Protein Alignment RhoGEF64C and FGD4

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: NP_001357227.2
• Gene: FGD4 / 121512
• HGNCID: 19125
• Length: 903
• Species: Homo sapiens
• Alignment Length: 796
• Identity: 157/796 - (19%)
• Similarity: 275/796 - (34%)
• Gaps: 224/796 - (28%)

  Fly  1272 ASLQRIRLERQ--PA--TPGISA--TKEEDRLSNRGSISSANSFASAHNYELFDFDGGAGGNES- 1329
            ::.:|:.:.|:  |:  .||:..  ::....|...|:.:......|           ||.|:.:
Human     7 SNFRRVAIRRKSNPSYLPPGVPRPWSRPASHLGRVGTAAFKGQVPS-----------GATGSSTC 60

  Fly  1330 -------DCYQSCSSELTASGILEEDSVS-----PIK----DPETELDAATRAKFYQLLVDATLA 1378
                   .|..|.::.|....:.||::..     |.|    .|:.::.
Human    61 PKIALVPPCSTSSTTTLVGENVSEEEAQGINGNRPAKHSAASPKPQVP----------------- 108

  Fly  1379 EIEHSTHMDQTLGTDSEHHYESIRH----SGDPIYEEIHEVPPPLPLSAPPLNDAELEKKA-ARS 1438
              ....|:.   .:.|.:.:::.||    |..|..|||.      |.||..::..:..|.: ..|
Human   109 --PKPLHLQ---NSPSSNIHQTPRHKALPSAKPRMEEIK------PASASCVSKEKPSKVSDLIS 162

  Fly  1439 IFEGASKYDILSYLVDAKERG-----------------------LAREESFDYGN---------- 1470
            .|||.|.   ||...|.|:..                       |::......||
Human   163 RFEGGSS---LSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQT 224

  Fly  1471 ----------NPKIIEEEAADTLSDLDKRQAEERERDRD--SGQSSMSSLSP--PPHNFICGGAG 1521
                      |....|||.|.|||.....||.|...|..  :|:...::.:|  |..:...|.|.
Human   225 CVANGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGNAS 289

  Fly  1522 KSS------GSDVERQDSGVGSETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPLVC 1580
            .||      |..:..::.|..:||....|...: :|..|   |..|...||
Human   290 DSSYRTPGIGPVLPLEERGAETETKVQERENGE-SPLEL---EQLDQHHEM-------------- 336

  Fly  1581 RKCGKKRVERK--EIITEIVETEEKYGRDLQIILEEFCHPMLV---AGLLTQEQLSAIFLNTEDL 1640
                |:..|:|  :|..|::.||..|...|.::.:.|...:|.   .|....|.::.||.|...:
Human   337 ----KETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSI 397

  Fly  1641 LENNQTLAERMRDALDMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLANLEKE 1705
               |...::.:...|:..:::.:   .|..||.|.......|..:..|......|..|:.|:.:.
Human   398 ---NAFHSKFLLPELEKRMQEWE---TTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTER 456

  Fly  1706 KELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLA-RLYKVTPSHLEGRELLKQAQEK 1769
            ....:..::..|.:. :...:.|...::.||||:.:|.:||. .|.|:.|..|:..: .|::.|.
Human   457 IPQFKSVVEEIQKQK-ICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWND-AKKSLEI 519

  Fly  1770 IELHLNHINQEAKDVPTKLWRRISSSSPNRRASCEIDMINIKLRKMAIDVLEWNHDEVRFAMEGR 1834
            |....:|.|...:                       .|.|:|......::|....|.|
Human   520 ISTAASHSNSAIR-----------------------KMENLKKLLEIYEMLGEEEDIV------- 554

  Fly  1835 LLYTQPTDSNWKKARTIKLTPVNALLVTNGKPSANYRAEKAMSEKLNF--PKHTGIREASLLLVK 1897
                .|::...|:.:.:||...|.        ||..|.....:..|.:  ||.:        ||.
Human   555 ----NPSNELIKEGQILKLAARNT--------SAQERYLFLFNNMLLYCVPKFS--------LVG 599

  Fly  1898 EKCGRYTLIREPLYLDRCVVCSEADWDDYFEVQEISSKD-TFIFKAEDGVRTKQWYTQLQYHAQG 1961
            .|   :| :|..:.:|...:. |...::|....::|.|: |...:|......::|...||   :.
Human   600 SK---FT-VRTRVGIDGMKIV-ETQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQ---ET 656

  Fly  1962 MGAWRKR----RNALA 1973
            :.|:.:|    |||:|
Human   657 IDAFHQRHETFRNAIA 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	41/189 (22%)
FGD4	NP_001357227.2	RhoGEF	344..528	CDD:238091	41/191 (21%)
		PH1_FDG4	560..653	CDD:275434	23/113 (20%)
		FYVE_FGD1_2_4	691..755	CDD:277280
		PH2_FGD1-4	774..876	CDD:270056

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810