLPPELVPPSFRGGKQVDSVNGTLPSYQKTQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQ 384

  Fly   761 --AANRDYDDDDEHNDKDESHDNKPNDLAEREQDREGDKEQGRAGELGISRQ---------EKKD 814
              ...:..:.:.:...:.|..:.|..:|.|:|..::.:.|:....:..:.||         |:::
Mouse   385 VLMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKEIERRE 449

  Fly   815 AGGKPAASQKR-----------AAQTTQSRNPIRRAHSERHLSTAPLAAHGHASSACAAGRNCHS 868
            |..:....|:|           .:|.|:.:..|.|..|.:......|.|                
Mouse   450 AAKQELERQRRLEWERLRRQELLSQKTREQEDIVRLSSRKKSLHLELEA---------------- 498

  Fly   869 IPMTPPASGPQNVILNFKDTMALRIKSNRSDSRDLFQRRPTEPPPPPPPKGAGKGLEPLPHEINK 933
                  .:|....|......:.:|.::.:::...|.::...|.          ..::.|..|:.:
Mouse   499 ------VNGKHQQISGRLQDVQIRKQTQKTELEVLDKQCDLEI----------MEIKQLQQELKE 547

  Fly   934 SPLSPQRTVVRVAPFKPQQQQVGGSGDGFTHEVHRLKISHSEEDADLGVELRRRPNLFLSSPGEE 998
            .    |..::.:.|.|....:             |:|........|.|:.|..:.    ||..||
Mouse   548 Y----QNKLIYLVPEKQLLNE-------------RIKNMQLSNTPDSGISLLHKK----SSEKEE 591

  Fly   999 ---------DAAPKKTSILISGDDCYSTMNLSANAAQPLYQSSVVVNSHSATSVCIS-------- 1046
                     ||..|:|:..:|..|.::......:....:.|..:.:.|      |::        
Mouse   592 LCQRLKEQLDALEKETASKLSEMDSFNNQLKCGSMDDCVLQCLLSLLS------CLNNLFLLLKE 650

  Fly  1047 -VSSAEEQEQELNQLNTLRSQQMGMGIAIIPIRGASEVNLQRSVSCISSTSSSSTSSSSSSSGR- 1109
             ..|...|:..|.||:.::..::            .|:..:| :..|........::..:..|: 
Mouse   651 LRESYNTQQLALEQLHKIKRDKL------------KEIERKR-LEQIQKKKLEDEAARKAKQGKE 702

  Fly  1110 --GRTLIRLDYDRERKGSATSSTPINTPPVISSTPATPPPTDLPIENANPLVPHET--------- 1163
              .|..||.:.:.::|......:...|........|....|...:.|...|.|.|.         
Mouse   703 NLWRESIRKEEEEKQKRLQEEKSQDKTQEEERKAEAKQSETASALVNYRALYPFEARNHDEMSFS 767

  Fly  1164 --ELLKILR----------------------NPVEAV---------KLNLVPHVCGLRAPTRESG 1195
              :::::..                      |.||.|         |..|:|....|.|.:..|.
Mouse   768 SGDIIQVDEKTVGEPGWLYGSFQGKFGWFPCNYVEKVLSSEKALSPKKALLPPTVSLSATSTSSQ 832

  Fly  1196 KSKKIQ----------------EEEVSGTPVKDPGFIAKLLQDPMLGQVAEGLETE--------- 1235
            ....:.                :::.:.|....||.::.:...   ||..|.|:.:         
Mouse   833 PPASVTDYHNVSFSNLTVNTTWQQKSAFTRTVSPGSVSPIHGQ---GQAVENLKAQALCSWTAKK 894

  Fly  1236 ------------TVAELIEN---------------SLQRL---QQARRGIDMSGTKDHDDMNRLI 1270
                        ||.|..||               |..:|   .:.:||          :...|.
Mouse   895 ENHLNFSKHDVITVLEQQENWWFGEVHGGRGWFPKSYVKLIPGNEVQRG----------EPEALY 949

  Fly  1271 SASLQRIRLERQPATPGISATKEE-DRLSNRGSISSAN-SFASAHNYELFDFDG----GAGGNES 1329
            :|..::......|.|.......|: ..|.:..|:...: :|.......:...||    |:.|.. 
Mouse   950 AAVTKKPTSTAYPVTSTAYPVGEDYIALYSYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGER- 1013

  Fly  1330 DCYQSCSSELTASGILEEDSVSPIKDPE----TELDAATRAKFYQLLVDATLAEIEHSTHMDQTL 1390
                        :||...:.|.| ||.|    .....|:..|          .||...|......
Mouse  1014 ------------TGIFPSNYVRP-KDQENFGNASKSGASNKK----------PEIAQVTSAYAAS 1055

