Protein Alignment HDAC1 and HOS3

DIOPT Version :9

• Sequence 1: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_015209.1
• Gene: HOS3 / 855987
• SGDID: S000006037
• Length: 697
• Species: Saccharomyces cerevisiae
• Alignment Length: 672
• Identity: 117/672 - (17%)
• Similarity: 204/672 - (30%)
• Gaps: 248/672 - (36%)

  Fly    46 YRKMEIYRPHKATADEM------TKFHSDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGL 104
            |||..:.||.:..|..|      |.:.|...::.....:...|:.:..::.    |...|.  .|
Yeast    64 YRKTIVERPERLLASSMGISAAITMYPSLFTLKSSHQRKGSLMAPHVLKVH----GSSWPA--EL 122

  Fly   105 YEFCQLSAGGSVAAAVKLNKQASEICINWGGG--------------------------------- 136
            .|.||:       |..||.|...|:...|..|
Yeast   123 IELCQM-------ADAKLLKGEIEVPDTWNSGDIYLSSKTIKALQGTIGAIETGVDSIFKGPSAE 180

  Fly   137 -------------LHHAKKSEASGFCYVNDIVLGILELLKYHQ--RVLYIDIDVHHGDGVEE--- 183
                         .||......||||.:|:..:.|......:.  .|:.:|.|:|||||.::
Yeast   181 HISNRAFVAIRPPGHHCHYGTPSGFCLLNNAHVAIEYAYDTYNVTHVVVLDFDLHHGDGTQDICW 245

  Fly   184 ---AFYTTDRVMTVSFHKYGE---YFPGTG-----DLRDIGAGKGKYYAV--------------- 222
               .|...:.....|:..:|:   .||..|     |:.......|  :|.
Yeast   246 KRAGFKPEEEPEDSSYDDFGKKFAEFPKVGYFSMHDINSFPTESG--FATKENIKNASTCIMNSH 308

  Fly   223 -----NIPLRDGMDDD----AYESIFVPIISKVMETFQPA-------------AVVLQCGAD--- 262
                 ||.|.....::    .|.:.:..:.:|..|.|:.|             .||:..|.|
Yeast   309 DLNIWNIHLSKWTTEEEFNVLYRTKYRTLFAKADEFFRSAKLEMNQQGRPFKGLVVISAGFDASE 373

  Fly   263 -------------------SLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNV-- 306
                               :.|.|.|....:..  |||.:..::           |||:.:.:
Yeast   374 FEQTSMQRHSVNVPTSFYTTFTKDALKLAQMHC--HGKVLSLME-----------GGYSDKAICS 425

  Fly   307 ----------SRCWTYETSVALAVEIANEL---------PY-----NDYFEYFG----------- 336
                      ::.|..|..   :.::..|:         ||     .|....:.
Yeast   426 GVFAHLIGLQNQDWVKEWG---SEQVVKEIVRGCKPAWKPYKTKRAKDVIRIWAEEVIRLGRAMI 487

  Fly   337 PDF-------KLHISPSNMTNQNTSE--YLEKIKNRLFENLRMLPHAPGVQIQAIPEDAIND--- 389
            |:|       .::.:|||...:.|.|  ....|..|:..:.|.         .|.||..:::
Yeast   488 PEFDDIIFKDAVNSAPSNSLLKATVEPASTSTIAQRIIRSHRS---------NASPEKELHENKP 543

  Fly   390 ---ESDDEDKVDKDDRLPQSDKDKRI----VP--ENEYSDSEDEGEGGRRD---NRSYKGQRKRP 442
               |..::.::..|.::.|...:.|.    :|  :.|:| ||||.|....|   |:::....:..
Yeast   544 RSTEKQEQREIRSDTKVKQLSSNNRAAETQIPFLQQEFS-SEDEDEEYVYDEELNKTFNRTVEDI 607

  Fly   443 RLDKDTN-------SNKASSETSSEIKDEKEKGD-----GADGEESTASNTN-------SNNNSN 488
            .:|..:.       ..|...::..|:|::..|..     ..:|.....|||.       .|.|:.
Yeast   608 TIDDISRHLETLEIEKKGDEDSDHELKEKNWKNSHQRRLQGNGMYKIPSNTKPHRIRQPQNANTP 672

  Fly   489 NKSDNDAGATANAGSGSGSGSG 510
            ...|:|....::......:.||
Yeast   673 TYDDSDISMISHVSRKHTTRSG 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	85/498 (17%)
HOS3	NP_015209.1	HDAC_Hos3	47..435	CDD:212522	69/398 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810