DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC1 and Hdac4

DIOPT Version :9

Sequence 1:	NP_647918.2	Gene:	HDAC1 / 38565	FlyBaseID:	FBgn0015805	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_006529374.1	Gene:	Hdac4 / 208727	MGIID:	3036234	Length:	1100	Species:	Mus musculus

Alignment Length:	379	Identity:	102/379 - (26%)
Similarity:	162/379 - (42%)	Gaps:	77/379 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVRFLRSIRPDNMSEYNKQMQ 90
            ||....||:...:.|...||..|.|..|..|||.:|:...||:.:. .|....|.|..:.:.:..
Mouse   691 HPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT-LLYGTNPLNRQKLDSKKL 754

  Fly    91 RFNVGEDCPVFDGLYEFCQLSAGG--------------------SVAAAVKLNKQASEICINWGG 135
               :|....|      |.:|..||                    :|...|:|..:.:...:..|.
Mouse   755 ---LGSLTSV------FVRLPCGGVGVDSDTIWNEVHSSGAARLAVGCVVELVFKVATGELKNGF 810

  Fly   136 GL-----HHAKKSEASGFCYVNDIVLGILELLKYH---QRVLYIDIDVHHGDGVEEAFYTTDRVM 192
            .:     |||::|...||||.|.:.:. .:||:..   .::|.:|.|||||:|.::|||....|:
Mouse   811 AVVRPPGHHAEESTPMGFCYFNSVAVA-AKLLQQRLNVSKILIVDWDVHHGNGTQQAFYNDPNVL 874

  Fly   193 TVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNIPLRDG----MDDDAYESIFVPIISKVMETFQ 251
            .:|.|:|  |.:|||:|...::|.|.|..:.||:....|    |.|..|.:.|..::..:...|.
Mouse   875 YMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLEPPMGDAEYLAAFRTVVMPIANEFA 939

  Fly   252 PAAVVLQCGADSLTG--DRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGG-------GGYTIRNVS 307
            |..|::..|.|::.|  ..||.:||:    .||..::.|..:.  :.||       ||:.:..:
Mouse   940 PDVVLVSSGFDAVEGHPTPLGGYNLS----AKCFGYLTKQLMG--LAGGRLVLALEGGHDLTAI- 997

  Fly   308 RCWTYETSVALAVEIANEL-PYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKI 360
             |...|..|:..  :.||| |.        |:..||..|    |.|....:||:
Mouse   998 -CDASEACVSAL--LGNELEPL--------PEKVLHQRP----NANAVHSMEKV 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	102/379 (27%)
Hdac4	XP_006529374.1	ClassIIa_HDAC4_Gln-rich-N	<104..165	CDD:197398
Hdac4	XP_006529374.1	HDAC4	665..1073	CDD:212530	102/379 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810