Protein Alignment HDAC1 and Hdac1

DIOPT Version :9

• Sequence 1: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_032254.1
• Gene: Hdac1 / 433759
• MGIID: 108086
• Length: 482
• Species: Mus musculus
• Alignment Length: 478
• Identity: 370/478 - (77%)
• Similarity: 420/478 - (87%)
• Gaps: 6/478 - (1%)

  Fly     5 SKKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDE 69
            :|::||||||.|:||||||||||||||||||||||||||||||||||||||||.|:||||:|||:
Mouse     7 TKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDD 71

  Fly    70 YVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWG 134
            |::|||||||||||||:||||||||||||||||||:||||||.|||||:|||||||.::|.:||.
Mouse    72 YIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWA 136

  Fly   135 GGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKY 199
            ||||||||||||||||||||||.|||||||||||||||||:||||||||||||||||||||||||
Mouse   137 GGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY 201

  Fly   200 GEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSL 264
            ||||||||||||||||||||||||.|||||:||::||:||.|::|||||.|||:|||||||:|||
Mouse   202 GEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSL 266

  Fly   265 TGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANELPYN 329
            :||||||||||:|||.|||||||.:|||.||:||||||||||:|||||||:|||..||.||||||
Mouse   267 SGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYN 331

  Fly   330 DYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDESDDE 394
            ||||||||||||||||||||||||:|||||||.||||||||||||||||:||||||||.:||.||
Mouse   332 DYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDE 396

  Fly   395 DKVDKDDRLPQSDKDKRIVPENEYSDSEDEGEGGRRDNRSYKGQRKRPRL----DKDTNSNKASS 455
            |:.|.|.|:.....||||..|.|:|||::||||||:::.::| :.||.:.    :||....|..:
Mouse   397 DEEDPDKRISICSSDKRIACEEEFSDSDEEGEGGRKNSSNFK-KAKRVKTEDEKEKDPEEKKEVT 460

  Fly   456 ETSSEIKDEKEKGDGADGEESTA 478
            | ..:.|:||.:..|...|...|
Mouse   461 E-EEKTKEEKPEAKGVKEEVKLA 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	318/366 (87%)
Hdac1	NP_032254.1	HDAC1	4..374	CDD:212534	318/366 (87%)
		Histone deacetylase	9..321		269/311 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	390..482		35/93 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	553	1.000	Domainoid score	I249
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68426
Inparanoid	1	1.050	789	1.000	Inparanoid score	I515
Isobase	1	0.950	-	0	Normalized mean entropy	S54
OMA	1	1.010	-	-		QHG54588
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000617
OrthoInspector	1	1.000	-	-		otm44034
orthoMCL	1	0.900	-	-		OOG6_100248
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R212
SonicParanoid	1	1.000	-	-		X1095
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810