DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF64C and Itsn1

DIOPT Version :9

Sequence 1:NP_001261425.1 Gene:RhoGEF64C / 38578 FlyBaseID:FBgn0035574 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_006522994.1 Gene:Itsn1 / 16443 MGIID:1338069 Length:1743 Species:Mus musculus


Alignment Length:1810 Identity:342/1810 - (18%)
Similarity:572/1810 - (31%) Gaps:615/1810 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   495 SILKRPTTLELPGVGMSPLPLPPVNNSGLVTPAGKSQFYI-------------PTPTGT-----A 541
            ||..:...|:|.|..: |..||||.....|..:....|.|             |.|.|:     .
Mouse   103 SIAMKLIKLKLQGYQL-PSTLPPVMKQQPVAISSAPAFGIGGIASMPPLTAVAPVPMGSIPVVGM 166

  Fly   542 ATPTSSSTPMATSTPTPNAS---ITATTAAAGAAIT-----------PGSRKKVQFMVEDKI-IA 591
            :.|..||.|.|...|..|.:   |....|.|..|.|           |||:...:....... :|
Mouse   167 SPPLVSSVPPAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVA 231

  Fly   592 TTATAATTDDSDASAVATKTNYEYYNRKRNAATATAAAATAASAAAASPPTAATSTDQQEATLF- 655
            :...||......:|.:..:..:..:::..:.......|.|.  ...:|.|.|      |.|::: 
Mouse   232 SAPPAAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTI--LMQSSLPQA------QLASIWN 288

  Fly   656 AADIDDEHNFTT--------------SGEAAPPFIKPDSL--HYEDVLPGPQIFDSSESSAKLSL 704
            .:|||.:...|.              ||:..||.:.|:.:  .:..|..|..:...|.||....|
Mouse   289 LSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGMSVISSSSVDQRL 353

  Fly   705 PADGSPHVTTSPVSVLPT-----GTSNGVGGAGLGPGPAGVSGEEAPATAAATAAATQKTTAANR 764
            |.:.|......|...||.     ...|...|:        |..|:............|:..|...
Mouse   354 PEEPSSEDEQQPEKKLPVTFEDKKRENFERGS--------VELEKRRQALLEQQRKEQERLAQLE 410

  Fly   765 DYDDDDEHNDKDESHDNKPNDL-----------AEREQDREGDKEQGRAGELGISRQ-------- 810
            ..:.:.:..::.|....:..:|           .:||::|..:.|:..|.:..:.||        
Mouse   411 RAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERN 475

  Fly   811 -----------------------------------EKKDAGGK------PAASQKRAAQTTQSRN 834
                                               :|....||      ..|:|::..::|....
Mouse   476 RRQELLNQRNKEQEGTVVLKARRKTLEFELEALNDKKHQLEGKLQDIRCRLATQRQEIESTNKSR 540

  Fly   835 PIRRA---HSERHLSTAPLAAHGHASSACAAGRNCHSIPMTPPASGPQNVILN-----------F 885
            .:|.|   |.::.|.          .|....||..           |:..||:           .
Mouse   541 ELRIAEITHLQQQLQ----------ESQQMLGRLI-----------PEKQILSDQLKQVQQNSLH 584

  Fly   886 KDTMALRIKSNRSDSRDLFQRRPTEPPPPPPPKGAGK---------GLEPLPHEINKSPLSPQRT 941
            :|:: |.:| ...::::|.:::..|.......:...|         .|:.|....:|..|..||:
Mouse   585 RDSL-LTLK-RALEAKELARQQLREQLDEVERETRSKLQEIDVFNNQLKELREIHSKQQLQKQRS 647

  Fly   942 VVRVAPFKPQQQQVGGSGDGFTHEVHRLKISHSEEDADLGVELR-------------RRPNLFLS 993
             :..|..|.::|           |...|::...:|||...|:.|             .||.    
Mouse   648 -LEAARLKQKEQ-----------ERKSLELEKQKEDAQRRVQERDKQWLEHVQQEEQPRPR---- 696

  Fly   994 SPGEEDAAPKKTSILISGDDCYSTMNLSANAAQPLYQ--SSVVVNSHSATSVCISVSSAEEQEQE 1056
            .|.|||...::.|:         ....:...|:|..|  .|.:.:.|...:...:.:.....|:.
Mouse   697 KPHEEDRLKREDSV---------RKKEAEERAKPEMQDKQSRLFHPHQEPAKLATQAPWSTTEKG 752

  Fly  1057 LNQLNTLRSQQMGMGIAIIPI--RGASEVNLQ-RSVSCISS--TSSSSTSSSSSSSGRGRTLIRL 1116
            ...::...|.::....|:.|.  |...|:.:| ..:..:..  ...|.|.......|        
Mouse   753 PLTISAQESVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGG-------- 809

  Fly  1117 DYDRERKGSATSSTPIN-----------TP--PVISSTPATPP-------PTDLPIENANP-LVP 1160
                |.||. |...|.|           ||  ||...|.|..|       |..||:.::.| ..|
Mouse   810 ----ELKGK-TGWFPANYAEKIPENEVPTPAKPVTDLTSAPAPKLALRETPAPLPVTSSEPSTTP 869

  Fly  1161 H-----------------ETELLKILRNPVEAVKLNL-VPHVCGLR-----APTRESGKSKKI-- 1200
            :                 ||:     .....|.:.:| ||....||     .|...:|.|...  
Mouse   870 NNWADFSSTWPSSSNEKPETD-----NWDTWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVL 929

