DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC1 and hdac1

DIOPT Version :9

Sequence 1:	NP_647918.2	Gene:	HDAC1 / 38565	FlyBaseID:	FBgn0015805	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_005159649.1	Gene:	hdac1 / 192302	ZFINID:	ZDB-GENE-020419-32	Length:	484	Species:	Danio rerio

Alignment Length:	517	Identity:	372/517 - (71%)
Similarity:	419/517 - (81%)	Gaps:	48/517 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SKKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDE 69
            :||:||||||.|:||||||||||||||||||||||||||||||||||||||||.|:||||:|||:
Zfish     8 TKKKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDD 72

  Fly    70 YVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWG 134
            |::|||||||||||||:||||||||||||||||||:||||||.|||||.|||||||.::|.|||.
Zfish    73 YIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNKQQTDIAINWA 137

  Fly   135 GGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKY 199
            ||||||||||||||||||||||.|||||||||||||||||:||||||||||||||||||||||||
Zfish   138 GGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY 202

  Fly   200 GEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSL 264
            ||||||||||||||||||||||||.|||||:||::||:||.||:|||||.:||:|||||||||||
Zfish   203 GEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPIMSKVMEMYQPSAVVLQCGADSL 267

  Fly   265 TGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANELPYN 329
            :||||||||||:|||.||||::|.:|||.||:||||||||||:||||:||:|||...|.||||||
Zfish   268 SGDRLGCFNLTIKGHAKCVEYMKSFNLPLLMLGGGGYTIRNVARCWTFETAVALDSTIPNELPYN 332

  Fly   330 DYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDESDDE 394
            ||||||||||||||||||||||||::||||||.||||||||||||||||:|||||||:.::|.||
Zfish   333 DYFEYFGPDFKLHISPSNMTNQNTNDYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAVQEDSGDE 397

  Fly   395 DKVDKDDRLPQSDKDKRIVPENEYSDSEDEGEGGRRDNRSYKGQRKRPRLDKDTNSNKASSETSS 459
            :. |.|.|:.....||||..:.|:|||||||:||||:..:|    |:|:
Zfish   398 ED-DPDKRISIRAHDKRIACDEEFSDSEDEGQGGRRNAANY----KKPK---------------- 441

  Fly   460 EIKDEKEKGDGADGEESTASNTN---SNNNSNNKSDNDAGATANAGSGSGSGSGAGAKGAKE 518
            .:|.|:||    ||||.....|:   ....|..|.|                    .||.||
Zfish   442 RVKTEEEK----DGEEKKGEPTDVKEEEKASEEKMD--------------------TKGPKE 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	316/366 (86%)
hdac1	XP_005159649.1	HDAC1	5..375	CDD:212534	316/366 (86%)
hdac1	XP_005159649.1	PTZ00063	8..406	CDD:240251	337/398 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	548	1.000	Domainoid score	I250
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	772	1.000	Inparanoid score	I519
OMA	1	1.010	-	-		QHG54588
OrthoDB	1	1.010	-	-		D267420at33208
OrthoFinder	1	1.000	-	-		FOG0000617
OrthoInspector	1	1.000	-	-		oto39943
orthoMCL	1	0.900	-	-		OOG6_100248
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1095
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840