Protein Alignment RhoGEF64C and Arhgef18

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: XP_030099069.1
• Gene: Arhgef18 / 102098
• MGIID: 2142567
• Length: 1434
• Species: Mus musculus
• Alignment Length: 1156
• Identity: 229/1156 - (19%)
• Similarity: 390/1156 - (33%)
• Gaps: 371/1156 - (32%)

  Fly   922 KGLEPLPHEINKSPL----SPQRTVVRVAPFKPQ----------QQQVGGSGDGFTHEVHRLKIS 972
            :|.||.|:   ..||    :...|.....|.||:          :|:     |||...     :|
Mouse    30 RGSEPKPY---AQPLDSAAAASTTKGSCGPRKPENPDFFSTVEDEQE-----DGFLRH-----LS 81

  Fly   973 HSEED--ADLGVELRRRPNLFLSSPGEEDAAPKKTSILISGDDCYSTMNLSANAAQPLYQSSVVV 1035
            .|.||  .|:|.                          :.|.:....:.|  .|...|:||.|::
Mouse    82 ESTEDFSLDMGA--------------------------LQGSEYLRDLGL--GAPSDLHQSEVIM 118

  Fly  1036 NSHSATSVCISVSSAEEQEQELNQLNTLRSQQMGMGIAIIPIRGASEVNLQRSVSCISSTSSSST 1100
            :             .|...||..:.::..|.:   |.:.:|.|.:.|    ||.||..|....|.
Mouse   119 D-------------PETHRQEARRESSHTSCE---GASALPQRRSWE----RSRSCSGSCRRLSL 163

  Fly  1101 SSSSSSSGR--GRTLIRLDYDRERKGS---ATSSTPINTPPVISSTPATPPPTDLPIENANPLVP 1160
            .:|:...|.  .|||..|..:....|.   .....|::         .||.|:.
Mouse   164 DASTVDKGACLPRTLASLALNLSGNGQKIWTQGCLPVS---------GTPAPSS----------- 208

  Fly  1161 HETELLKILRNPVEAVKLNLVPHVCGLRAPTRESGKSKKIQEEEVSGTPVKDPGFIAKLLQDPML 1225
                  |...:|.:.::...||..|       |....:...:.:|..:||:.       |:.|:|
Mouse   209 ------KECSSPEKRLRSKSVPVSC-------EISCMELASDSDVCTSPVQG-------LEPPVL 253

  Fly  1226 GQVAEGLETETVAE----LIENSLQRLQQARRGIDMSGTKDHDDMNRLISASLQRIRLERQPATP 1286
                |.||.:.|..    :::..||.|:|                   ...:.||.|:...|
Mouse   254 ----ECLEKDHVEPEHVLIVQQVLQELRQ-------------------YHGARQRARMSTSP--- 292

  Fly  1287 GISATKEEDRLSNRGSISSANSFASAH-NYELFDF-----DGGA----GGNESDCYQSCSSELTA 1341
                                   ..|| |...|:|     ||..    .|..:...:|.||..:.
Mouse   293 -----------------------GGAHSNLTWFEFLSESEDGACKIEKPGKSTRVKRSLSSLRSR 334

  Fly  1342 SGILEEDSVSP--IKDPETELDAATR-AKFYQLLVDATLAEIEHSTHMDQTLGTDSEHHYESIRH 1403
            ....:|...||  :||...:|..... ...:||:                 .||.|       .|
Mouse   335 VTRQKEKGKSPAHLKDKTQDLPGKRECVNGHQLM-----------------RGTFS-------GH 375

  Fly  1404 SGDPIYEEIHEVPPPLPLSAPPLNDAELEKKAARSIFEGASKYDILSYLVDAKERGLAREESFDY 1468
            |..|:..|            |.||.|.|::....::....|.        .|..|.:....|...
Mouse   376 SSCPLCGE------------PLLNSASLKEHPRTTLLSDGSS--------PAPSRNVGMTISQKG 420

  Fly  1469 GNNPKIIEEEAADTLSDLDKRQAEERERDRDSGQSSMSSLSPPPHNFICGGAGKSSG---SDVER 1530
            |..|                                    :|.|     .|:|...|   .|::.
Mouse   421 GLQP------------------------------------TPSP-----AGSGVRLGPIAGDMDE 444

  Fly  1531 QDS----------GVGSETSKTSRSKYQATPTVLHL-CEDCDGAVEMQVGDNGILYAPLVCRKCG 1584
            .||          ...|.||..:.|.:...|.:..| ||....|.|.:.....:.......:|..
Mouse   445 ADSVFLKLKQTADDSLSLTSSNAESVFIEDPYIASLRCEIESDAHEFEAESWSLSVDLAYAKKQK 509

  Fly  1585 KKRVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQTLAE 1649
            |:.|:|::::.|:::||..:.|.|:|:|:.:...:......:.:.:|.:|...:|||:.:.....
Mouse   510 KEVVKRQDVLYELMQTEAHHVRTLKIMLKVYSRALQEELQFSGQAVSRLFPCADDLLDMHSHFLA 574

  Fly  1650 RMRDALDMSLEQGDD-DLLTVNIGRIFL-DFT-----QMLHAFESYCVRQAGA----SLLLANLE 1703
            |:::.....||:|.| :.:...||.:.: .|:     :|...:..:|.....|    .|||...:
Mouse   575 RLKERRQEFLEEGSDRNYVIQKIGDVLVQQFSGETGERMKEKYAVFCSGHNDAVGQYKLLLQQSK 639

  Fly  1704 KEKELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQE 1768
            |.:.|::   |:...  :::||:.:...:::..||:||||:|:.|:.:.|.:..|..:.|.||..
Mouse   640 KFQNLIK---KIGNF--SIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYKDLSQALS 699

  Fly  1769 KIELHLNHI---------NQEAKDVPTKLWRRISSSSPNRRASCEIDMINIKLRKMAID-VLEWN 1823
            .|:..::.:         :|..|::..|..::.|....|.....:.||  ::.|::.:: .|.|.
Mouse   700 LIKDIISQVDAKVSEYEKDQRLKEIAAKTDQKSSGKLKNGLTFRKEDM--LQQRQLHLEGALCWK 762

  Fly  1824 ------HDEVRFAMEGRLLYTQPTDSNWKKARTIKLTPVNALLVTNGKPSANYRAEKAM---SEK 1879
                  .|.:...:...||..|..|..:..|......||.:|.....:..||  .||||   |..
Mouse   763 STSGRLKDVLAVLLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVAN--EEKAMFLISAS 825

  Fly  1880 LNFPKHTGIREASLLLVKEKCGRYTLIREP-----LYLDRCV-VCSEADWDDYFEVQE------- 1931
            :..|              |....||..:|.     .::.|.| .|.:.:.|.:.|.:|
Mouse   826 MQGP--------------EMYEMYTSSKEDRNIWMAHIRRAVESCPDEEEDVFSEAEEKKIAEAR 876

  Fly  1932 ----------ISSKDTFIFKAEDGVRTKQWYTQ------LQYHAQGMGAWR 1966
                      :|.||..|  |:..:..:|.|.:      |:..||..|.:|
Mouse   877 TMKLQEFQERLSLKDQLI--AQSLLEKQQIYLEMAQLSGLEESAQNRGLFR 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	45/205 (22%)
Arhgef18	XP_030099069.1	RhoGEF	515..709	CDD:238091	46/198 (23%)
		PH_ARHGEF18	750..868	CDD:275437	29/133 (22%)
		DUF5401	<1080..>1197	CDD:375164
		PRK13729	1153..>1305	CDD:184281

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810