Protein Alignment RhoGEF64C and prhg-1

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: NP_001122556.1
• Gene: prhg-1 / 190810
• WormBaseID: WBGene00022391
• Length: 628
• Species: Caenorhabditis elegans
• Alignment Length: 616
• Identity: 113/616 - (18%)
• Similarity: 201/616 - (32%)
• Gaps: 217/616 - (35%)

  Fly  1476 EEEAADTL----SDLDKRQA----EERERDRDSGQSSMSS----------LSP-PPHNF---ICG 1518
            ||....|:    ..|.:|.|    :..|....|.|...||          :|| ..|.|   |..
 Worm    24 EEGEPQTIHPNKEQLSRRHAIIPDQPSENQETSSQGCCSSDNVIIVPHVQISPNESHLFNRAISS 88

  Fly  1519 GAGKSSGSD----VERQDSGVGSET--SKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAP 1577
            |.|..:.|:    ::.|.:.:.|:.  ::.|..:...:|.:|....:..|
 Worm    89 GGGLLADSNKITSIDLQRATIASQAFYAEASEPQKNRSPWILKRLYEWSG--------------- 138

  Fly  1578 LVCRKCGKKRVERKEII-------------------------------------TEIVETEEKY- 1604
                     |.:|:|||                                     |.|..::.||
 Worm   139 ---------RAKRREIIKHVQAALETSKDHEIEDDELEKLLPVSFEEMFMGDETTTIPSSKHKYL 194

  Fly  1605 --------------GRDLQIILEEFCHPM---LVAGLLTQEQLSAIFLNTEDLLENNQTLAERMR 1652
                          .|.|.::.:.:..|:   .|.|.|...:...:|.|.:.|...::|..:...
 Worm   195 QAVWELFHTELVFLYRQLFVLRDVYKEPLKRCQVEGCLLLVEPDLLFGNLDQLCRISRTFCQSFL 259

  Fly  1653 DALD-MSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLANLEKEKELLRIFLKVS 1716
            ..|. :..|..|...|.|::...|......:.|:::||:........|.::.:::|....|.::.
 Worm   260 SLLSTVDKENWDCTQLVVDLFERFSKGPSTISAYQAYCINYKATMEYLGSIRQKEERFTEFERIC 324

  Fly  1717 QMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLNHINQEA 1781
            ..:.... |:.|...|:.|:||:|:.|:||..::|        |...::::.|:|..::.:.:..
 Worm   325 LADERCF-RLQLEDLLIAPLQRITRLPILLREIHK--------RSEEEESKGKVEKVIDTMTESL 380

  Fly  1782 KDVPTK-----------------LWRRISSSSPNRRASCEIDMINIKL-RKMAIDVLEWNHDEVR 1828
            :.:...                 :|..||...|.   |...|.:.:.| |:...::|.  |...:
 Worm   381 RSIDDSVQWLHNFERLQQLQTQVVWPNISDLEPK---SYVPDFLRVALSRQFCENLLA--HPRRK 440

  Fly  1829 FAMEGRLLYTQPTDSNWKKARTIKLTPVNALLVTNGKPSANY-----------RAEKAMSEKLNF 1882
            ...||.|                       .||.||:....|           :.:|.
 Worm   441 LIHEGPL-----------------------ELVENGRTVDMYAFLFNDMFVLTKTKKC------- 475

  Fly  1883 PKHTGIREASLLLVK----EKCGRYTLIREPLYLDRCVVCSEADWDD------------------ 1925
                    ||.|.||    .|...|.:.|:|:.||.||.| :||.:|
 Worm   476 --------ASKLKVKGVPIGKSEHYIVQRQPVPLDSCVFC-DADSNDQATPMSLKFAFVIIHLTR 531

  Fly  1926 YFEVQEISSKDTFIFKAEDGVRTKQWYTQLQ 1956
            |::|..|     :..:|.|....:.|..:.|
 Worm   532 YYQVVGI-----YTLQAADKADKELWIEKFQ 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	42/241 (17%)
prhg-1	NP_001122556.1	RhoGEF	196..385	CDD:279015	36/197 (18%)
		PH_PLEKHG7	440..557	CDD:270065	32/160 (20%)
		PH	441..561	CDD:278594	33/161 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910