Protein Alignment HDAC1 and HDA18

DIOPT Version :10

• Sequence 1: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_200915.2
• Gene: HDA18 / 836228
• AraportID: AT5G61070
• Length: 682
• Species: Arabidopsis thaliana
• Alignment Length: 526
• Identity: 122/526 - (23%)
• Similarity: 222/526 - (42%)
• Gaps: 110/526 - (20%)

  Fly     5 SKKRVCYYYDS-----DIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTK 64
            |:::|...||.     |..|   |:.....|.|||:....|...|:.::..:....||....:..
plant    56 SQRKVGLVYDETMCKHDTPN---GKVDVECPDRIRVIWEKLQLAGVTQRCVVLGGSKAEDKHLKL 117

  Fly    65 FHSDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAA------AVKLN 123
            .|:.::|..::||     |...|..:|..:...   .|.:|    |:.|.|.||      .||:.
plant   118 VHTKKHVNLVKSI-----STKKKDSRRNKIASQ---LDSIY----LNGGSSEAAYLAAGSVVKVA 170

  Fly   124 KQASEICINWGGGL-----HHAKKSEASGFCYVNDIVLGILELLKYH-----QRVLYIDIDVHHG 178
            ::.:|..::.|..:     |||:..||.|||..|::.:....||...     :::|.:|.|:|||
plant   171 EKVAEGELDCGFAIVRPPGHHAESDEAMGFCLFNNVAVAASFLLNERPDLDVKKILIVDWDIHHG 235

  Fly   179 DGVEEAFYTTDRVMTVSFHK--YGEYFP--GTGDLRDIGAGKGKYYAVNIPLRDGMDDDA-YESI 238
            :|.::.|:...||:..|.|:  :|.::|  ..||...:|.|.|:.:.:|:|...|...|| |.::
plant   236 NGTQKMFWKDSRVLIFSVHRHDHGSFYPFGDDGDFNMVGEGPGEGFNINVPWEQGGCGDADYLAV 300

  Fly   239 FVPIISKVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHG----KCVEFVKKYNLPFLMVGGG 299
            :..|:..|.:.|:|..::|..|.|:..||.||...:|..|:.    |.:||.   :...::...|
plant   301 WNHILIPVTKEFKPDIILLSAGFDAAIGDPLGGCCVTPYGYSVMLKKLMEFA---HGKIVLALEG 362

  Fly   300 GYTIRNVSRCWTYETSVALAVEIANELPYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRL 364
            ||.:.::.:     :|:| .|::..|            |.::|.|......::|...::.::.||
plant   363 GYNLESLGK-----SSLA-CVQVLLE------------DKQIHGSSETYPLESTRRVIQAVRERL 409

  Fly   365 FENLRMLPHAPGVQIQAIPEDAINDESDDEDKVD---------------KDDRLPQSDKDKRIVP 414
                  ..:.|.:.......:.:.:.|.:.:..|               :|..|....|:.: ..
plant   410 ------CTYWPSLDASMASNENLKNPSAERNSADALLREVEELKSLMAARDGELEARRKELK-AK 467

  Fly   415 ENEYSDSEDEGEGG------RRD--------NRSYKGQR-----KRPRLDKDTNSNKASSETSSE 460
            ..|...:|.|.|.|      |.|        ..|.:.:|     |..|:||:...::|.|:   |
plant   468 NKELEANEKELEAGLMLIRAREDVICGLHAKIESLQQERDEAVAKAERIDKELQEDRARSQ---E 529

  Fly   461 IKDEKE 466
            .|::.|
plant   530 FKEDTE 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:450134	98/396 (25%)
HDA18	NP_200915.2	Arginase_HDAC	64..416	CDD:450134	97/393 (25%)
		SMC_prok_B	<433..>608	CDD:274008	22/107 (21%)