DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC1 and hdac6

DIOPT Version :9

Sequence 1:	NP_647918.2	Gene:	HDAC1 / 38565	FlyBaseID:	FBgn0015805	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_009302026.1	Gene:	hdac6 / 565482	ZFINID:	ZDB-GENE-030131-3232	Length:	1081	Species:	Danio rerio

Alignment Length:	517	Identity:	128/517 - (24%)
Similarity:	210/517 - (40%)	Gaps:	118/517 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 HPMKPHRIRMTHNLLLNYGLYRKME----IYRPHK-----ATADEMTKFHSDEYVRFLRSIRPDN 81
            ||..|.||..         ::.:.|    :.|.|:     ||.:|:...||.:::..::|
Zfish   463 HPELPQRISR---------IFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKS----- 513

  Fly    82 MSEYNKQMQRFNVGEDCPVFDGLY-----EFCQLSAGGSV---AAAVKLNKQASEICINWGGGLH 138
             ||:.|......:|::   ::.::     ..|.|.|.||.   |.|:...:..:.:.|....| |
Zfish   514 -SEHMKPRDLNRLGDE---YNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPG-H 573

  Fly   139 HAKKSEASGFCYVNDIVLGILELLKYHQ-------RVLYIDIDVHHGDGVEEAFYTTDRVMTVSF 196
            ||:|..|.|||:.|...|    ..:|.|       |||.:|.|||||:|.:..|...|.|:.:|.
Zfish   574 HAEKDTACGFCFFNTAAL----TARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISL 634

  Fly   197 HKY--GEYFPGTGDLR--DIGAGKGKYYAVNIPLRDG-MDDDAYESIFVPIISKVMETFQPAAVV 256
            |:|  |.:||.:.|..  .:|.|||:.|.||||...| |.|..|.:.|..::..:...|.|..|:
Zfish   635 HRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVL 699

  Fly   257 LQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVG------GGGYTIRNVSRCWTYETS 315
            :..|.|:..||.||.|.:|.:|:....     :.|..|..|      .|||.:.::|...:..||
Zfish   700 VSAGFDAARGDPLGGFQVTPEGYAHLT-----HQLMSLAAGRVLIILEGGYNLTSISESMSMCTS 759

  Fly   316 VALAVEIANELPYNDYFEYFGPDFKLHISP----SNMTNQNT----SEYLEKIKNRLFENLRM-L 371
            :.|    .:..|..|           |::|    :.::..|.    :.:...::..:.|:||: |
Zfish   760 MLL----GDSPPSLD-----------HLTPLKTSATVSINNVLRAHAPFWSSLRVNIPESLRLSL 809

  Fly   372 PH-------APGVQIQAIPEDAINDESDDEDKVDKDDRLPQSDKDKRI---------VPENEYSD 420
            |.       .||.:.:..|..:...:|..:    ...|..||..|:..         ...:..:.
Zfish   810 PSPKPKGKCTPGGKGKKSPRQSTPSQSPGQ----ATHRPDQSGFDELTADLLSLNLNTSTSSNTS 870

  Fly   421 SEDEGEGGRRDNRSYKGQRKRPRLDKDTNSNKASSETSSEIKDEKEKGDGADGEESTASNTN 482
            .|....||.|       ::.:|    :|:...|..|:.|.:|...||....|..:..|...|
Zfish   871 PESVAVGGAR-------RKVKP----NTHRVSAGLESESPLKLNPEKAGAGDDTDVKAETPN 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	103/389 (26%)
hdac6	XP_009302026.1	HDAC6-dom1	76..412	CDD:212545
		HDAC6-dom2	448..798	CDD:212527	100/377 (27%)
		zf-UBP	999..1061	CDD:280334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810