DRSC/TRiP Functional Genomics Resources

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Protein Alignment HDAC1 and Hdac6

DIOPT Version :10

Sequence 1:NP_647918.2 Gene:HDAC1 / 38565 FlyBaseID:FBgn0015805 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_001398533.1 Gene:Hdac6 / 15185 MGIID:1333752 Length:1161 Species:Mus musculus


Alignment Length:532 Identity:125/532 - (23%)
Similarity:205/532 - (38%) Gaps:111/532 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MQSHSKKRVCYYYDSDIGNYYYGQGHPMKPHRIR--MTHNLLLNYGLYRKMEIYRPHKATADEMT 63
            |.||     |..:|:.         ||..|.||.  |.|  |...||..:..|.....|...|:.
Mouse   488 MMSH-----CNLWDNH---------HPETPQRILRIMCH--LEEVGLAARCLILPARPALDSELL 536

  Fly    64 KFHSDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGS--VAAAVKLNKQA 126
            ..||.|||..||:.......:.:::...|:....||   ..:...:|:.|.:  :..||...:..
Mouse   537 TCHSAEYVEHLRTTEKMKTRDLHREGANFDSIYICP---STFACAKLATGAACRLVEAVLSGEVL 598

  Fly   127 SEICINWGGGLHHAKKSEASGFCYVNDIVLGILELLKYHQ-------RVLYIDIDVHHGDGVEEA 184
            :.|.:....| |||:.:.|.|||:.|.:.:.    .::.|       |:|.:|.|||||:|.:..
Mouse   599 NGIAVVRPPG-HHAEPNAACGFCFFNSVAVA----ARHAQIIAGRALRILIVDWDVHHGNGTQHI 658

  Fly   185 FYTTDRVMTVSFHKY--GEYFP--GTGDLRDIGAGKGKYYAVNIPLR-DGMDDDAYESIFVPIIS 244
            |.....|:.||.|:|  |.:||  ..|....:|...|..:.||:|.. ..|.|..|.:.:..::.
Mouse   659 FEDDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRDAGIGFTVNVPWNGPRMGDADYLAAWHRLVL 723

  Fly   245 KVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVG----------GG 299
            .:...|.|..|::..|.|:..||.||...:|.:|:.         :|..|::|          .|
Mouse   724 PIAYEFNPELVLISAGFDAAQGDPLGGCQVTPEGYA---------HLTHLLMGLAGGRIILILEG 779

  Fly   300 GYTIRNVSRCWTYETSVALAVEIANELPYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRL 364
            ||.:.::|     |:..|....:..:.|         |...|...|.:....:.||.:: :..:.
Mouse   780 GYNLASIS-----ESMAACTHSLLGDPP---------PQLTLLRPPQSGALVSISEVIQ-VHRKY 829

  Fly   365 FENLRMLPHAPGVQIQAIPEDAINDESDDEDKVD-KDDRL----------PQSDKD----KRIVP 414
            :.:||::..                    |||.: ...||          |.|.|:    |..||
Mouse   830 WRSLRLMKM--------------------EDKEECSSSRLVIKKLPPTASPVSAKEMTTPKGKVP 874

  Fly   415 ENEYSDSEDEGEGGRRDNRSYKGQRKRPRLDKDTNSNKASSETSSEIKDEKEKGDGA--DGEEST 477
            |.....:.....|........|.:..:..|.:..:|.:|:..|:.::...||...||  |...|.
Mouse   875 EESVRKTIAALPGKESTLGQAKSKMAKAVLAQGQSSEQAAKGTTLDLATSKETVGGATTDLWASA 939

  Fly   478 ASNTNSNNNSNN 489
            |:..|..|.:.:
Mouse   940 AAPENFPNQTTS 951

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC1NP_647918.2 Arginase_HDAC 5..372 CDD:450134 95/392 (24%)
Hdac6NP_001398533.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..61
Nuclear export signal. /evidence=ECO:0000269|PubMed:10873806 66..75
Histone deacetylase 1 87..403
Arginase_HDAC 98..434 CDD:450134
Histone deacetylase 2 481..799 90/348 (26%)
HDAC6-dom2 484..834 CDD:212527 96/393 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 954..975
zf-UBP 1067..1128 CDD:460464
Ubiquitin binding. /evidence=ECO:0000250|UniProtKB:Q9UBN7 1088..1090
Ubiquitin binding. /evidence=ECO:0000250|UniProtKB:Q9UBN7 1116..1123
Blue background indicates that the domain is not in the aligned region.

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