DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC1 and HDAC1

DIOPT Version :9

Sequence 1:	NP_647918.2	Gene:	HDAC1 / 38565	FlyBaseID:	FBgn0015805	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_004955.2	Gene:	HDAC1 / 3065	HGNCID:	4852	Length:	482	Species:	Homo sapiens

Alignment Length:	478	Identity:	370/478 - (77%)
Similarity:	420/478 - (87%)	Gaps:	6/478 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SKKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDE 69
            ::::||||||.|:||||||||||||||||||||||||||||||||||||||||.|:||||:|||:
Human     7 TRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDD 71

  Fly    70 YVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWG 134
            |::|||||||||||||:||||||||||||||||||:||||||.|||||:|||||||.::|.:||.
Human    72 YIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWA 136

  Fly   135 GGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKY 199
            ||||||||||||||||||||||.|||||||||||||||||:||||||||||||||||||||||||
Human   137 GGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY 201

  Fly   200 GEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSL 264
            ||||||||||||||||||||||||.|||||:||::||:||.|::|||||.|||:|||||||:|||
Human   202 GEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSL 266

  Fly   265 TGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANELPYN 329
            :||||||||||:|||.|||||||.:|||.||:||||||||||:|||||||:|||..||.||||||
Human   267 SGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYN 331

  Fly   330 DYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDESDDE 394
            ||||||||||||||||||||||||:|||||||.||||||||||||||||:||||||||.:||.||
Human   332 DYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDE 396

  Fly   395 DKVDKDDRLPQSDKDKRIVPENEYSDSEDEGEGGRRDNRSYKGQRKRPRL----DKDTNSNKASS 455
            |:.|.|.|:.....||||..|.|:||||:||||||:::.::| :.||.:.    :||....|..:
Human   397 DEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFK-KAKRVKTEDEKEKDPEEKKEVT 460

  Fly   456 ETSSEIKDEKEKGDGADGEESTA 478
            | ..:.|:||.:..|...|...|
Human   461 E-EEKTKEEKPEAKGVKEEVKLA 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	317/366 (87%)
HDAC1	NP_004955.2	HDAC1	4..374	CDD:212534	317/366 (87%)
		Histone deacetylase	9..321		269/311 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..482		37/95 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	553	1.000	Domainoid score	I247
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68426
Inparanoid	1	1.050	791	1.000	Inparanoid score	I518
Isobase	1	0.950	-	0	Normalized mean entropy	S54
OMA	1	1.010	-	-		QHG54588
OrthoDB	1	1.010	-	-		D267420at33208
OrthoFinder	1	1.000	-	-		FOG0000617
OrthoInspector	1	1.000	-	-		otm41985
orthoMCL	1	0.900	-	-		OOG6_100248
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R212
SonicParanoid	1	1.000	-	-		X1095
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820