Protein Alignment HDAC1 and Hdac10

DIOPT Version :10

• Sequence 1: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001403078.1
• Gene: Hdac10 / 170787
• MGIID: 2158340
• Length: 667
• Species: Mus musculus
• Alignment Length: 400
• Identity: 93/400 - (23%)
• Similarity: 175/400 - (43%)
• Gaps: 74/400 - (18%)

  Fly    30 PHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVRFLRSIRPDNMSEYNKQMQRFNV 94
            |.|:....:.|...||..:.......:|:.:|:...||.||:..::..:..:..|.:...:::|.
Mouse    28 PERLTAALDGLRQRGLEERCLCLSACEASEEELGLVHSPEYIALVQKTQTLDKEELHALSKQYNA 92

  Fly    95 GEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWGGGL-----HHAKKSEASGFCYVNDI 154
            ....|   ..:...:|:||    ||::|........::.|..|     ||::::.|:|||..|::
Mouse    93 VYFHP---DTFHCARLAAG----AALQLVDAVLTGAVHNGLALVRPPGHHSQRAAANGFCVFNNV 150

  Fly   155 VLGILELLKYH--QRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKY--GEYFP--GTGDLRDIG 213
            .|......:.:  ||:|.:|.|||||.|::..|.....|:..|:|:|  |.::|  ...|...:|
Mouse   151 ALAAKHAKQKYGLQRILIVDWDVHHGQGIQYIFNDDPSVLYFSWHRYEHGSFWPFLPESDADAVG 215

  Fly   214 AGKGKYYAVNIPLRD-GMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSLTGDRLGCFNLTVK 277
            .|:|:.:.||:|... ||.:..|.:.|:.::..:...|.|..|::..|.||..||..|....|
Mouse   216 QGQGQGFTVNLPWNQVGMGNADYLAAFLHVLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQAT-- 278

  Fly   278 GHGKCVEFVKKYNLPFLMVGG-------GGYTIRNVSR--CWTYETSV----------------A 317
              .:|  |.....|..::.||       |||.:.::::  |...:|.:                |
Mouse   279 --PEC--FAHLTQLLQVLAGGRICAVLEGGYHLESLAQSVCMMVQTLLGDPTPPLLGLMVPCQSA 339

  Fly   318 L----AVEIANELPYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQ 378
            |    :|:.| :.||       ....:.:::|...::.::.|.         .:||:|..:|..
Mouse   340 LESIQSVQTA-QTPY-------WTSLQQNVAPVLSSSTHSPEE---------RSLRLLGESPTC- 386

  Fly   379 IQAIPEDAIN 388
              |:.||:::
Mouse   387 --AVAEDSLS 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:450134	88/382 (23%)
Hdac10	NP_001403078.1	Histone deacetylase	1..323		78/307 (25%)
		Arginase_HDAC	18..354	CDD:450134	84/346 (24%)