DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF64C and exc-5

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_001294029.1	Gene:	exc-5 / 177692	WormBaseID:	WBGene00001366	Length:	861	Species:	Caenorhabditis elegans

Alignment Length:	944	Identity:	184/944 - (19%)
Similarity:	312/944 - (33%)	Gaps:	315/944 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1158 LVPHETELLKILRNPVEAVKLNL--------VPHVCGLRAPTRESGKSKKIQEEE----VSGTPV 1210
            |.|..:.|:::...|..|.:|:.        ||.|      ..|.|......|||    |.|..|
Worm    32 LAPKMSSLVQLPSQPSSAFQLDFDAVRNFQNVPPV------DLEGGTLIDATEEEEIDPVDGCTV 90

  Fly  1211 KDPGFIAKLLQDPMLGQVAEGLE-------TETV---------AELIENSLQRLQQARRGIDMSG 1259
            :  .|..::|....:.::.:.:.       |:|:         |.::|.| ||:..     |:.|
Worm    91 R--VFTYRILSADEMEELTKTVRQKIKFDCTQTMRSLKMIGSEANVVEKS-QRISG-----DIKG 147

  Fly  1260 TKDHDDMNRLISASLQRIRLERQPATPGISATKEEDRLSNRGSISSANSFASAHNYELFDFDGGA 1324
            .|..:..|......|.:..|:..|       ..|:|:..:|......|:|.|..:
Worm   148 MKPIEFSNNSKQICLDQHSLQLDP-------NDEQDQQISRVLNQVPNTFMSLLS---------- 195

  Fly  1325 GGNESDCYQSCSSEL-----TASGILEEDSVSPIKDPETELDAATRAKFYQLLVDATLAEIEHST 1384
              .|.|.:.....||     |.|.::...:...|.:|:.  ...||.|          :...:|:
Worm   196 --REKDMFVKLYPELFEKMRTESSLIPSTTTEIITNPDG--STTTRVK----------SSKSYSS 246

  Fly  1385 HMDQTLGTDSEHHYESIRHSGDPIYEEIHEVPPPLPLSAPPLNDAELEKKAARSIFEGASKYDIL 1449
            |..:     .|.:...:                               ||.::|.|....:|
Worm   247 HFSR-----QETYVNGV-------------------------------KKMSKSKFRAFVEY--- 272

  Fly  1450 SYLVDAKERGLAREESFDYGNNPKIIEEEAADTLSDLDKRQAEERERDRDSGQSSMSSLSPPPHN 1514
                          :..|.|...|         |||.|:.:..|.|::.|.     :|||
Worm   273 --------------KGPDGGFQVK---------LSDGDEFELSEDEQEDDD-----TSLS----- 304

  Fly  1515 FICGGAGKSSGSDVERQDSGVGSETSKTSRSK-YQATPTVLHLCEDCDGAVEMQVGDNGILYAPL 1578
                   :|..|::: .:|.:...:.||...| ||..                       .||
Worm   305 -------QSCYSEID-SESDITGPSPKTDLDKRYQKA-----------------------WYA-- 336

  Fly  1579 VCRKCGKKRVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLEN 1643
                           ..|:|::|::|...|:::.:.|.:.::...|:|.::::.:..|...|.:.
Worm   337 ---------------AKELVDSEQRYVDKLKLLGDTFRNRLIKEELITNDKITRLLANVSSLYQF 386

  Fly  1644 NQTLAERMRDALDMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLANLEKEKEL 1708
            :.|      ..|...||...|...|..|..:.......|..:..|......|:.|...|:|:|:.
Worm   387 HNT------HFLPQLLESIRDWHTTKRIANVVRKQAPFLKMYSEYTNNYDRATKLFEELKKKKKF 445

  Fly  1709 LRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYK-VTPSHLE------GRELLKQA 1766
            ..:..::.  :.|....:.|...|:.|||||.:|.|||....| :.||.::      ..||:.||
Worm   446 ADVVKEIE--KQAECEGLPLGHHLICPVQRVMRYQLLLQEYKKHLQPSDVDFDDTTVALELVLQA 508

  Fly  1767 QEKIELHLNHINQEAK---------DVPTKLWRRISSSSPNRR---------------------- 1800
            ..       |.|:..|         :|..:|...||..||.|.
Worm   509 AA-------HANEMMKKLDRFGKVIEVQEQLGNSISLVSPGRELLKSGSVQKISSTTEKTEERFI 566

  Fly  1801 --------ASCEIDMINIKLRKMAIDVLEWNHDEVRFAMEGRLL------YTQPTDSNWKKARTI 1851
                    .:.|..||.:...|:.. |...:|.:|   .||..|      |.:.:|....| |.:
Worm   567 FLFNDLVILASERKMIGVSKYKLRA-VFSASHMQV---CEGDNLEREHSFYLRGSDGTGPK-RCV 626

  Fly  1852 KL-TP--------VNALLVTNGKPSANYRAEKAMSEKLNF--PKHTGIREASLLLVKEK-CGRYT 1904
            :| ||        |:::...         .::|.:..|.|  ...:.|.|.:...::.| |....
Worm   627 ELFTPTQKEKNDWVDSIFSI---------IDEAKAHSLTFTSSSRSSISENNNNSIESKHCADCD 682

  Fly  1905 LIREPLYLDR---CVVCSEADWDDYFEVQEISSK-----DTFIFKAE-DGVRTKQWYTQ------ 1954
            :  |..:|.|   ||.||.......|..:...||     ||.....: ||: .:.:.||
Worm   683 I--EFGFLSRGSKCVKCSRRLCKKCFGRRRNESKKHRICDTCTKNMDLDGI-PRSFSTQSNMRRN 744

  Fly  1955 -LQYHAQGMGAWR----KRRNALANIMINGMLAR 1983
             ||..|:|.|...    :.|.:|..::...|:.|
Worm   745 LLQLPAKGSGVLHSSQIRFRGSLGKLLDRFMVVR 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	44/192 (23%)
exc-5	NP_001294029.1	RhoGEF	336..514	CDD:279015	45/209 (22%)
		PH	545..647	CDD:278594	18/115 (16%)
		PH1_FGD1-4_like	545..643	CDD:275423	18/102 (18%)
		FYVE	676..727	CDD:214499	14/52 (27%)
		PH-like	<773..845	CDD:302622	2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910