DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF64C and Fgd1

DIOPT Version :9

Sequence 1:NP_001261425.1 Gene:RhoGEF64C / 38578 FlyBaseID:FBgn0035574 Length:1984 Species:Drosophila melanogaster
Sequence 2:NP_032027.2 Gene:Fgd1 / 14163 MGIID:104566 Length:960 Species:Mus musculus


Alignment Length:614 Identity:128/614 - (20%)
Similarity:214/614 - (34%) Gaps:154/614 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1407 PIYEEIHEV-PPPLPLSAPPLNDAELEKKAARSIF---EGASKYDILSYLVDAKERGLAREESFD 1467
            |.|.::..| |||.|:..||......:.:.|:.:.   |.::....:|.|::..||......|..
Mouse   165 PSYLQMPRVLPPPEPIPPPPSRPLPADPRVAKGLVPRAEASTSSAAVSSLIEKFEREPVIVASDR 229

  Fly  1468 YGNNPKIIEEEAA--------DTLSDLDKRQAE-------------ERERDRDSGQSSMSSLS-- 1509
            ....|..:..|.|        .|.|.|.:.:|.             |:..:||||..|:||.|  
Mouse   230 PAPGPCPVPPEPAMLPQPPPQPTGSQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNS 294

  Fly  1510 ----------PPPHNFICGGAGKSSGSDV----------ERQDSGVGSETSKTSRSKYQATPTVL 1554
                      ||.|: :|.|....:...|          :..||.:..|..:....|.:..|.  
Mouse   295 EETCFVSDDGPPIHS-LCPGPPALASMPVALADPHRPGSQEVDSDLEEEEEEEEEEKEREIPV-- 356

  Fly  1555 HLCEDCDGAVEMQVGDNGILYAPLVCRKCGKKRVERK--EIITEIVETEEKYGRDLQIILEEFCH 1617
                                 .|:..::..:..|::|  .|..|:::||:.|...|.::.:.|| 
Mouse   357 ---------------------PPMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFC- 399

  Fly  1618 PMLVAGLLTQ---------EQLSAIFLNTEDLLENNQTLAERMRDALDMSLEQGDDDLLTVNIGR 1673
                |.||.:         :.:..||.|...:...:|   :.:...|:..:|:.|   ....||.
Mouse   400 ----ARLLEEARNRSSFPADVVHGIFSNICSIYCFHQ---QFLLPELEKRMEEWD---RYPRIGD 454

  Fly  1674 IFLDFTQMLHAFESYCVRQAGASLLLANLEKEKEL-LRIFLKVSQMENAVLRRMNLNSFLMVPVQ 1737
            |.......|..:..| |:....::.|.|...|:.. .::.:...|.|.| ...:.|...::.|||
Mouse   455 ILQKLAPFLKMYGEY-VKNFDRAVELVNTWTERSTQFKVIIHEVQKEEA-CGNLTLQHHMLEPVQ 517

  Fly  1738 RVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIEL---HLNHINQEAKDVP-----TKLWRRISS 1794
            |:.:|.||| :.|.:...|  |....|.||:.:||   ...|.|...:.:.     .|::..:..
Mouse   518 RIPRYELLL-KDYLLKLPH--GSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGG 579

  Fly  1795 S----SPNRRASCEIDMINIKLRKMAIDVLEWNHDEVRFAMEGRLLYTQPTDSNWKKARTI-KLT 1854
            .    ||.:....|..::.:..:...      ..|........||||..|      :.|.: :..
Mouse   580 EEDIVSPTKELIKEGHILKLSAKNGT------TQDRYLILFNDRLLYCVP------RLRLLGQKF 632

  Fly  1855 PVNALLVTNGKPSANYRAEKAMSEKLNFPKHTGIREASLLLVKEKCGRYTLIREPLYLDRCVVCS 1919
            .|.|.:..:|       .|...|..||.|:        ..||..|       :..|.|.......
Mouse   633 SVRARIDVDG-------MELKESSNLNMPR--------TFLVSGK-------QRSLELQARTEEE 675

  Fly  1920 EADWDDYFEVQEISSKDTFIFKAEDGVRT 1948
            :.||     ||.|:|.   :.|.|..:.|
Mouse   676 KKDW-----VQAINST---LLKHEQTLET 696

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF64CNP_001261425.1 RhoGEF 1593..1779 CDD:279015 48/198 (24%)
Fgd1NP_032027.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..210 11/44 (25%)
SH3-binding. /evidence=ECO:0000255 171..187 7/15 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..355 27/129 (21%)
RhoGEF 375..558 CDD:238091 48/198 (24%)
PH1_FGD1 590..697 CDD:275392 30/149 (20%)
PH 590..687 CDD:278594 27/138 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 701..725
FYVE_FGD1_2_4 724..788 CDD:277280
PH2_FGD1-4 814..919 CDD:270056
PH 822..920 CDD:278594
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 922..960
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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