DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC1 and HDA1

DIOPT Version :9

Sequence 1:	NP_647918.2	Gene:	HDAC1 / 38565	FlyBaseID:	FBgn0015805	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_014377.1	Gene:	HDA1 / 855710	SGDID:	S000004966	Length:	706	Species:	Saccharomyces cerevisiae

Alignment Length:	360	Identity:	99/360 - (27%)
Similarity:	172/360 - (47%)	Gaps:	51/360 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KKRVCY-----YYDSDIGNYY-YGQGHPMKPHRIRMTHNLLLNYGLYR---------------KM 49
            |..:||     |:.....:|: |...||..|.||...:.:|...||..               |:
Yeast    57 KTGLCYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRIYKILAENGLINDPTLSGVDDLGDLMLKI 121

  Fly    50 EIYRPHKATADEMTKFHSDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGG 114
            .:   ..||::|:.:.|:.|::.|:.|....:..|..|:.::   |:.....:..|...:|..||
Yeast   122 PV---RAATSEEILEVHTKEHLEFIESTEKMSREELLKETEK---GDSVYFNNDSYASARLPCGG 180

  Fly   115 SVAA--AVKLNKQASEICINWGGGLHHAKKSEASGFCYVNDIVLGILELLKYH----QRVLYIDI 173
            ::.|  ||...:..:.:.:....| |||:...|.|||..:::.:....:||.:    :|::.:|.
Yeast   181 AIEACKAVVEGRVKNSLAVVRPPG-HHAEPQAAGGFCLFSNVAVAAKNILKNYPESVRRIMILDW 244

  Fly   174 DVHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGT--GDLRDIGAGKGKYYAVNI--PLRDGMDD 232
            |:|||:|.:::||..|:|:.||.|::  |:|:|||  |.....|.|||:.:..||  |: .|:.|
Yeast   245 DIHHGNGTQKSFYQDDQVLYVSLHRFEMGKYYPGTIQGQYDQTGEGKGEGFNCNITWPV-GGVGD 308

  Fly   233 DAYESIFVPIISKVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVK---KYNLPFL 294
            ..|...|..::..:...|:|..|::..|.|:..||.:|..::|...:|.....:|   :.||  .
Yeast   309 AEYMWAFEQVVMPMGREFKPDLVIISSGFDAADGDTIGQCHVTPSCYGHMTHMLKSLARGNL--C 371

  Fly   295 MVGGGGYTIRNVSRCWTYETSVA--LAVEIANELP 327
            :|..|||.:..::|.   ..|||  |..|..:|||
Yeast   372 VVLEGGYNLDAIARS---ALSVAKVLIGEPPDELP 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	99/360 (28%)
HDA1	NP_014377.1	HDAC_Clr3	81..403	CDD:212542	91/334 (27%)
HDA1	NP_014377.1	Arb2	457..698	CDD:401634
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810