DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF64C and Arhgef1

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_006539628.1	Gene:	Arhgef1 / 16801	MGIID:	1353510	Length:	980	Species:	Mus musculus

Alignment Length:	931	Identity:	189/931 - (20%)
Similarity:	306/931 - (32%)	Gaps:	314/931 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1204 EVSGTPVKDP---GFIAKLLQDPMLGQVAEGLETETVA--ELIENSLQRLQQARRGIDMSGTKDH 1263
            ||:|.....|   |.::.:     :|...|..|.|..|  |...:..|.|:|.:|      ...|
Mouse     3 EVAGGAAPGPPRSGLVSII-----IGAEDEDFENELEANSEDQNSQFQSLEQVKR------RPAH 56

  Fly  1264 DDMNRLISASLQRIRLERQPATPGISATKEEDRLSNRGSISSANSFASAHNYELFDFDGGAGGNE 1328
                  :.|.||.:.|:.:|..  :......|.||:.|...:..:|.
Mouse    57 ------LMALLQHVALQFEPGP--LLCCLHADMLSSLGPKEAKKAFL------------------ 95

  Fly  1329 SDCYQSCSSELTASGILEEDSVSPIKDPET---ELDAA--------TRAKFYQLLVDATLAEIEH 1382
             |.|.|         .||:.:|..:..|.:   |||..        .:.:|.|.:|.:..|.:..
Mouse    96 -DFYHS---------FLEKTAVLRVPVPPSVAFELDRTRPDLISEDVQRRFIQEVVQSQQAAVSR 150

  Fly  1383 S------------THMDQTL-------GTDSEHHYESIRHSGDPIYEEI----HEVPPPLPLSAP 1424
            .            |..:|.|       |.|..::....||..:.:...:    |.:......||.
Mouse   151 QLEDFRSKRLMGMTPWEQELSLLEPWIGKDRGNYEARERHVAERLLSHLEETQHTISTDEEKSAA 215

  Fly  1425 PLNDAEL------------EKKAARSIFE------------GASKYDILSYL------------- 1452
            .:....|            :||:.|:.|.            ..:|..:.|.|
Mouse   216 VVTAISLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPPKTKKGLSSILDPARWNRGEPSAP 280

  Fly  1453 --------VDAKERGLA-REESFDYGNNPKIIEEEAAD----TLSDLDKRQAEERERDRDS---- 1500
                    .||::.|.| |:......:..:.:.....|    :|..|.....:.||...|:
Mouse   281 DCRHLKVEADAEKPGPADRKGGLGMSSRDRTVGTPGQDNPGVSLHPLSTDSVDSREPGVDTPQEP 345

  Fly  1501 ------GQSSMSSLSPP---------------------------------PHNFICGGAGKSSGS 1526
                  |.:|:..|:||                                 |.....|..|:..|.
Mouse   346 GDTPPQGPTSLEPLAPPESTEDNGETERRWKRLSGRLGRSESLRVSDRRRPSRGSLGAKGRGGGR 410

  Fly  1527 DVERQDSGVGSETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNG------------------I 1573
            .....|...||.|:....:: :|||               :.||:|                  .
Mouse   411 SRSDVDMDPGSATAVLGPTR-RATP---------------EPGDDGEPGRSGLELEPEEPPGWRE 459

  Fly  1574 LYAPLVCRKCGKKRVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTE 1638
            |..|.......|.:|:|:|:|:|::.||..:.|.|:::.:.|..||...|....::|..||.:.:
Mouse   460 LVPPDTLLSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFYQPMADGGFFPLDELQNIFPSLD 524

  Fly  1639 DLLENNQTLAERMRDALDMSLEQGDDDLLTVNIGRIFL--------DFTQMLHAFESYCVRQAGA 1695
            :|:|.:....:|:     |...| :...|...||.:.|        .:.|.:.:  .:|.||
Mouse   525 ELIEVHSLFLDRL-----MKRRQ-ESGYLIEEIGDVLLARFDGAEGSWFQKISS--RFCSRQ--- 578

  Fly  1696 SLLLANLE-KEKELLRIFLKVSQMENAV-LRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLE 1758
            |..|..|: |:::..|....|.:.|:.. .||:.|...:...:||:|||||||..:.:.|....|
Mouse   579 SFALEQLKAKQRKEPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEESTE 643

  Fly  1759 GRELLKQAQEKIELHLNHINQEAKDVPTKL-----WRRI------SSSSPNRRASCEIDMINIKL 1812
             |..::.|.|.....|:|:||..:|:...|     .||:      .||.|.......:|:...||
Mouse   644 -RGKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLTHLRQSSDPMLSEFKNLDITKKKL 707

  Fly  1813 -----------RKMAIDVLEWNHDEVRFAMEGRLLYTQPTDSNW---KKARTIKLTPVNALLVTN 1863
                       :..||:|.....|::       ||..|..|...   ..:||:..||       :
Mouse   708 VHEGPLTWRVTKDKAIEVHVLLLDDL-------LLLLQRQDERLLLKSHSRTLTPTP-------D 758

  Fly  1864 GK---------PSANYRAEKAMSEKLNFPKHTGIREASLL---------------LVKEKCGRYT 1904
            ||         .||..| |.|...|..:...|..:||.:.               |:.|..|...
Mouse   759 GKTMLRPVLRLTSAMTR-EVATDHKAFYVIFTWDQEAQIYELVAQTSSERKNWCNLITETAGSLK 822

  Fly  1905 L---------------IREPL 1910
            :               |||||
Mouse   823 VPAPASRLKPRPSPSSIREPL 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	52/195 (27%)
Arhgef1	XP_006539628.1	RGS_p115RhoGEF	50..242	CDD:188709	40/233 (17%)
		PHA03247	<277..462	CDD:223021	31/200 (16%)
		RhoGEF	479..663	CDD:214619	52/195 (27%)
		PH_p115RhoGEF	697..821	CDD:275429	29/138 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810