DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC1 and hdac4

DIOPT Version :9

Sequence 1:	NP_647918.2	Gene:	HDAC1 / 38565	FlyBaseID:	FBgn0015805	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_005172586.1	Gene:	hdac4 / 568877	ZFINID:	ZDB-GENE-061013-95	Length:	1052	Species:	Danio rerio

Alignment Length:	463	Identity:	117/463 - (25%)
Similarity:	198/463 - (42%)	Gaps:	90/463 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSHSKKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKF 65
            ||.|.    |...:|:|        ||....||:...:.|...||..:.|..|..|||.:|:...
Zfish   636 MQKHQ----CMCGNSNI--------HPEHAGRIQSIWSRLQETGLRGQCECIRGRKATLEELQTV 688

  Fly    66 HSDEYVRF-----LRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLN-- 123
            ||:.:|..     ||.....:::....::....:|.|.   |.::.....|:...:|....::
Zfish   689 HSEAHVLLYGTNPLRQKLDSSVTPMFVRLPCGGIGVDS---DTIWNEVHSSSAARLAVGSVVDLV 750

  Fly   124 -KQASEICINWGGGL-----------HHAKKSEASGFCYVNDIVLGILELLKYH---QRVLYIDI 173
             |.||       |.|           |||::|...||||.|.:.:. .:||:..   .::|.:|.
Zfish   751 FKVAS-------GELRNGFAVVRPPGHHAEESTPMGFCYFNSVAIA-AKLLQQRLNVSKILIVDW 807

  Fly   174 DVHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNIPLRDG----MDD 232
            |||||:|.::|||:...|:.:|.|:|  |.:|||:|...::|.|.|..:.||:....|    |.|
Zfish   808 DVHHGNGTQQAFYSDPNVLYLSLHRYDDGNFFPGSGAPDEVGIGPGVGFNVNMAFTGGLEPPMGD 872

  Fly   233 DAYESIFVPIISKVMETFQPAAVVLQCGADSLTG--DRLGCFNLTVKGHGKCVEFVKKYNLPFLM 295
            ..|.:.|..::..:...|.|..|::..|.|::.|  ..||.:.||    .||..::.|..:.  :
Zfish   873 ADYLAAFRSVVMPIANEFSPDVVLVSSGFDAVEGHPPPLGGYKLT----AKCFGYLTKQLMG--L 931

  Fly   296 VGG-------GGYTIRNVSRCWTYETSVALAVEIANEL-PYNDYFEYFGPDFKLHISPSNMTNQN 352
            .||       ||:.:..:  |...|..|:..  :.||| |.        |:..|...|    |.|
Zfish   932 AGGRLVLALEGGHDLTAI--CDASEACVSAL--LGNELDPI--------PEDILQQRP----NAN 980

  Fly   353 TSEYLEK---IKNRLFENLRMLPHAPGVQIQAIPEDAINDESDDEDKVDKDDRLPQSDKDKRIVP 414
            ..:.:||   ::::.:.:|:......|..::    :|...|:::.:.|.....|..::|.....|
Zfish   981 AIQSMEKVLEVQSKYWRSLQRSVSTLGYSLR----EAQRCENEEAETVTAMASLSVANKHMGKRP 1041

  Fly   415 ENEYSDSE 422
            |.|..:.|
Zfish  1042 EEEPMEEE 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	104/407 (26%)
hdac4	XP_005172586.1	ClassIIa_HDAC4_Gln-rich-N	62..151	CDD:197398
		PKK	68..187	CDD:289257
		Arginase_HDAC	623..1025	CDD:302587	110/437 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910