Protein Alignment RhoGEF64C and rhgf-2

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: NP_001368191.1
• Gene: rhgf-2 / 173748
• WormBaseID: WBGene00006476
• Length: 1149
• Species: Caenorhabditis elegans
• Alignment Length: 892
• Identity: 178/892 - (19%)
• Similarity: 313/892 - (35%)
• Gaps: 248/892 - (27%)

  Fly  1124 GSATSSTPINTPPVISSTPATPPPTDLPIENANPLVPHETELLKILRNPVEAVKLNLVPHVCGLR 1188
            ||||.||         |.|.|...:: |:..........|.||.....|...|.|:.:
 Worm     5 GSATPST---------SIPCTFTSSE-PLSAMRLCYNGATTLLAATACPAAFVDLDSI------- 52

  Fly  1189 APTRESGKSKKIQEEEVS----------GTPVKD-PGFIAKLLQDPMLGQVAEGLETETVAELIE 1242
               ||...|.:..:.:.|          |:|:.: |.........|.
 Worm    53 ---REEPPSPRPLDRDDSVFFRESCSTIGSPLDELPALPTSSTSSPF------------------ 96

  Fly  1243 NSLQRLQQARRGIDMSGTKDHDDMNRLISASLQRIRLERQPATPGISATKEEDRLSNRGSISSAN 1307
            ..::.:|:.|:    |..:.:...:.||:.  ::.|..|:|:.|.|..|.:|  :|:  |:..|.
 Worm    97 KFMESIQRKRK----SMFRRNQSSSNLINT--EKRRTTRRPSLPSIPPTIDE--MSS--SVGHAR 151

  Fly  1308 S-FASAHNYELFDFDGGAGGNESDCYQSCSSELTASGILEEDSVSPIKDPETELDAATRAKFYQL 1371
            | ..|.||                   ..::|......|:.                   :.:.:
 Worm   152 SRRPSLHN-------------------DWTNEHAQRNALDN-------------------RIHHI 178

  Fly  1372 LVDATLAEIEHSTHMDQTLGTDSEHHYESIRHSGDPIYEEIHEVPPPLPLSAPPLNDAE--LEKK 1434
            .:|.  .:|.:...:.:.|....:...|.||...:.:..|:.|  |.|.:....:||.|  |||.
 Worm   179 DIDP--PQINYFIAVFKDLDDREKDSVEHIRFDCNQLIYEVFE--PFLRIRGLTINDVEFFLEKS 239

  Fly  1435 -------------AARSIF-EGASKYDILSY------LVDAKER--------GLAREESFDYGNN 1471
                         |.:.|| .|.....::.:      :.::.||        .::|:.||   .|
 Worm   240 STPIPENSGARFLAGQRIFVRGRGNMKVVRHTRATHSMDESNERATRKMSAEAVSRKSSF---VN 301

  Fly  1472 PKIIEEEAADTLSDLDKRQAEERERD-----RDSGQSSMSSLSPPPHNFICGGAGKSSGSDVERQ 1531
            .:|:...:.:.........||.|..|     |||.|....|.|..|.:   ||..::......|.
 Worm   302 SRILNRGSRNHPGLNGSDDAECRSNDSSLSVRDSWQYDEPSCSEVPDD---GGTRRARSVTSSRI 363

  Fly  1532 DSGVGSETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPLVCRK-----------CGK 1585
            ....|.||.|..:..::              .:..:..|..:.|......|           ...
 Worm   364 SLFFGKETGKIEKEMFR--------------ILNQKKEDTDLEYPTYKLEKDWREIVHNHESLSD 414

  Fly  1586 KRVERKEIITEIVETEEKYGRDLQII--LEEFCHPMLVAGLLTQEQLSAIFLNTEDL-------- 1640
            |.::::|.|.|||.||.:|.:.|:.:  |..:...:...|.|...:...:|.|...|
 Worm   415 KSIKQQEAIWEIVTTEFRYIKLLRYLSNLSFYLTDLQNCGFLKDIENRLVFFNFVTLFNVNYDSL 479

  Fly  1641 -LENNQTLAERMRDA---LDMS-LEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLA 1700
             |::.:.:..:.|:.   ||:: |:.|..|:  .|..|.:.:|    |...|..::.....|
 Worm   480 WLQSIEPILAKSRETGEPLDVNYLQNGFRDI--ENWSRCYTNF----HLAHSDSLKHIQKKL--- 535

  Fly  1701 NLEKEKELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQ 1765
               ||.|..|.|:..::.:..:.|:..:::| .||:||:|:|.|||..:.|||....| ||::..
 Worm   536 ---KESENFRDFVTWAEAQENLDRQKLIDTF-SVPMQRLTRYNLLLKAVLKVTTDENE-REMISN 595

  Fly  1766 AQEKIELHLNHINQEAKDVPTKLWRRISSSSPNRRASCEIDMINIKLRKMAIDVLEWNHDEVRFA 1830
            ..:..|.....:|:|                          :.|..||.|..||:.        .
 Worm   596 LVDCAESATAQLNKE--------------------------LNNNDLRAMLGDVMR--------T 626

  Fly  1831 MEGRLLYTQPTDSNWKKARTIKLTPVN----ALLVTNGKPSAN---YRAEKAMSEKLNFPK---H 1885
            :||.....|   ...::...:|| |:|    ..|:...||:..   ||.:..|.|.....|   |
 Worm   627 IEGPDYVDQ---DELERLFNLKL-PLNLGDFMPLLHPRKPTHRTLIYRGDLRMQEGKKGSKADVH 687

  Fly  1886 TGIREASLLL---VKEKCGRYTLIREPLYLDRCVVCSEADWDDYFEV 1929
            ..|.....|:   |:.|..|..:::.|:::.:.:....||.:.::.|
 Worm   688 CIIFTDMFLICRKVQGKKDRLKILKPPIHMGKMMFHYFADQNGFYLV 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	50/200 (25%)
rhgf-2	NP_001368191.1	RBD_PLEKHG5	186..262	CDD:340588	17/77 (22%)
		RhoGEF	419..608	CDD:238091	51/202 (25%)
		PH_PLEKHG5_G6	665..765	CDD:270064	15/70 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910