Protein Alignment HDAC1 and HDAC4

DIOPT Version :9

• Sequence 1: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Alignment Length: 445
• Identity: 106/445 - (23%)
• Similarity: 179/445 - (40%)
• Gaps: 106/445 - (23%)

  Fly    26 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVRFLRS-----IRPDNMSEY 85
            ||....|::.....|....|.::.:..|..|||.:|:...|::.:.....|     .||...:..
  Fly   860 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTL 924

  Fly    86 NKQMQRFNVGEDCPVFDGLYE------FCQLSAGGSVAAAVKLNKQASEICINWGGGL------- 137
            :....|.:.|......|..:.      ..:::||..:..|:|..|          |.|
  Fly   925 SASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAK----------GDLRNGFAVV 979

  Fly   138 ----HHAKKSEASGFCYVNDIVLGILELLKYH----QRVLYIDIDVHHGDGVEEAFYTTDRVMTV 194
                |||:.:.|.|||:.|.|.:. .:||:..    :|:|.:|.|||||:|.::|||.:..::.:
  Fly   980 RPPGHHAEANLAMGFCFFNSIAIA-AKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYL 1043

  Fly   195 SFHKY--GEYFPGTGDLRDIGAGKGKYYAVNI----PLRDGMDDDAYESIFVPIISKVMETFQPA 253
            |.|::  |.:|||||...:.|:|.|..:.|||    .|...:.|..|.:.|..::..:..:|.|.
  Fly  1044 SIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPD 1108

  Fly   254 AVVLQCGADSLTGD--RLG-------CFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRC 309
            .|::..|.|:.||.  .||       ||....:      |.::..|...::...|||.:..:  |
  Fly  1109 IVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR------ELLQLANGKVVLALEGGYDLAAI--C 1165

  Fly   310 WTYETSV-AL----AVEIANELPYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEK---IKNRLFE 366
            .:.:..| ||    |..||..              :|...|.    ||....|:|   |:...:.
  Fly  1166 DSAQECVRALLGDPAAPIAKA--------------ELERPPC----QNAINTLQKTIAIQQTHWP 1212

  Fly   367 NLRMLPHAPG------VQIQAIPEDAIN--------------DESDDEDKVDKDD 401
            .:|||.|..|      ::::....:.||              ...|.|:.:|:|:
  Fly  1213 CVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQDE 1267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	97/394 (25%)
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
		HDAC_classIIa	837..1211	CDD:212544	95/387 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458014
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48252
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840