DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF64C and arhgef11

DIOPT Version :9

Sequence 1:NP_001261425.1 Gene:RhoGEF64C / 38578 FlyBaseID:FBgn0035574 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_017952119.2 Gene:arhgef11 / 100489979 XenbaseID:XB-GENE-992398 Length:1607 Species:Xenopus tropicalis


Alignment Length:1325 Identity:266/1325 - (20%)
Similarity:438/1325 - (33%) Gaps:465/1325 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   911 PPPPPPP------------------------------KGAGKGLEPLPHEINKSPLSPQRTVVRV 945
            |||||||                              |.....|:.|....||||.|..:..:..
 Frog   168 PPPPPPPLPQMHHITGPKPLQDPDFQKHATEILWNMLKQEEADLQNLCDVYNKSPNSSLQEQIER 232

  Fly   946 APFKPQQ------QQVGGSGD---------GFTHEVHRLKISHSEEDADLGV-----------EL 984
            |..:..|      |::.|:||         ...::|...::|...:|.|.|:           |.
 Frog   233 ARKRVHQLQHKIRQEIPGTGDLLRSYSDCSSLGYKVKEGRLSVDSQDGDSGLDSGTERISSLSEY 297

  Fly   985 RRRPNLFLSSPGEEDAAPKKTSILI----------------SGDDCYSTMNLSANAAQPLYQSSV 1033
            ....|..||..|.:.:   .||.:|                .|.|. :.:..|...:.|:     
 Frog   298 SMNRNSVLSDLGMDSS---HTSPIIPTKLFHHHYHHHHHRRQGSDT-AFIATSEQVSDPM----- 353

  Fly  1034 VVNSHSATSVCISVS------SAEEQEQELNQLNTLRSQQMGMGIAIIPIRGASEVNLQRSVSCI 1092
                 .:|.:|....      ..|:.:.....|..|:::...||:.:..|...::.|......|.
 Frog   354 -----KSTIICPEEDYDHGYYMTEQLDGLFQDLERLKTRPAHMGVFLRYIFSQADPNPLLFYLCA 413

  Fly  1093 SSTSSSSTSSSSSSSGRGRTLIRLDYDRERKGSATSSTPINTPPVISSTPATP---PPTDLPIEN 1154
            .:...                                        :|.|.|.|   ...::.::.
 Frog   414 EACQH----------------------------------------LSPTDAFPLRKEVWNIFLDK 438

  Fly  1155 ANPL---VPHETELLKILRNPVEAVKLNLVPHVCGLRAPTRESGKSKKIQEE--EVSGTPVKDPG 1214
            :.||   :|.:      |.|.:|:...|                 |:.|:::  |..|.      
 Frog   439 SAPLRIKIPEQ------LLNEIESRLRN-----------------SEDIRDKFSEAQGA------ 474

  Fly  1215 FIAKLLQDPMLGQVAEGLETETVAELIENSLQRLQQARRGIDMSGTKDHDDMNRLISASLQRIRL 1279
                     ||.::.|.::.              .:.:|.:.:......:|   |:...:...| 
 Frog   475 ---------MLPEIQEQIQD--------------YRTKRTMGLGSLYGEND---LLDLEIDPHR- 512

  Fly  1280 ERQPATPGISATKEEDRLSN-RGSISSANSFASAHNYELFDFDGGAGGNESDCYQSCSSELTASG 1343
            |||.|...|:  :.||.||. ...|||..:|| .:.|..:     ||.:..|...:.:||.:.| 
 Frog   513 ERQVAAKQIA--QLEDILSKYEKEISSPMAFA-LNMYVKY-----AGIHTQDIRPASTSEKSQS- 568

  Fly  1344 ILEEDSVSPIKDPETELDAATRAKFYQLLVDATLAEIEHSTHMDQTLGTDSEHHYESIRHSGDPI 1408
                     |.|.|..|      .|:.....::.|:.|..:..|:               ..:||
 Frog   569 ---------IPDREKWL------PFFPKNKKSSNAKKEDKSAEDK---------------KRNPI 603

  Fly  1409 YEEIHEVPPPLPLSAP------PLNDAELEKKAARSI---FEGASKYDILSY------------- 1451
            .:.|::     |.|..      ||:..|::....|:|   ||...:||:..:             
 Frog   604 LKYINK-----PKSTSQSTFHVPLSPGEVKPGNVRNIIQHFENNQQYDVPEHNLQRLSTGSFPED 663

