DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF64C and ARHGEF19

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_694945.2	Gene:	ARHGEF19 / 128272	HGNCID:	26604	Length:	802	Species:	Homo sapiens

Alignment Length:	932	Identity:	172/932 - (18%)
Similarity:	297/932 - (31%)	Gaps:	332/932 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1142 PATPPPTDLPIENANPLVPHETELLKILRNPVEAVKLNLVPHVCGLRAPTRESGKSKKI----QE 1202
            ||..||:.:.:: ..|:.|.|      ||.|.....|.....:.||..|....|...:|    ..
Human    38 PALKPPSPVCLD-LFPVAPEE------LRAPGSRWSLGTPAPLQGLLWPLSPGGSDTEITSGGMR 95

  Fly  1203 EEVSGTPVKDPGFIAKLLQDPMLGQVAEGLETETVAELIENSLQRLQQARRGIDMSGTKDHDDMN 1267
            ...:|:....||.....|:.|.                   |.:..|..||....|..|
Human    96 PSRAGSWPHCPGAQPPALEGPW-------------------SPRHTQPQRRASHGSEKK------ 135

  Fly  1268 RLISASLQRIRLERQPATPGISATKEEDRLSNRGSISSANSFASAHNYELFDFDGGAGGNESDCY 1332
                ::.:::|:.::...||                                           |.
Human   136 ----SAWRKMRVYQREEVPG-------------------------------------------CP 153

  Fly  1333 QSCSSELTASGILEEDSVSPIKDPETELDAATRA--------KFYQLLVDATLAEIEHSTHMDQT 1389
            ::.:..|....:::|.::| .::|..||..:||.        :|       :.:|:....|....
Human   154 EAHAVFLEPGQVVQEQALS-TEEPRVELSGSTRVSLEGPERRRF-------SASELMTRLHSSLR 210

  Fly  1390 LGTDSE--------------------HHYESIRHSGDPIYEEIHEVPPPLP-------LSAPPLN 1427
            ||.:|.                    ....|:..|||       .|..|.|       .|.|.|:
Human   211 LGRNSAARALISGSGTGAAREGKASGMEARSVEMSGD-------RVSRPAPGDSREGDWSEPRLD 268

  Fly  1428 DAELEKKAARSIFEGASKYDILSYLVDAKERGLAREESFDYGNNPKIIEEEAADTLSDLD-KRQA 1491
            ..|.....:||..|......:|:                      .::.:|.:|..|..: :||.
Human   269 TQEEPPLGSRSTNERRQSRFLLN----------------------SVLYQEYSDVASARELRRQQ 311

  Fly  1492 EERERDRDSGQSSMSSLSPPPHNFICGGAGKSSGSDVERQDSGVGSETSKTSRSKYQATPTVLHL 1556
            .|.|...|..:.:.....||..|.       |..|....|.|..||     :.|.:|..|
Human   312 REEEGPGDEAEGAEEGPGPPRANL-------SPSSSFRAQRSARGS-----TFSLWQDIP----- 359

  Fly  1557 CEDCDGAVEMQVGDNGILYAPLVCRKCGKKRVERKEIITEIVETEEKYGRDLQIILEEFCHPMLV 1621
                      .|..:|:| |.|..|.|     :.:|...|::.:|..|...|.:.:..|.....:
Human   360 ----------DVRGSGVL-ATLSLRDC-----KLQEAKFELITSEASYIHSLSVAVGHFLGSAEL 408

  Fly  1622 AGLLTQEQLSAIFLNTEDLLENNQTLAERMRDALDMSLEQGDDDLLTVNIGRIFLDFTQML-HAF 1685
            :..|..:....:|....::    ::.:||....|:..||.   |:|..::..:.||..... ..:
Human   409 SECLGAQDKQWLFSKLPEV----KSTSERFLQDLEQRLEA---DVLRFSVCDVVLDHCPAFRRVY 466

  Fly  1686 ESYCVRQAGAS-----LLLANLEKEKELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLL 1745
            ..|...||...     |||.|......|.|:      .|:.|.:|:.|.|||::|.||:|:..:|
Human   467 LPYVTNQAYQERTYQRLLLENPRFPGILARL------EESPVCQRLPLTSFLILPFQRITRLKML 525

  Fly  1746 LARLYKVTPSHLEG-----------RELLKQAQEKIE--------LHLN-HINQEAK-------- 1782
            :..:.|.|....|.           :||:::....::        :||: .|:.|.|
Human   526 VENILKRTAQGSEDEDMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQA 590

  Fly  1783 -----------------DVPTKLWRRISSSSP-----------NRR--------------ASCEI 1805
                             ..|.||  ::||.:.           :||              |..::
Human   591 RWLVRHGELVELAPLPAAPPAKL--KLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAELQV 653

  Fly  1806 DMINIKLRKM-----AIDVLEWNHDEVRFAMEGRLLYTQPTDSNWKKARTIKLTPVNALLVTNGK 1865
            ..:::||:.:     .:.:|...|.:.:|.:..|   |:.....|          ::||.
Human   654 RDLSLKLQGIPGHVFLLQLLHGQHMKHQFLLRAR---TESEKQRW----------ISALC----- 700

  Fly  1866 PSANYRAEKAMSEKLNFPKHTGIREASLLLVKEKCGRYTLIREPLYLDRCVVCSEADW--DDYFE 1928
            ||:....::.:||..:.|:...:|....|...|           |.|::..:.|...|  |.:.|
Human   701 PSSPQEDKEVISEGEDCPQVQCVRTYKALHPDE-----------LTLEKTDILSVRTWTSDGWLE 754

  Fly  1929 ----------------VQEISS 1934
                            |:||||
Human   755 GVRLADGEKGWVPQAYVEEISS 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	45/211 (21%)
ARHGEF19	NP_694945.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Herpes_ICP4_C	10..>353	CDD:332854	77/442 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..138		13/82 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..190		6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..283		13/67 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..342		10/42 (24%)
		RhoGEF	382..558	CDD:306973	42/188 (22%)
		PH_ephexin	580..706	CDD:269929	22/145 (15%)
		SH3_ARHGEF5_19	719..773	CDD:212873	10/64 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810