Protein Alignment HDAC1 and Hdac1l

DIOPT Version :10

• Sequence 1: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_445898.1
• Gene: Hdac1l / 84576
• RGDID: 619975
• Length: 484
• Species: Rattus norvegicus
• Alignment Length: 480
• Identity: 362/480 - (75%)
• Similarity: 413/480 - (86%)
• Gaps: 8/480 - (1%)

  Fly     5 SKKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDE 69
            ::::||||||.|:||||||||||||||||||||||||||||||||||||||||.|:||||:|||:
  Rat     7 TERKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDD 71

  Fly    70 YVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWG 134
            |::|||||||||||||:||||||||||||||||||:||||||.|||||:|||||||.::|.:||.
  Rat    72 YIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWA 136

  Fly   135 GGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHH--GDGVEEAFYTTDRVMTVSFH 197
            ||||:|||||||||||||||||.|||||||||||||||||:||  ||||||||||||||||||||
  Rat   137 GGLHYAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGDGVEEAFYTTDRVMTVSFH 201

  Fly   198 KYGEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGAD 262
            ||||||||||||||||||||||||||.|||||:||::||:||.|::|||||.|||:|||||||:|
  Rat   202 KYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSD 266

  Fly   263 SLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANELP 327
            ||:||||||||||:|||.|||||||.:|||.||:||.||||.||:|||||||:|||..||.||||
  Rat   267 SLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGDGYTIHNVARCWTYETAVALDTEIPNELP 331

  Fly   328 YNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDESD 392
            ||||||||||||||||||||||||||:|||||||.|||||||||||.||||:||||||||.:||.
  Rat   332 YNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHTPGVQMQAIPEDAIPEESG 396

  Fly   393 DEDKVDKDDRLPQSDKDKRIVPENEYSDSEDEGEGGRRDNRSYKGQRKRPRL----DKDTNSNKA 453
            |||:.|.|..:.....||.|..|.|:.||::||||||.::.::| :.||.:.    :||....|.
  Rat   397 DEDEEDPDKPISICSSDKCIACEEEFPDSDEEGEGGRENSSNFK-KAKRVKTEDEKEKDPEEKKE 460

  Fly   454 SSETSSEIKDEKEKGDGADGEESTA 478
            .:| ..:.|:||.:..|...|...|
  Rat   461 VTE-EEKTKEEKPEAKGVKEEVKMA 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:450134	314/368 (85%)
Hdac1l	NP_445898.1	Arginase_HDAC	4..376	CDD:450134	314/368 (85%)