Protein Alignment HDAC1 and Hdac3

DIOPT Version :10

• Sequence 1: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_445900.2
• Gene: Hdac3 / 84578
• RGDID: 619977
• Length: 428
• Species: Rattus norvegicus
• Alignment Length: 422
• Identity: 242/422 - (57%)
• Similarity: 328/422 - (77%)
• Gaps: 5/422 - (1%)

  Fly     7 KRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYV 71
            |.|.|:||.|:||::||.||||||||:.:||:|:|:||||:||.:::|::|:..:|.:|||::|:
  Rat     3 KTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYI 67

  Fly    72 RFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWGGG 136
            .||:.:.|.||..:.|.:..||||:|||||.||:|||....|.|:..|.:||.:..:|.|||.||
  Rat    68 DFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGG 132

  Fly   137 LHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGE 201
            ||||||.||||||||||||:|||||||||.||||||||:||||||:||||.|||||||||||||.
  Rat   133 LHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGN 197

  Fly   202 Y-FPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSLT 265
            | ||||||:.::||..|:||.:|:|||||:||.:|:.:|.|:||:|::.:||..:|||||||||.
  Rat   198 YFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVISQVVDFYQPTCIVLQCGADSLG 262

  Fly   266 GDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANELPYND 330
            .||||||||:::|||:|||:||.:|:|.|::||||||:|||:||||||||:.:...|:.||||::
  Rat   263 CDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSE 327

  Fly   331 YFEYFGPDFKLHISPS-NMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDESDDE 394
            |||||.|||.||...| .:.|||:.:||::|:..:||||:||.|||.|||..:|.|.:.  .|..
  Rat   328 YFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLT--YDRT 390

  Fly   395 DKVDKDDRLPQSDKDKRIVPENEYSDSEDEGE 426
            |:.|.::|.|:.:..:...| ||:.|.:.:.:
  Rat   391 DEADAEERGPEENYSRPEAP-NEFYDGDHDND 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:450134	224/366 (61%)
Hdac3	NP_445900.2	HDAC3	3..383	CDD:212529	232/379 (61%)
		Histone deacetylase	3..316		197/312 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..428		9/35 (26%)