Protein Alignment HDAC1 and RPD3

DIOPT Version :9

• Sequence 1: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_014069.1
• Gene: RPD3 / 855386
• SGDID: S000005274
• Length: 433
• Species: Saccharomyces cerevisiae
• Alignment Length: 415
• Identity: 250/415 - (60%)
• Similarity: 321/415 - (77%)
• Gaps: 2/415 - (0%)

  Fly     6 KKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEY 70
            |:||.|:||:|:|||.||.|||||||||||.|:|::|||||:||||||...||..||.:||:|||
Yeast    18 KRRVAYFYDADVGNYAYGAGHPMKPHRIRMAHSLIMNYGLYKKMEIYRAKPATKQEMCQFHTDEY 82

  Fly    71 VRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWGG 135
            :.||..:.|||:..:.::..:||||:||||||||||:|.:|.|||:..|.:||:...::.:|:.|
Yeast    83 IDFLSRVTPDNLEMFKRESVKFNVGDDCPVFDGLYEYCSISGGGSMEGAARLNRGKCDVAVNYAG 147

  Fly   136 GLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYG 200
            |||||||||||||||:|||||||:|||:||.|||||||||||||||||||||||||||.||||||
Yeast   148 GLHHAKKSEASGFCYLNDIVLGIIELLRYHPRVLYIDIDVHHGDGVEEAFYTTDRVMTCSFHKYG 212

  Fly   201 EYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSLT 265
            |:|||||:|||||.|.||.||||:|||||:||..|.|:|.|:|.|:||.:||:|||||||.|||:
Yeast   213 EFFPGTGELRDIGVGAGKNYAVNVPLRDGIDDATYRSVFEPVIKKIMEWYQPSAVVLQCGGDSLS 277

  Fly   266 GDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANELPYND 330
            |||||||||:::||..||.:||.:.:|.::|||||||:|||:|.|.:||.:...|.:..:||||:
Yeast   278 GDRLGCFNLSMEGHANCVNYVKSFGIPMMVVGGGGYTMRNVARTWCFETGLLNNVVLDKDLPYNE 342

  Fly   331 YFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDESDDED 395
            |:||:|||:||.:.||||.|.||.|||:|:...:|.||....:||.||:...|.||.:....:||
Yeast   343 YYEYYGPDYKLSVRPSNMFNVNTPEYLDKVMTNIFANLENTKYAPSVQLNHTPRDAEDLGDVEED 407

  Fly   396 KVDKDDRL--PQSDKDKRIVPENEY 418
            ..:..|..  .|..:|..:..:||:
Yeast   408 SAEAKDTKGGSQYARDLHVEHDNEF 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	236/365 (65%)
RPD3	NP_014069.1	RPD3-like	18..392	CDD:212528	240/373 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	443	1.000	Domainoid score	I64
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68426
Inparanoid	1	1.050	561	1.000	Inparanoid score	I160
Isobase	1	0.950	-	0	Normalized mean entropy	S54
OMA	1	1.010	-	-		QHG54588
OrthoFinder	1	1.000	-	-		FOG0000617
OrthoInspector	1	1.000	-	-		oto100133
orthoMCL	1	0.900	-	-		OOG6_100248
Panther	1	1.100	-	-	O	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R212
SonicParanoid	1	1.000	-	-		X1095
TreeFam	0	0.000	Not matched by this tool.
	14	13.850