Protein Alignment HDAC1 and HOS1

DIOPT Version :10

• Sequence 1: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_015393.1
• Gene: HOS1 / 856181
• SGDID: S000006272
• Length: 470
• Species: Saccharomyces cerevisiae
• Alignment Length: 371
• Identity: 116/371 - (31%)
• Similarity: 173/371 - (46%)
• Gaps: 86/371 - (23%)

  Fly    27 PMKPH-RIRMTHNLLLNYGLYRKM-EIYRPHKATADEMTKFHSDEYVRFLRSIR----------- 78
            |...| :.::|::|:..|.|.:.. |:.....|..|::.:|||..|:.:|.:.|
Yeast    20 PCNNHQKSQLTYSLINAYDLLQHFDEVLTFPYARKDDLLEFHSKSYIDYLINGRFNKMMAQDVNN 84

  Fly    79 -------------PDNMSE---YN--KQMQRF--------------------------------- 92
                         .||.:|   ||  :.:|||
Yeast    85 PMVESKWSELSELADNWNEKIDYNPSQDLQRFTTRENLYNYYLNHSQALENNMDCINNSEVPTND 149

  Fly    93 ---------------NVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWGGGLHHAKK 142
                           |:..|||:|..|..:||:..|.::.....|:.....|.|||.||.|||.|
Yeast   150 KPTDTYILNSETKQYNLEGDCPIFSYLPMYCQVITGATLNLLDHLSPTERLIGINWDGGRHHAFK 214

  Fly   143 SEASGFCYVNDIVLGILELLKYH-QRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGE-YFPG 205
            ..||||||:||:||.|..|.|.. .::.|:|.|:|||||||:||..:.::.|:|.|.|.. :|||
Yeast   215 QRASGFCYINDVVLLIQRLRKAKLNKITYVDFDLHHGDGVEKAFQYSKQIQTISVHLYEPGFFPG 279

  Fly   206 TGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSLTGDRLG 270
            ||.|.|....|.   .|||||:.|.||:..|.|...|::.::|..:|.|::::||.|.|.|||..
Yeast   280 TGSLSDSRKDKN---VVNIPLKHGCDDNYLELIASKIVNPLIERHEPEALIIECGGDGLLGDRFN 341

  Fly   271 CFNLTVKGHGK-CVEFVKKY-NLPFLMVGGGGYTIRNVSRCWTYET 314
            .:.||::|..: .:..:|.| .....::|||||....:||.:||.|
Yeast   342 EWQLTIRGLSRIIINIMKSYPRAHIFLLGGGGYNDLLMSRFYTYLT 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:450134	116/371 (31%)
HOS1	NP_015393.1	HDAC_Hos1	5..390	CDD:212543	116/371 (31%)