DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC1 and Hdac7

DIOPT Version :9

Sequence 1:	NP_647918.2	Gene:	HDAC1 / 38565	FlyBaseID:	FBgn0015805	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_036015418.1	Gene:	Hdac7 / 56233	MGIID:	1891835	Length:	977	Species:	Mus musculus

Alignment Length:	358	Identity:	91/358 - (25%)
Similarity:	145/358 - (40%)	Gaps:	80/358 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 YDSDIGNYYYGQG----HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVRF 73
            |||.:..:....|    ||....||:...:.|...||..:.|..|..||:.:|:...||:.:|..
Mouse   550 YDSVMLKHQCSCGDNSKHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLL 614

  Fly    74 -----LRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGG-SVAAAVKLNKQASEICIN 132
                 |..::.||........||              .|..|..|| .|......|:..|.....
Mouse   615 YGTNPLSRLKLDNGKLTGLLAQR--------------TFVMLPCGGVGVDTDTIWNELHSSNAAR 665

  Fly   133 WGGGL------------------------HHAKKSEASGFCYVNDIVLGILELLKYHQ--RVLYI 171
            |..|.                        |||..|.|.|||:.|.:.:...:|.::.:  ::|.:
Mouse   666 WAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQHGKASKILIV 730

  Fly   172 DIDVHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMD--- 231
            |.|||||:|.::.||....|:.:|.|::  |.:|||:|.:.::|.|.|:.:.||:....|:|
Mouse   731 DWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGTGSGEGFNVNVAWAGGLDPPM 795

  Fly   232 -DDAYESIFVPIISKVMETFQPAAVVLQCGADSLTGD--RLGCFNLTVKGHGKCVEFVKKYNLPF 293
             |..|.:.|..::..:...|.|..|::..|.|:..|.  .||.::::.|..|        |....
Mouse   796 GDPEYLAAFRIVVMPIAREFAPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFG--------YMTQQ 852

  Fly   294 LMVGGGGYTIRNVSRCWTYETSVALAVEIANEL 326
            ||...||              :|.||:|..::|
Mouse   853 LMNLAGG--------------AVVLALEGGHDL 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	91/358 (25%)
Hdac7	XP_036015418.1	PHA03247	<124..527	CDD:223021
Hdac7	XP_036015418.1	HDAC7	546..921	CDD:212532	91/358 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810