DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF64C and RhoGEF64C

DIOPT Version :10

Sequence 1:NP_729032.1 Gene:RhoGEF64C / 38578 FlyBaseID:FBgn0035574 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_061506670.1 Gene:RhoGEF64C / 1277109 VectorBaseID:AGAMI1_005448 Length:1960 Species:Anopheles gambiae


Alignment Length:2256 Identity:899/2256 - (39%)
Similarity:1169/2256 - (51%) Gaps:612/2256 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DKSKKSWSQRLKTLGSGDSVDKNASLAAVSGMQAMQQLQLHMQQQHQQLQQHQQQLQQQQQQQQQ 67
            |||||:|.||||...:....:...|....:|..:.....|                         
Mosquito    43 DKSKKTWGQRLKLSKASPIAEDKQSPGPTNGTASSNGSAL------------------------- 82

  Fly    68 QQHMAHHGHPQMLTAYQLPPVPAAEFL---PSALS---------------RSMKYAEPWIYGTVR 114
                    .|....:|.    |:.::.   |::||               .:|||||.|:|||||
Mosquito    83 --------IPFGARSYD----PSLDYSGNGPASLSSVGHSNSSHTNVHQLATMKYAETWVYGTVR 135

  Fly   115 GIP----ARPSYGYHPHAAAIFAATEGVPGTTALAVVICSCAEYLNGTKRDVKKASVCKKCKGSR 175
            |:|    ..|.:.:|||..|::...   |....:||:||.|.|||.||||::|||||||||||||
Mosquito   136 GMPPPLAMSPHHPHHPHLPAMYCPP---PPPPEVAVLICCCPEYLTGTKREIKKASVCKKCKGSR 197

  Fly   176 LPLATIGGTGGTVRLPAVSGSSSSRRP----MAATMRVVSA-TKKSRPSIL-DPQKDPYDLMRRT 234
            ||||.|   |||:||  .||::....|    .|.|:::.|. .|||||:|| :...||||.|||:
Mosquito   198 LPLAPI---GGTMRL--TSGATYLAPPPIRTSAGTVKLASTYGKKSRPTILGNGNPDPYDFMRRS 257

  Fly   235 RLLSPE------PSSKEADSKSRSRSETVANQP-RGRT-------RTRAPPPPAP-IQKSPAVAV 284
            ||..|.      |.|.::..|.:.|....:..| |||:       |:.|...|:| :.|:.:...
Mosquito   258 RLTQPAESGAGGPKSVKSSLKEKLRGRAKSTSPSRGRSGSTAGGKRSSAARSPSPSLSKNGSRVG 322

  Fly   285 PTAVPDPTDCWLME-DNESLLQSSGLASRANSRRSILRCHVNPYDLIS------SENGKLHSN-- 340
            ...:....|||:.| |.::.|...|..|.|.:|:|||||.||||||||      |..|....|  
Mosquito   323 GRKLESFQDCWVGEPDRDTDLLDDGPTSTAQNRKSILRCDVNPYDLISLSGIGGSSGGGTSGNNM 387

  Fly   341 ---LRKPNDHFDVADAQLNDDELGERKSKGTSKFYSGNVAAIAGQRISLGDKSGDSSDPGDSYER 402
               .....|.||: .:|..::.|....:...:...:.::|||.||||.|.|.||.|......|:.
Mosquito   388 LNEFAPDGDEFDL-HSQKYENILDTLYANRYNPNPANSIAAINGQRIKLFDDSGTSVSGAPVYDD 451

  Fly   403 I-------IMVSGGESTASN--------GPRRPPRNKKA--------DEPAEMP-------AAAG 437
            :       :.|...|:.|::        .|.||||:|:.        |:...:|       |.||
Mosquito   452 VDEFVYDPVEVPVEEAAATDELSSPSAGTPERPPRSKQRQLEATKENDDSRSLPSTAPLGTAEAG 516

  Fly   438 AAGAAGAAATS-----------PPAAAVTAATAVKPKAVTLAKVEKIEKDNES---AYTVLTVTP 488
            :.|...:|..|           ||::.||                 :|||..:   .|..:.:..
Mosquito   517 SPGVTQSAIKSILKRPSSMPAGPPSSMVT-----------------VEKDTGAGGPGYDTIRLNH 564

  Fly   489 TSPAIKSILKRPTTLELPGVG---------------MSPLPLPPVNNSGLVTPAGKSQFYIPTPT 538
            |      :::|...|...|.|               :|...|....|||       ||||:||| 
Mosquito   565 T------LVQRLAKLTTNGNGSASEEGASTFGKHGTISARHLTDKRNSG-------SQFYLPTP- 615

  Fly   539 GTAATPTSSSTPMATSTPTPNASITATTAAAGAAITPGSRKKVQFMVEDKIIATTATAATTDDSD 603
                      .|:..||..|:|:.:.|          |.||||.|:||::||.            
Mosquito   616 ----------FPVIASTSEPDATQSTT----------GGRKKVHFLVENEIIH------------ 648

