DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC1 and clr6

DIOPT Version :9

Sequence 1:	NP_647918.2	Gene:	HDAC1 / 38565	FlyBaseID:	FBgn0015805	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_595333.1	Gene:	clr6 / 2540368	PomBaseID:	SPBC36.05c	Length:	405	Species:	Schizosaccharomyces pombe

Alignment Length:	407	Identity:	246/407 - (60%)
Similarity:	312/407 - (76%)	Gaps:	6/407 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEY 70
            ||:|.|:||.|:|||:||..|||||||:||.|||::||.||.|:.:..|.:||.::||:.|:|||
pombe     5 KKKVSYFYDEDVGNYHYGPQHPMKPHRVRMVHNLVVNYNLYEKLNVITPVRATRNDMTRCHTDEY 69

  Fly    71 VRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWGG 135
            :.||..:.||.|.::.....:||||:||||||||||||.:|||||:.||.:||...:||.|||.|
pombe    70 IEFLWRVTPDTMEKFQPHQLKFNVGDDCPVFDGLYEFCSISAGGSIGAAQELNSGNAEIAINWAG 134

  Fly   136 GLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYG 200
            |||||||.|||||||||||.|..|||||||||||||||||||||||||.|||||||||.||||:|
pombe   135 GLHHAKKREASGFCYVNDIALAALELLKYHQRVLYIDIDVHHGDGVEEFFYTTDRVMTCSFHKFG 199

  Fly   201 EYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSLT 265
            |||||||.::|.|.|.||.||||:|||||:||::|||:|.|:||.:|:.|:|.||:||||.|||.
pombe   200 EYFPGTGHIKDTGIGTGKNYAVNVPLRDGIDDESYESVFKPVISHIMQWFRPEAVILQCGTDSLA 264

  Fly   266 GDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANELPYND 330
            |||||||||::|||..||:|||.:|||.:.|||||||:|||:|.|||||.:....|:...|||||
pombe   265 GDRLGCFNLSMKGHSMCVDFVKSFNLPMICVGGGGYTVRNVARVWTYETGLLAGEELDENLPYND 329

  Fly   331 YFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDESDDED 395
            |.:|:|||:||::..:||.|.||.:||:.|.:.:.||||.|..||.||:...|.| ...|:.::.
pombe   330 YLQYYGPDYKLNVLSNNMENHNTRQYLDSITSEIIENLRNLSFAPSVQMHKTPGD-FTFENAEKQ 393

  Fly   396 KVDKDDRLPQSDKDKRI 412
            .:.|::.:     |:|:
pombe   394 NIAKEEIM-----DERV 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	235/365 (64%)
clr6	NP_595333.1	PTZ00063	5..403	CDD:240251	244/403 (61%)
clr6	NP_595333.1	RPD3-like	5..379	CDD:212528	240/373 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	445	1.000	Domainoid score	I73
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68426
Inparanoid	1	1.050	549	1.000	Inparanoid score	I197
OMA	1	1.010	-	-		QHG54588
OrthoFinder	1	1.000	-	-		FOG0000617
OrthoInspector	1	1.000	-	-		oto101870
orthoMCL	1	0.900	-	-		OOG6_100248
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R212
SonicParanoid	1	1.000	-	-		X1095
TreeFam	0	0.000	Not matched by this tool.
	13	12.900