DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF64C and NET1

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_001040625.1	Gene:	NET1 / 10276	HGNCID:	14592	Length:	596	Species:	Homo sapiens

Alignment Length:	427	Identity:	99/427 - (23%)
Similarity:	189/427 - (44%)	Gaps:	72/427 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1482 TLSDLDKRQAEERERDRDSGQSSMSSLSPPPHNFICGGAGKSSGSDVE----RQDSGVGSETSKT 1542
            :||.||.::...:.....:..:|:::|..|..|    ||.:..|..::    |     |...|..
Human    78 SLSSLDLKEPSNKRVRPLARVTSLANLISPVRN----GAVRRFGQTIQSFTLR-----GDHRSPA 133

  Fly  1543 SRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPLVCRKCGKKRVERKEIITEIVETEEKYGRD 1607
            |..|:.:..||....:....|:..::.|. .:...|..|:     :.|:|.|.|:...|:....|
Human   134 SAQKFSSRSTVPTPAKRRSSALWSEMLDI-TMKESLTTRE-----IRRQEAIYEMSRGEQDLIED 192

  Fly  1608 LQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQTLAERMRDAL--DMSLEQGDDDLLTVN 1670
            |::..:.:..|||...::::|:|:.||.:.:..:..::.|..|:.:|.  |.::||
Human   193 LKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQ--------- 248

  Fly  1671 IGRIFLDFTQMLHAFESYCVRQAGASLLLANLEKEKELLRIFLKVSQMENAVLRRMNLNSFLMVP 1735
            ||.|.:.:...|:|:..||..|..|..|| :.:|:...::.||: ..:|:...|:::|.|||.:|
Human   249 IGHILVSWLPRLNAYRGYCSNQLAAKALL-DQKKQDPRVQDFLQ-RCLESPFSRKLDLWSFLDIP 311

  Fly  1736 VQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLNHINQEAKDVPTKLWRRISSSSPNRR 1800
            ..|:.||||||..:.|.||......:||:.|...|:..|:.||.:..:
Human   312 RSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGE----------------- 359

  Fly  1801 ASCE-----IDMINIKLRKMAIDVLE--WNHDEVR---------FAMEGRLLYTQPTDSNWKKAR 1849
            :.|:     ::.::.|.|...|:..:  ..|.|:|         |..:..|:.|:|...|.:.:.
Human   360 SECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSY 424

  Fly  1850 TI--KLTPVNALLVT-----NGKPSANYRAEKAMSEK 1879
            .:  :..||..|::.     :.:...::|...:.|||
Human   425 QVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEK 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	55/187 (29%)
NET1	NP_001040625.1	Necessary for nuclear localization. /evidence=ECO:0000250	1..74
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Nuclear localization signal. /evidence=ECO:0000250	12..19
		Nuclear localization signal. /evidence=ECO:0000250	66..72
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..146		6/18 (33%)
		RhoGEF	178..354	CDD:214619	54/186 (29%)
		PH_Net1	368..502	CDD:270044	18/94 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	562..596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.800