Protein Alignment HDAC1 and hdac3

DIOPT Version :10

• Sequence 1: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_957284.1
• Gene: hdac3 / 393965
• ZFINID: ZDB-GENE-040426-847
• Length: 428
• Species: Danio rerio
• Alignment Length: 421
• Identity: 241/421 - (57%)
• Similarity: 325/421 - (77%)
• Gaps: 9/421 - (2%)

  Fly     8 RVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVR 72
            |..|:||.|:||::||.||||||||:.:||:|:|:||||:||.:::|:||:..:|.:|||::|:.
Zfish     4 RTAYFYDPDVGNFHYGAGHPMKPHRLSLTHSLVLHYGLYKKMMVFKPYKASQHDMCRFHSEDYID 68

  Fly    73 FLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWGGGL 137
            ||:.:.|:||..:.|.:..||||.|||||.||:|||....|.|:..|.:||.:..:|.|||.|||
Zfish    69 FLQKVSPNNMQGFTKSLNTFNVGGDCPVFPGLFEFCSRYTGASLQGATQLNHKICDIAINWAGGL 133

  Fly   138 HHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEY 202
            |||||.||||||||||||:.||||||||.||||||||:||||||:||||.|||||||||||||.|
Zfish   134 HHAKKFEASGFCYVNDIVISILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNY 198

  Fly   203 -FPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSLTG 266
             ||||||:.::||..|:||.:|:|||||:||.:|..:|.|:|.:|::.:||..:|||||||||..
Zfish   199 FFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYRQLFQPVIKQVVDFYQPTCIVLQCGADSLGC 263

  Fly   267 DRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANELPYNDY 331
            ||||||||:::|||:||||||.:.:|.|::||||||:|||:||||:|||:.:...|::||||::|
Zfish   264 DRLGCFNLSIRGHGECVEFVKGFKIPLLVLGGGGYTVRNVARCWTFETSLLVEESISDELPYSEY 328

  Fly   332 FEYFGPDFKLHISPS-NMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDESDDED 395
            ||||.|||.||...| .:.|||:.:|||:|:..:||||:||.|||.|||:.:|.|.::.|..||
Zfish   329 FEYFAPDFTLHPDVSTRIENQNSRQYLEQIRQTVFENLKMLNHAPSVQIRDVPSDLLSYERPDE- 392

  Fly   396 KVDKDDRLPQSDKDKRIVPE--NEYSDSEDE 424
             .|.::|..:.:..:   ||  ||:.|.:.:
Zfish   393 -ADPEERGSEENFSR---PEAANEFYDGDHD 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:450134	222/365 (61%)
hdac3	NP_957284.1	HDAC3	3..383	CDD:212529	230/378 (61%)
		Histone deacetylase	3..316		194/311 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	381..428		12/44 (27%)