  Fly   604 ASAVATKTNYEYYNRKRNAATATAAAATAASAAAASPPTAATSTDQQEATLFAADIDDEHNFTTS 668
                                                                    ||:..|.  
Mosquito   649 --------------------------------------------------------DDDRLFA-- 655

  Fly   669 GEAAPPFIKPDSLHYEDVLPGPQIFDSSESSAKLSLPADGSPHVTTSPVSVLPTGTSNGVGGAGL 733
                       .:.:.:|:||                          .|:.:|..|:||      
Mosquito   656 -----------QMLFTEVVPG--------------------------EVTPVPVKTTNG------ 677

  Fly   734 GPGPAGVSGEEAPATAAATAAATQKTTAANRDYDDDDEHNDKDESHDNKPNDLAEREQDREGDKE 798
                                 ||::..||             :||..::.:.||..:|....:..
Mosquito   678 ---------------------ATERGAAA-------------EESIGSRKDTLASSKQVETEELA 708

  Fly   799 Q---------GRAGELGISRQEKKDAGGKPAA----SQKRAAQTTQSRNPIRRAHSERHLSTAPL 850
            :         ..|..|.....|::.   ||:|    .|:||       .|:||:.|:|...||..
Mosquito   709 KVILLPAATITNAPMLANGTNEERT---KPSAVATVFQRRA-------GPVRRSFSDRSSPTAKT 763

  Fly   851 AAH-GHASSACAAGRNCHSIPMTPPASGPQNVILNFKDTMALRIKSNRSDSRDLF---------- 904
            ..: ||                  ||:|.......|.||||||::..|:|||..|          
Mosquito   764 NGYGGH------------------PANGTTARDDQFNDTMALRVRPLRTDSRTAFDDETASLTTS 810

  Fly   905 -----------------------QRRPTEPPPPPPPK---------------------------- 918
                                   :.||..|||||||.                            
Mosquito   811 SSSSSESSIGSISSLLLAVGQGGKARPKLPPPPPPPPPTTQLPTSPNGKAPASATPSPPGSNVYE 875

  Fly   919 ----GAGKGLEPLPHEINKSPLSPQRTVVRV---------------APFKPQQ-----QQVGGSG 959
                |...|:.....:.:.|..:..||||:|               :|..|..     ..:..||
Mosquito   876 DFCFGLMAGVRRSSSDRSSSTSTSSRTVVQVLASSSSFSSSSSSSSSPSSPSSCGSSPSPIASSG 940

  Fly   960 DGFTHEVHRLKISHSEEDADLGVELRRRPNLFLSSPGEEDAAPKKTSILISGDDCYSTMNLSANA 1024
            .     :|||:|.|..|.                   ||:...|||||||:|||||||:|:...:
Mosquito   941 G-----IHRLEIRHDPEP-------------------EEEHYQKKTSILITGDDCYSTVNVDGAS 981

  Fly  1025 AQPLYQSSVVVNSHS-------------ATSVCISVSSAEEQEQELNQLNTLRSQQMGMGIAIIP 1076
            ..|:||||||||..|             :.::.|||||         ..:||.|:.....:|...
Mosquito   982 DTPIYQSSVVVNDGSMVASPTNEIRQTASNTITISVSS---------PTSTLESRGSKGRMATGK 1037

  Fly  1077 IRGASE------VNLQR-SVSCISS-TSSSSTSSSSSSSGRGRTLIRLDYDRERKGSATSSTPIN 1133
            :.|..:      |.:.| .|:.:|: ||......||.:...|||||.||:.:..: |..|||...
Mosquito  1038 LAGDEQHANGTVVTMGREEVTTVSTGTSVVPIGGSSVTGSNGRTLINLDFGQPEQ-SVESSTAAQ 1101

  Fly  1134 TPPVISS--TPATPPPTDLPIENANPLV----PHETELLKILRNPVEAVKLNLVPHVCGLR---A 1189
            |....|.  ||..|.|:|......:|.|    .|:.:..:.:   |:...::|.|....||   .
Mosquito  1102 TDTKTSEDVTPIAPVPSDSNDSKDSPKVREDAAHDQQQQQTV---VKQTSVDLTPTPVVLRRSLK 1163

  Fly  1190 PTRESGKSKKIQEEEVSGTPVKDPGFIAKLLQDPMLGQVAEGLETETVAELIENSLQRLQQARRG 1254
            ||.|...:....:.:|...     .||||||:||.|.|::|||:.|.:|:|||:||.||:::|.|
Mosquito  1164 PTTEPTTTVNSLQAKVCRN-----SFIAKLLEDPSLSQLSEGLDYELIAKLIESSLLRLKESRNG 1223

  Fly  1255 IDMSGTKDHDDMNRLISASLQRIRLERQ----PATPGISATKEEDRLSNRGSISSANSFASAHNY 1315
            :|||||||.||::::|..||.:|:.||.    |:.|. |.:.:::..|.|.|:||.||:.||..|
Mosquito  1224 LDMSGTKDEDDVSKMIEQSLLKIQEERSKLTAPSNPA-SQSPQQNSGSKRSSVSSGNSYGSAAAY 1287

