DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18418 and SLC25A14

DIOPT Version :9

Sequence 1:	NP_647924.2	Gene:	CG18418 / 38572	FlyBaseID:	FBgn0035568	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_001269126.1	Gene:	SLC25A14 / 9016	HGNCID:	10984	Length:	353	Species:	Homo sapiens

Alignment Length:	334	Identity:	101/334 - (30%)
Similarity:	167/334 - (50%)	Gaps:	53/334 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EKKTVPTH-------MKFVMGGTSGMLATCIVQPLDLLKTRMQISG-TLGTR----EYKNSFEVL 60
            :|.|..:|       ..||.||.:.::|.....|:||.|||:|:.| ::..|    :|:..|..|
Human    24 QKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHAL 88

  Fly    61 SKVLKNEGILSLYNGLSAGLLRQATYTSAKMGVYQMELDWYRKNFGNYPSMVASMTMGIVAGAFG 125
            .::.|.||:|:||:|::..|||||:|.:.|:|:||.....:.:...: .:::.:|..|:|:|...
Human    89 FRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLED-ETLLINMICGVVSGVIS 152

  Fly   126 AMCGNPAEVALIRMMSDNRLMPEDRRNYKNVGDAFVRIVKDEGVVALWR--------GC------ 176
            :...||.:|..|||.:...|.....     :| :|:.|.:.||...|||        ||
Human   153 STIANPTDVLKIRMQAQGSLFQGSM-----IG-SFIDIYQQEGTRGLWRCLCSKAVTGCVLWLMP 211

  Fly   177 -----------------LPTVGRAMVVNMVQLASYSLMKNQ--LHGYLSEGIPLHLTAALVSGLL 222
                             :||..||.:|..|:|..|.:.|..  |.|.:.:.|..|..::...||.
Human   212 VIPALWEANAGGSLEGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLA 276

  Fly   223 TSVTSMPLDMAKTRIQQMKVIDGKPE-YSGTIDVLKKVLKNEGAFAVWKGFTPYLMRMGPHTIFS 286
            .::.|.|:|:.:||:...:.|.|..: |.||:|.:.|:.|:||.||::|||.|..:|:||..|..
Human   277 GALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIF 341

  Fly   287 FVFLEQMNK 295
            |:..||:.:
Human   342 FITYEQLKR 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18418	NP_647924.2	Mito_carr	10..108	CDD:278578	36/109 (33%)
		PTZ00169	18..296	CDD:240302	98/317 (31%)
		Mito_carr	109..205	CDD:278578	32/128 (25%)
		Mito_carr	208..300	CDD:278578	32/89 (36%)
SLC25A14	NP_001269126.1	Mito_carr	37..133	CDD:278578	34/95 (36%)
		PTZ00169	41..351	CDD:240302	98/317 (31%)
		Mito_carr	134..254	CDD:278578	30/126 (24%)
		Mito_carr	262..351	CDD:278578	32/89 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0759
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54059
OrthoDB	1	1.010	-	-		D892773at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830