  Fly  1391 GTDSEHHYESIRHSGDPIYEEIHEVPPPLPLSAPPLNDAELEKKAARSIFEGASKYDILSYLVDA 1455
            ||                 |::...|..|.|         :.||.....::|           :.
Mouse  1056 GT-----------------EQLSLAPGQLIL---------ILKKNTSGWWQG-----------EL 1083

  Fly  1456 KERGLAREESFDYGNNPKIIEEEAADTLSDL----------DKRQAEERERDRDSGQ--SSMSSL 1508
            :.||..|::.:...::.|::...:..|:...          |.....|.|.:...||  :.|:..
Mouse  1084 QARGKKRQKGWFPASHVKLLGPSSERTMPTFHAVCQVIAMYDYMANNEDELNFSKGQLINVMNKD 1148

  Fly  1509 SPP-------------PHNFICGGAGKSSGSDVERQDSGVGSETSKTSRSKYQATPTVLHLCEDC 1560
            .|.             |.|::    ..::.||..:|                        .|.|.
Mouse  1149 DPDWWQGETNGLTGLFPSNYV----KMTTDSDPSQQ------------------------WCADL 1185

  Fly  1561 DGAVEMQVGDNGILYAPLVCRKCGKKRVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLL 1625
            .....||..:.                 :|:..|.|:::|||:|..|||:::|.|...|..:|.|
Mouse  1186 QALDTMQPTER-----------------KRQGYIHELIQTEERYMDDLQLVIEVFQKRMAESGFL 1233

  Fly  1626 TQEQLSAIFLNTEDLLENNQTLAERMRDALDMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCV 1690
            |:..::.||:|.::|:.:|..|..    ||.:..:.|.:.:....||.|.......:.|:..:|.
Mouse  1234 TEADMALIFVNWKELIMSNTKLLR----ALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCS 1294

  Fly  1691 RQA-GASLLLANLEKEKELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTP 1754
            .|. ||:||....:::.:......|::  .:...:.|.|:|||:.|:||:|:||||:..:.:.||
Mouse  1295 CQLNGATLLQQKTDEDTDFKEFLKKLA--SDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTP 1357

  Fly  1755 -SHLEGRELLKQAQEKIELHLNHINQEAKDVPTKLWRRISSSSPNRRASCEIDMINIKLRKMAID 1818
             ||:: ...||.|.|:.|...:.:|:..::                              |...|
Mouse  1358 QSHVD-HSSLKLALERAEELCSQVNEGVRE------------------------------KENSD 1391

  Fly  1819 VLEWNHDEVRFAMEG---RLLYTQPTDSNWKKARTIKLTPVNALLVTNGKPSANYRAEKAMSEKL 1880
            .|||....|:  .||   :|::...|               |.|     .|.....:.|....|.
Mouse  1392 RLEWIQAHVQ--CEGLAEQLIFNSLT---------------NCL-----GPRKLLHSGKLYKTKS 1434

  Fly  1881 NFPKHTGIREASLLLV-----------------KEKCGRYTLIREPLYLDRCVVCSEADWDDYFE 1928
            |...|..:....|||.                 .:...::.:.:.|::|:..:|....|......
Mouse  1435 NKELHAFLFNDFLLLTYLVRQFAAASGHEKLFNSKSSAQFRMYKTPIFLNEVLVKLPTDPSSDEP 1499

  Fly  1929 VQEISSKDTFIFKAEDGVRTKQWYTQ 1954
            |..||..|.......|.:..:..:.|
Mouse  1500 VFHISHIDRVYTLRTDNINERTAWVQ 1525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF64CNP_729032.1 RhoGEF 1590..1778 CDD:238091 58/189 (31%)
Itsn2NP_001185897.1 EH 15..107 CDD:197477 21/138 (15%)
Atrophin-1 <86..>196 CDD:460830 27/112 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 220..242 5/21 (24%)
EH 238..317 CDD:197477 21/108 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..382 8/46 (17%)
PTZ00121 <347..764 CDD:173412 71/488 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 716..742 3/25 (12%)
SH3_Intersectin2_1 747..803 CDD:212921 6/55 (11%)
SH3_Intersectin2_2 883..934 CDD:212923 6/50 (12%)
SH3_Intersectin2_3 973..1024 CDD:212925 10/63 (16%)
SH3_Intersectin2_4 1045..1103 CDD:212927 15/94 (16%)
SH3_Intersectin2_5 1118..1171 CDD:212929 9/56 (16%)
RhoGEF 1202..1382 CDD:214619 57/186 (31%)
PH_13 1400..1543 CDD:465218 25/148 (17%)
C2_Intersectin 1543..1677 CDD:176021
Blue background indicates that the domain is not in the aligned region.

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