Protein Alignment CG12493 and ADAR

DIOPT Version :10

• Sequence 1: NP_647927.3
• Gene: CG12493 / 38575
• FlyBaseID: FBgn0035571
• Length: 296
• Species: Drosophila melanogaster
• Sequence 2: NP_001351974.1
• Gene: ADAR / 103
• HGNCID: 225
• Length: 1235
• Species: Homo sapiens
• Alignment Length: 310
• Identity: 64/310 - (20%)
• Similarity: 104/310 - (33%)
• Gaps: 73/310 - (23%)

  Fly    11 IVNVSDQEDAGMSDDLKETAMDCNMP------DGESSLVITDGDSMSKIPDDAAMATSDPKK--- 66
            ::.:.::::|.......:..:..|.|      |.|:....||     .||||.....:.|.:
Human   425 VIKLENRQEARPEPARLKPPVHYNGPSKAGYVDFENGQWATD-----DIPDDLNSIRAAPGEFRA 484

  Fly    67 -------------KKKKVKKLKRSQKAKDRLVRPLPKAVTSKDALMVLKELKGVIIDNMQIKQD- 117
                         :....|||...|     |..|:       ..|:...:......:...|:|.
Human   485 IMEMPSFYSHGLPRCSPYKKLTECQ-----LKNPI-------SGLLEYAQFASQTCEFNMIEQSG 537

  Fly   118 --HEGKNVANIVVNSKKY-DAEGSSENSAGNAACEKALREILTTKMKALLAEPENSSGGDEDNIL 179
              ||.:....:|:|.::: .||..|:..|...|..||        |..||.|.:....|..
Human   538 PPHEPRFKFQVVINGREFPPAEAGSKKVAKQDAAMKA--------MTILLEEAKAKDSGKS---- 590

  Fly   180 EKMTSYAVYKLAEKWNSDAIDVAALYNDVKNKKTSSSVGQLP--KLWKNMHPCMVLMQMRPQTTF 242
            |:.:.|:..|.:||        .|.........||...|:.|  .|.:.||      ::.....|
Human   591 EESSHYSTEKESEK--------TAESQTPTPSATSFFSGKSPVTTLLECMH------KLGNSCEF 641

  Fly   243 KFLGSSG-ENRKVFSMGVSVDNCEF-KADGPTKKDARRKVAALVCNKLFG 290
            :.|...| .:...|...|:|....| ....|:||.|::..|......|.|
Human   642 RLLSKEGPAHEPKFQYCVAVGAQTFPSVSAPSKKVAKQMAAEEAMKALHG 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12493	NP_647927.3	DSRM_SF	95..155	CDD:444671	14/63 (22%)
		DSRM_SF	227..284	CDD:444671	14/58 (24%)
ADAR	NP_001351974.1	z-alpha	144..210	CDD:280459
		z-alpha	304..368	CDD:280459
		DSRM_DRADA_rpt1	511..581	CDD:380742	18/84 (21%)
		DSRM_DRADA_rpt2	622..692	CDD:380743	18/76 (24%)
		DSRM_DRADA_rpt3	734..804	CDD:380744
		ADEAMc	848..1231	CDD:214718