DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC1 and hda-2

DIOPT Version :9

Sequence 1:	NP_647918.2	Gene:	HDAC1 / 38565	FlyBaseID:	FBgn0015805	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_495678.1	Gene:	hda-2 / 174285	WormBaseID:	WBGene00001835	Length:	507	Species:	Caenorhabditis elegans

Alignment Length:	484	Identity:	208/484 - (42%)
Similarity:	307/484 - (63%)	Gaps:	37/484 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEY 70
            |:.|.|||..|:|:::|||.|||||.|:.:.::|:::|.:.:.|.:....|..|.:::.||:::|
Worm    28 KRNVAYYYHKDVGHFHYGQLHPMKPQRLVVCNDLVVSYEMPKYMTVVESPKLDAADISVFHTEDY 92

  Fly    71 VRFLRSIRPD-NMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWG 134
            |.||:::.|. .::..:..:::||:|||||:|.||:::|.|.|||||..|.:||.:.::|.|||.
Worm    93 VNFLQTVTPKLGLTMPDDVLRQFNIGEDCPIFAGLWDYCTLYAGGSVEGARRLNHKMNDIVINWP 157

  Fly   135 GGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKY 199
            |||||||||||||||||||||||||||||||:||||||||:||||||:|||..:|||||||||::
Worm   158 GGLHHAKKSEASGFCYVNDIVLGILELLKYHKRVLYIDIDIHHGDGVQEAFNNSDRVMTVSFHRF 222

  Fly   200 GEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSL 264
            |:||||:|.:.|.|.|.|||:|:|:||...:.|:.|..:|..:||.|.|.|.|.|:|||||:|||
Worm   223 GQYFPGSGSIMDKGVGPGKYFAINVPLMAAIRDEPYLKLFESVISGVEENFNPEAIVLQCGSDSL 287

  Fly   265 TGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANELPYN 329
            ..||||.|.|:...|.:.|::||....|.:::||||||:|||:|||..||.|.|.:.:.:|:|..
Worm   288 CEDRLGQFALSFNAHARAVKYVKSLGKPLMVLGGGGYTLRNVARCWALETGVILGLRMDDEIPGT 352

  Fly   330 D-YFEYFGPDFKLHISPS---NMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDE 390
            . |..||.|..   :.|:   .|.:.|::.||..|:......|||:..||.||:|.|    :...
Worm   353 SLYSHYFTPRL---LRPNLVPKMNDANSAAYLASIEKETLACLRMIRGAPSVQMQNI----VGIR 410

  Fly   391 SDDEDKVDKDDRLPQSDK---------------DKRIVPENEYSDSEDEGEGGRRDNRSYKGQRK 440
            .|:.:::::::||.:|.|               ::..|.|:....|...|:..||..:.:...|
Worm   411 LDEIEQIEENERLQKSSKSSIEYEVGKVSEKMEEECFVEEDSKPPSFPPGQDPRRIGQYWGYDR- 474

  Fly   441 RPRLDKDTNSNKASSETSSEIKDEKEKGD 469
                     |..|...:.|::.:|.:..|
Worm   475 ---------SGLAPPRSHSDVIEEAKYED 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	185/370 (50%)
hda-2	NP_495678.1	PTZ00063	28..430	CDD:240251	196/408 (48%)
hda-2	NP_495678.1	Arginase_HDAC	29..406	CDD:302587	189/379 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S54
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D267420at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100248
Panther	1	1.100	-	-	O	PTHR48252
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.770