DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC1 and Hdac2

DIOPT Version :9

Sequence 1:	NP_647918.2	Gene:	HDAC1 / 38565	FlyBaseID:	FBgn0015805	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_445899.1	Gene:	Hdac2 / 84577	RGDID:	619976	Length:	488	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	370/487 - (75%)
Similarity:	421/487 - (86%)	Gaps:	4/487 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QSHSKKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFH 66
            |...||:||||||.||||||||||||||||||||||||||||||||||||||||||||:||||:|
  Rat     5 QGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYH 69

  Fly    67 SDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICI 131
            ||||::|||||||||||||:||||||||||||||||||:||||||.|||||.|||||:|.:::.:
  Rat    70 SDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAV 134

  Fly   132 NWGGGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSF 196
            ||.||||||||||||||||||||||.:||||||||||||||||:|||||||||||||||||||||
  Rat   135 NWAGGLHHAKKSEASGFCYVNDIVLAVLELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSF 199

  Fly   197 HKYGEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGA 261
            |||||||||||||||||||||||||||.|:|||:||::|..||.||||||||.:||:||||||||
  Rat   200 HKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGA 264

  Fly   262 DSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANEL 326
            |||:||||||||||||||.||||.||.:|||.||:||||||||||:|||||||:|||..||.|||
  Rat   265 DSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNEL 329

  Fly   327 PYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDES 391
            |||||||||||||||||||||||||||.||:||||.||||||||||||||||:|||||||::::|
  Rat   330 PYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDS 394

  Fly   392 DDEDKVDKDDRLPQSDKDKRIVPENEYSDSEDEGEGGRRDNRSYKGQRKRPRLDKDTNSNKASSE 456
            .|||..|.|.|:.....||||..:.|:||||||||||||:...:|...|:.|:::|   .|.:.:
  Rat   395 GDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEED---KKEAED 456

  Fly   457 TSSEIKDEKEKGDGADGEESTASNTNSNNNSN 488
            ..:::|:|.:..|.: ||::......|...:|
  Rat   457 KRTDVKEEDKSKDNS-GEKTDTKGAKSEQLNN 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	318/366 (87%)
Hdac2	NP_445899.1	PTZ00063	9..398	CDD:240251	335/388 (86%)
Hdac2	NP_445899.1	HDAC2	9..374	CDD:212535	317/364 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353503
Domainoid	1	1.000	553	1.000	Domainoid score	I238
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	789	1.000	Inparanoid score	I488
OMA	1	1.010	-	-		QHG54588
OrthoDB	1	1.010	-	-		D267420at33208
OrthoFinder	1	1.000	-	-		FOG0000617
OrthoInspector	1	1.000	-	-		otm46124
orthoMCL	1	0.900	-	-		OOG6_100248
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1095
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770