DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF64C and Plekhg6

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_002729474.2	Gene:	Plekhg6 / 100362241	RGDID:	2318544	Length:	783	Species:	Rattus norvegicus

Alignment Length:	488	Identity:	107/488 - (21%)
Similarity:	181/488 - (37%)	Gaps:	97/488 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1519 GAGKSSGSDVERQDS--------GVGS-------ETSKTSRSKYQATPTVLHLC----------E 1558
            |:|::.|...:..|.        ||||       |.||....:.:     ||..          |
  Rat    62 GSGQTRGLSPQEPDPEKRHGNYFGVGSPYFPKFKEVSKAHELEVR-----LHTFSMFGMPRLPPE 121

  Fly  1559 DCDGAVEMQVGDNGILYAPLVCRKCGKKRV-----------ERKEIITEIVETEEKYGRDLQIIL 1612
            |   ....::|:.|  .:.|...|..|:.|           .::|.:.|::.||..|.|.|:|:.
  Rat   122 D---RRHWEIGEGG--DSALTIEKSWKELVLGHKEMNRELCHQQEALWELLTTELIYLRKLKIMT 181

  Fly  1613 EEFCHPML---VAGLLTQEQLSAIFLNTEDLLENNQTLAERMRDALDMSLEQGDDDLLTVNIGRI 1674
            :.....:|   ..||||:.....:|.|...|:..::...|.:...:..........|..|::...
  Rat   182 DLLAAGLLNLQRVGLLTEVSAETLFGNVPKLIRTHRRFWEEVLQPILEDTRTSGQPLDPVSLQNG 246

  Fly  1675 FLDFTQMLHAFESYCVRQAGASLLLANLEKEKELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRV 1739
            ||.|.|....:..||:|...........:....|.|.|::..: ::....|..|...|:.|.||:
  Rat   247 FLTFGQRFQPYIQYCLRVKQTMAYAREQQDTNPLFRTFVQWCE-KHKRSGRQTLGDLLIKPHQRI 310

  Fly  1740 TKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLNHINQEAKDVPTKLWRRISSSSPNRRASCE 1804
            |||||||..:.|.:|.. ..:..|......:|..|.|||...                 ||...:
  Rat   311 TKYPLLLQAVLKRSPEP-RAQLALDNMIVAVESFLQHINGLV-----------------RRGEEQ 357

  Fly  1805 IDMINIKLRKMAIDVLEWNHDEVRFAMEGRLLYTQPTDSNWKKARTIKL-TPVNALLVTNGKP-- 1866
            ..::.:..|....:|||.:.:||              :.:.::..|:.| ||:..:...|.:.
  Rat   358 ESLMAVAQRIGPYEVLEPSSEEV--------------EKHLRQFSTLDLMTPIEGVAPENTRQLL 408

  Fly  1867 -SANYRAEKAMSEKLNFPKHTGIREASLLLVK--EKCGRYTLIREPLYLDRCVVCSEADWDDYF- 1927
             ....|.::....|::.  :..:....||:.|  .|..:..:||.||.|::.|.....|...:.
  Rat   409 LEGPVRMKEGREGKMDV--YLFLFSDVLLVTKPQRKVDKAKVIRPPLMLEKLVCRPLRDPHSFLL 471

  Fly  1928 ----EVQEISSKDTFIFKAEDGVRTKQWYTQLQ 1956
                |.|.:||..| :..:....|| ||..:.|
  Rat   472 IHLTEFQCVSSALT-VHCSSSTERT-QWLQKTQ 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	48/188 (26%)
Plekhg6	XP_002729474.2	RhoGEF	162..348	CDD:395496	47/187 (25%)
		PH_PLEKHG5_G6	405..503	CDD:270064	23/102 (23%)
		fibronec_FbpA	<566..761	CDD:411474
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810