  Fly  1452 LVDAK----ERGLAREESFDYGNNPKIIEEEAADTL----SDLDKRQAEERERDRDSGQSSMSSL 1508
            |:|:.    |..|.|.||..  ...::.:....|.:    ||:|...|.|..|...|..||.|||
 Frog   664 LLDSDGTRLEVKLGRSESLK--GREELKKSRKVDNVPRSRSDVDMDAAAEATRLHQSASSSASSL 726

  Fly  1509 S--------PPPHNFIC---------GGAGKSSGSDVERQDSGVGSETSKTSRSKYQATPTVLHL 1556
            |        ||....:|         |..|:...|:::..|.|                    ||
 Frog   727 SARSLDNPTPPYTPKLCRRSIESPNLGFTGELLLSNLQEDDLG--------------------HL 771

  Fly  1557 CEDCDGAVEMQ-----VGDNGILYAPLVCRKCGKKRVERKEIITEIVETEEKYGRDLQIILEEFC 1616
             .|.|...:.|     ||.:..|:.      ..|:|. |:|:|.|:..||..:.|.|:::...|.
 Frog   772 -SDLDPEPDAQNWQHTVGRDVALHL------LPKERA-RQEVIHELFVTEASHLRVLRVLDLIFY 828

  Fly  1617 HPMLVAGLLTQEQLSAIFLNTEDLLENNQTLAE---RMRDALDMSLEQGDDDLLTVNIGRIFLDF 1678
            ..|....|||.::|..:|.|..:|:|.:.:|||   |:|:...:..|.||..||..: |....:.
 Frog   829 QRMRKENLLTPDELWLVFPNLPELIEIHNSLAESMKRLREEGPVIKEIGDLMLLRFD-GAAGEEV 892

  Fly  1679 TQMLHAFESYCVRQAGASLLLANLEKEKEL-LRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKY 1742
            ......|.||.:    ::|.|...:|.||. ..:|::.:: .|...||:.|...::..:||:|||
 Frog   893 RMEAAKFCSYQI----SALELIKAKKRKETRFSLFMQEAE-SNPQCRRLQLKDLIVSEMQRLTKY 952

  Fly  1743 PLLLARLYKVTPSHLEGRELLKQAQEKIELHLNHINQEAKDVP-----TKLWRRISSS---SPNR 1799
            ||||..:.|.|.|..:..|.|.:.:::....|..:|:..|...     .:..:|:.:|   ..|.
 Frog   953 PLLLENVLKHTESGTQEHEKLYRCRDRCRDILKFVNESVKQAENEHRLAEYQKRLDASHLERSNN 1017

  Fly  1800 RASCEIDMINIKLRKMAID-VLEWNHDEVR--------FAMEGRLLYTQ--------------PT 1841
            ..:.|...:::..|:|..: .|.|   .||        ..:|..|:..|              .|
 Frog  1018 PLAAEFKNLDLTTRRMIHEGPLTW---RVRDKTIDLHVLLLEDLLVLLQKQDEKLVLKCHSKTTT 1079

  Fly  1842 DSNWKKARTIKLTPV---------NALLV-------------------------------TNGKP 1866
            |:....:..|||..|         .||.:                               |||..
 Frog  1080 DTKQTFSPVIKLNSVLVRSVATDKKALFIICTSDLGPQIYELVALTSSEKNTWMDLLEEATNGAM 1144

  Fly  1867 SANYRAEKAMSEKLNFPKHTGIREASLLLVK-----------------------EKCGRY----- 1903
            .....|.|..|:.:|.|     ..||::|.:                       |..|.:     
 Frog  1145 RNPPGATKRKSQDINRP-----TSASMVLQRAHMPKLTAEGVLRHNSEDPQSGDEGAGEFLGQKP 1204

  Fly  1904 -TLIREPLYLDRCVVCSEADWDDYFE---VQEISSKDTFIFKAEDGVRTKQWYTQLQYH----AQ 1960
             .::.||   :|     |.|.||...   :..|.||:.   .|..|.|.......:.||    .:
 Frog  1205 DVVLEEP---ER-----EDDEDDEARTPTLLPIPSKEE---DAGGGTRGLDSSNHIPYHWPEVTE 1258

  Fly  1961 GMG------AWRKRRNALANIMING 1979
            |:.      ....||..|.|::.:|
 Frog  1259 GLAESALDDVHNLRRLILKNMLHHG 1283

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF64CNP_001261425.1 RhoGEF 1593..1779 CDD:279015 55/189 (29%)
arhgef11XP_017952119.2 PDZ_signaling 63..137 CDD:238492
RGS 357..501 CDD:413378 28/235 (12%)
RhoGEF 805..989 CDD:214619 55/189 (29%)
PH_PRG 1006..1143 CDD:275426 23/139 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.