  Fly  1316 ELFDFDGGAGGNESDCYQSCSSELTASGILEEDSVSPIKDPETELDAATRAKFYQLLVDATLAEI 1380
            ||.:||  ..|..|||||||||:||    :::|:.|            :|:||||:||||||:|:
Mosquito  1288 ELMEFD--QLGELSDCYQSCSSDLT----VDDDAHS------------SRSKFYQMLVDATLSEL 1334

  Fly  1381 EHSTHMDQTLGTDSEHHYESIRHSGDPIYEEIHEVPPPLPLSAPPLNDAELEK-KAARSIFEGAS 1444
            |.:|..:.   .|.||||||||.:||||||||:::||||||:|||::|.:||| :.|||||||||
Mosquito  1335 EINTANED---DDDEHHYESIRLNGDPIYEEINDIPPPLPLTAPPIDDVDLEKQRNARSIFEGAS 1396

  Fly  1445 KYDILSYLVDAKERGLAREE---SFDYGNNPKII-EEEAADTLSDLDKRQAEERERDRDSGQSSM 1505
            |||||||||||||||:.:|:   .|.:|....|| |||.::.:::|  |..:.:..|..|..|.:
Mosquito  1397 KYDILSYLVDAKERGIVQEDGSYGFQFGGAGDIILEEEESEPITEL--RHHQRQISDISSRLSHL 1459

  Fly  1506 SSLSPPPHN------FICGGAGKSSGSDVERQDSGVGSETSKTSRSKYQ---ATPTV-------- 1553
            |.:|....:      .:..|....:.:::||.||||||||||||||::|   :|.|.        
Mosquito  1460 SGISDSSEDTSLSAGTLSNGRSSKASAEIERNDSGVGSETSKTSRSRWQNPISTTTTSTTTSSLL 1524

  Fly  1554 -----LHLCEDCDGAVEMQVGDNGILYAPLVCRKCGKKRVERKEIITEIVETEEKYGRDLQIILE 1613
                 :||||||||.||.||.::|::|||||||||||||.|||||||||||||||||||||||||
Mosquito  1525 TKITPIHLCEDCDGPVETQVTESGVMYAPLVCRKCGKKRAERKEIITEIVETEEKYGRDLQIILE 1589

  Fly  1614 EFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQTLAERMRDALDMSLEQGDDDLLTVNIGRIFLDF 1678
            ||..||||||||.||||||||||.|:||||||.||||||||||::.||||||||||:||:|||:.
Mosquito  1590 EFYQPMLVAGLLNQEQLSAIFLNVEELLENNQFLAERMRDALDIANEQGDDDLLTVSIGKIFLEA 1654

  Fly  1679 TQMLHAFESYCVRQAGASLLLANLEKEKELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYP 1743
            ..||||||||||||..|||||||||||||||||||:|||||||||||||||||||||||||||||
Mosquito  1655 APMLHAFESYCVRQGAASLLLANLEKEKELLRIFLRVSQMENAVLRRMNLNSFLMVPVQRVTKYP 1719

  Fly  1744 LLLARLYKVTPSHLEGRELLKQAQEKIELHLNHINQEAKDVPTKLWRRISSSSPNRRASCEIDMI 1808
            |||||||||||:||||:|||||:||||||||||:|:||||||||||||||||||.||.|||:|||
Mosquito  1720 LLLARLYKVTPAHLEGKELLKQSQEKIELHLNHMNREAKDVPTKLWRRISSSSPGRRLSCELDMI 1784

  Fly  1809 NIKLRKMAIDVLEWNHDEVRFAMEGRLLYTQPTDSNWKKARTIKLTPVNALLVTNGKPSANYRAE 1873
            ||||||||:|||||||:|||||:|||||:|||.|.||||:||||||.:||||||||||:|:|:|:
Mosquito  1785 NIKLRKMAVDVLEWNHEEVRFAIEGRLLFTQPNDGNWKKSRTIKLTSINALLVTNGKPTASYKAD 1849

  Fly  1874 KAMSEKLNFPKHTGIREASLLLVKEKCGRYTLIREPLYLDRCVVCSEADWDDYFEVQEISSKDTF 1938
            :|:||.|:||:||||||||||||:||.|||||:||||:||||:||||.||:||||||||.||::|
Mosquito  1850 RALSETLSFPRHTGIREASLLLVREKGGRYTLLREPLFLDRCIVCSEHDWEDYFEVQEILSKESF 1914

  Fly  1939 IFKAEDGVRTKQWYTQLQYHAQGMGAWRKRRNALANIMINGMLARS 1984
            |||||||.:|||||.|||||:||||.||||||||||||||||:.|:
Mosquito  1915 IFKAEDGTKTKQWYAQLQYHSQGMGTWRKRRNALANIMINGMMTRT 1960

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF64CNP_729032.1 RhoGEF 1590..1778 CDD:238091 166/187 (89%)
RhoGEF64CXP_061506670.1 None

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