Protein Alignment HDAC1 and hda-5

DIOPT Version :9

• Sequence 1: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_741051.1
• Gene: hda-5 / 174811
• WormBaseID: WBGene00009663
• Length: 508
• Species: Caenorhabditis elegans
• Alignment Length: 468
• Identity: 108/468 - (23%)
• Similarity: 180/468 - (38%)
• Gaps: 109/468 - (23%)

  Fly     5 SKKRVCYYYDSDIGNYYYGQGHPMK--------PHRIRMTHNLLLNYGLYRKMEIYRPHKATADE 61
            |.|...|.||..:      .||..|        |.|:::.:..|....|..........:|...|
 Worm     2 SSKPFGYVYDERM------LGHECKYDSTMAECPKRMKLIYERLQKDKLLDGAVKIDAREANDSE 60

  Fly    62 MTKFHSDEYVRFLRSIR-PDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQ 125
            :...|..:.:..:.|:. .:...||.|..:   :...|   :...|..:::.|||    ::|.|.
 Worm    61 IRLNHPQQLIDEIVSLNSTEKCEEYCKDKE---ILWTC---ENTNEAARVAIGGS----IELVKA 115

  Fly   126 ASEICINWGGGL-----HHAKKSEASGFCYVNDIVLG---ILELLKYHQRVLYIDIDVHHGDGVE 182
            |.|..|:.|..:     ||:....|.|:|..|::.:.   .:|.|:. ::|..:|.|.|.|:|..
 Worm   116 AMEGKIHNGFAMVRPPGHHSYGKVAQGYCIFNNVAIAAKYAIEKLEV-KKVAIVDFDYHAGNGTY 179

  Fly   183 EAFYTTDRVMTVSF--HKYGEYFPGTGDLRDIGAGKGKYYAVN------IPLRDGMDDDA-YESI 238
            ::.....|:...||  |.:|.::|.:.|..         ||.|      :||...|:.:. |.|:
 Worm   180 QSVKDESRIHLTSFHGHHFGAFWPFSRDYD---------YATNSQNTLFVPLNGTMNSEGDYVSV 235

  Fly   239 FVPIISKVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGK----------CVEFVKKYNLPF 293
            |..::..::|.|||..:::..|.||...|.:..|...||.||.          |...:
 Worm   236 FHHVLLPMLEQFQPELILISAGFDSGYYDVMMEFGQGVKAHGYGHMARLLSQICPGKI------- 293

  Fly   294 LMVGGGGYTIRNVSRCWTYETSVALAVEIANELPYNDYFEYFGP--DFKLHISPS------NMTN 350
            |.:..|||      ..:.|..|.::.|.....||.        |  |....||.:      |:.|
 Worm   294 LAILEGGY------HPYNYTESASMMVRGLLNLPL--------PRLDIPERISGALLETTWNILN 344

  Fly   351 QNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDESDDEDKVDK--DDRLPQSDKDKRIV 413
            .::..|     .:|.|.|::|.|..  :...:|:.|.:......:|:.|  ||.     |..|||
 Worm   345 HHSEWY-----PKLGERLKLLEHQQ--KELGLPQFAFDQTMFLGEKMRKMYDDM-----KKHRIV 397

  Fly   414 PENEY----SDSE 422
            ...|:    ||.:
 Worm   398 RTREWFPEMSDDQ 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	93/410 (23%)
hda-5	NP_741051.1	HDAC10_HDAC6-dom1	19..350	CDD:212526	82/371 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162757
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740