  Fly  1201 -QEEEVSGTPV---------KD-------PGFIAKLLQDPM--LGQV--AEGLETETVAELIENS 1244
             |.|:|.|...         ||       ...|..|.|..|  .|:|  .:|...::..:||...
Mouse   930 GQGEKVEGLQAQALYPWRAKKDNHLNFNKSDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGP 994

  Fly  1245 LQRLQQARRGIDMSGTKDHDDMNRLISASLQRIRLERQPATPG--------ISATKEEDRLSNRG 1301
            :::    ...||...|:....:.|:.|.:       .:||.||        ..::::.|....:|
Mouse   995 VRK----STSIDTGPTESPASLKRVASPA-------AKPAIPGEEFIAMYTYESSEQGDLTFQQG 1048

  Fly  1302 SI----------------SSANSFASAHNY-ELFDFDG-------GAGGNESDCYQSCSSELTAS 1342
            .:                ..:..|.|  || .|.|.:|       |:.|.:.:..|..:| ..|:
Mouse  1049 DVIVVTKKDGDWWTGTVGDKSGVFPS--NYVRLKDSEGSGTAGKTGSLGKKPEIAQVIAS-YAAT 1110

  Fly  1343 GILEEDSVSP-------IKDP----ETELDAATR--------AKFYQLLVDATLAEIEHSTHMDQ 1388
            | .|:.:::|       .|:|    |.||.|..:        |.:.:||...|            
Mouse  1111 G-PEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGT------------ 1162

  Fly  1389 TLGTDSEHHYESIRHSGDPIYEEIHEVPPPLPLSAPPLNDAELEKKAAR-SIFEGASKYDILSYL 1452
                                    .::.|           .||.|.|.: ::.:....||..:..
Mouse  1163 ------------------------SKITP-----------TELPKTAVQPAVCQVIGMYDYTAQN 1192

  Fly  1453 VDAKERGLAREESFDYGNNPKIIEEEAADTLSDLDKRQAEERERDRDSGQSSMSSLSPPPHNFIC 1517
            .|        |.:|..|....::.:|      |.|..:.|.      |||..:.     |.|:: 
Mouse  1193 DD--------ELAFSKGQIINVLNKE------DPDWWKGEV------SGQVGLF-----PSNYV- 1231

  Fly  1518 GGAGKSSGSDVERQDSGVGSETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPLVCRK 1582
                                 ...|.....|...:.|||.:               :..|     
Mouse  1232 ---------------------KLTTDMDPSQQWCSDLHLLD---------------MLTP----- 1255

  Fly  1583 CGKKRVERKE--IITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQ 1645
                 .|||.  .|.|::.|||.|..|||::.|.|..|:..:.|||:::::.||:|.::|:..|.
Mouse  1256 -----TERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLTESELLTEKEVAMIFVNWKELIMCNI 1315

  Fly  1646 TLAERMRDALDMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLANLEKEKELLR 1710
            .|.:.:|....||.|:    :....||.|.......:..:..:|..|...:.|:.....|....:
Mouse  1316 KLLKALRVRKKMSGEK----MPVKMIGDILSAQLPHMQPYIRFCSCQLNGAALIQQKTDEAPDFK 1376

  Fly  1711 IFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLN 1775
            .|:|...|:.. .:.|.|:||::.|:||||:|||::..:.:.||.:......||.|.||.|...:
Mouse  1377 EFVKRLAMDPR-CKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCS 1440

  Fly  1776 HINQEAKDVPTKLWRRISSSSPNRRASCEIDMINIKLRKMAIDVLEWNHDEVRFAMEG---RLLY 1837
            .:|:..::                              |...|.|||....|:  .||   :|::
Mouse  1441 QVNEGVRE------------------------------KENSDRLEWIQAHVQ--CEGLSEQLVF 1473

  Fly  1838 TQPTD----------SNWKKARTIK-----LTPVNALLVTNGKPSANYRAEKAMSEKLNFPKHTG 1887
            ...|:          ....||::.|     |.....||....||..:...:|..|.|.|.     
Mouse  1474 NSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNL----- 1533

  Fly  1888 IREASLLLVKEKCGRYTLIREPLYLDRCVVCSEAD-----------------------------W 1923
                          :|.:.:.|::|:..:|....|                             |
Mouse  1534 --------------QYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAW 1584

  Fly  1924 DDYFEVQEISSKDTFIFKAEDGVRTKQWYTQLQYHAQGMGAWRKRRNALANIMIN 1978
                 ||:|.:......:.|...|.|.:..:.| .|.|:|          .:|:|
Mouse  1585 -----VQKIKAASELYIETEKKKREKAYLVRSQ-RATGIG----------RLMVN 1623

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF64CNP_001261425.1 RhoGEF 1593..1779 CDD:279015 55/185 (30%)
Itsn1XP_006522994.1 EH 39..132 CDD:197477 10/29 (34%)
PLN02983 <155..226 CDD:215533 18/70 (26%)
EH 238..333 CDD:197477 17/102 (17%)
PTZ00121 <355..739 CDD:173412 69/439 (16%)
SH3 766..825 CDD:388381 14/71 (20%)
INTAP 825..939 CDD:374674 27/118 (23%)
SH3_Intersectin1_2 939..990 CDD:212922 9/50 (18%)
SH3_Intersectin1_3 1028..1079 CDD:212924 6/52 (12%)
SH3_Intersectin1_4 1096..1160 CDD:212926 15/65 (23%)
SH3_Intersectin1_5 1180..1233 CDD:212928 15/99 (15%)
RhoGEF 1260..1443 CDD:238091 55/187 (29%)
PH_13 1462..1615 CDD:374702 30/179 (17%)
C2_Intersectin 1604..1738 CDD:176021 7/31 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 82 1.000 Domainoid score I8425
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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