Protein Alignment HDAC1 and HOS2

DIOPT Version :9

• Sequence 1: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_011321.1
• Gene: HOS2 / 852681
• SGDID: S000003162
• Length: 452
• Species: Saccharomyces cerevisiae
• Alignment Length: 421
• Identity: 214/421 - (50%)
• Similarity: 295/421 - (70%)
• Gaps: 22/421 - (5%)

  Fly     8 RVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVR 72
            ||.|:::|.:.:|:||..|||||.|:.:|.:|:.:|||::.|::|....||.||:.:|||::||.
Yeast    27 RVSYHFNSKVSHYHYGVKHPMKPFRLMLTDHLVSSYGLHKIMDLYETRSATRDELLQFHSEDYVN 91

  Fly    73 FLRSIRPDNMSEYNK-QMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWGGG 136
            ||..:.|:|.::..: .::.||:|:|||:|..||::..|..|.|:.|..||....|:|.|||.||
Yeast    92 FLSKVSPENANKLPRGTLENFNIGDDCPIFQNLYDYTTLYTGASLDATRKLINNQSDIAINWSGG 156

  Fly   137 LHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKY-G 200
            ||||||:..|||||||||||.||.||:||.|:||||||:||||||:|||||||||.|:||||| |
Yeast   157 LHHAKKNSPSGFCYVNDIVLSILNLLRYHPRILYIDIDLHHGDGVQEAFYTTDRVFTLSFHKYNG 221

  Fly   201 EYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSLT 265
            |:|||||||.:||..|||::|:|:||.||:|||:|.::|..|:..::.||:|..:|.|||||||.
Yeast   222 EFFPGTGDLTEIGCDKGKHFALNVPLEDGIDDDSYINLFKSIVDPLIMTFKPTLIVQQCGADSLG 286

  Fly   266 GDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYET----SVALAVEIANEL 326
            .||||||||.:|.||:||:|||.:.||.|:|||||||.|||||.|||||    .|.|..:|..::
Yeast   287 HDRLGCFNLNIKAHGECVKFVKSFGLPMLVVGGGGYTPRNVSRLWTYETGILNDVLLPEDIPEDI 351

  Fly   327 PYNDYFEYFGPDFKLHISPSNM-TNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQA--IP----- 383
            |:.|   .||||:.|:....:: .|:|:.:.||.|:.|..||:|.|..||.|::.|  ||
Yeast   352 PFRD---SFGPDYSLYPMLDDLYENKNSKKLLEDIRIRCLENIRYLQGAPSVRMDAECIPTQDIS 413

  Fly   384 -----EDAINDESDDEDKVDKDDRLPQSDKD 409
                 ||.|..|.::|.:.|..:||.:.:|:
Yeast   414 ALTEEEDKIIQEMNEETEADSSNRLEEMEKE 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	198/370 (54%)
HOS2	NP_011321.1	HDAC_Hos2	28..338	CDD:212540	178/309 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S54
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000617
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100248
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.660