Protein Alignment HDAC1 and Hdac6

DIOPT Version :9

• Sequence 1: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001123888.1
• Gene: Hdac6 / 15185
• MGIID: 1333752
• Length: 1149
• Species: Mus musculus
• Alignment Length: 532
• Identity: 125/532 - (23%)
• Similarity: 205/532 - (38%)
• Gaps: 111/532 - (20%)

  Fly     1 MQSHSKKRVCYYYDSDIGNYYYGQGHPMKPHRIR--MTHNLLLNYGLYRKMEIYRPHKATADEMT 63
            |.||     |..:|:.         ||..|.||.  |.|  |...||..:..|.....|...|:.
Mouse   488 MMSH-----CNLWDNH---------HPETPQRILRIMCH--LEEVGLAARCLILPARPALDSELL 536

  Fly    64 KFHSDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGS--VAAAVKLNKQA 126
            ..||.|||..||:.......:.:::...|:....||   ..:...:|:.|.:  :..||...:..
Mouse   537 TCHSAEYVEHLRTTEKMKTRDLHREGANFDSIYICP---STFACAKLATGAACRLVEAVLSGEVL 598

  Fly   127 SEICINWGGGLHHAKKSEASGFCYVNDIVLGILELLKYHQ-------RVLYIDIDVHHGDGVEEA 184
            :.|.:....| |||:.:.|.|||:.|.:.:.    .::.|       |:|.:|.|||||:|.:..
Mouse   599 NGIAVVRPPG-HHAEPNAACGFCFFNSVAVA----ARHAQIIAGRALRILIVDWDVHHGNGTQHI 658

  Fly   185 FYTTDRVMTVSFHKY--GEYFP--GTGDLRDIGAGKGKYYAVNIPLR-DGMDDDAYESIFVPIIS 244
            |.....|:.||.|:|  |.:||  ..|....:|...|..:.||:|.. ..|.|..|.:.:..::.
Mouse   659 FEDDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRDAGIGFTVNVPWNGPRMGDADYLAAWHRLVL 723

  Fly   245 KVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVG----------GG 299
            .:...|.|..|::..|.|:..||.||...:|.:|:.         :|..|::|          .|
Mouse   724 PIAYEFNPELVLISAGFDAAQGDPLGGCQVTPEGYA---------HLTHLLMGLAGGRIILILEG 779

  Fly   300 GYTIRNVSRCWTYETSVALAVEIANELPYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRL 364
            ||.:.::|     |:..|....:..:.|         |...|...|.:....:.||.:: :..:.
Mouse   780 GYNLASIS-----ESMAACTHSLLGDPP---------PQLTLLRPPQSGALVSISEVIQ-VHRKY 829

  Fly   365 FENLRMLPHAPGVQIQAIPEDAINDESDDEDKVD-KDDRL----------PQSDKD----KRIVP 414
            :.:||::..                    |||.: ...||          |.|.|:    |..||
Mouse   830 WRSLRLMKM--------------------EDKEECSSSRLVIKKLPPTASPVSAKEMTTPKGKVP 874

  Fly   415 ENEYSDSEDEGEGGRRDNRSYKGQRKRPRLDKDTNSNKASSETSSEIKDEKEKGDGA--DGEEST 477
            |.....:.....|........|.:..:..|.:..:|.:|:..|:.::...||...||  |...|.
Mouse   875 EESVRKTIAALPGKESTLGQAKSKMAKAVLAQGQSSEQAAKGTTLDLATSKETVGGATTDLWASA 939

  Fly   478 ASNTNSNNNSNN 489
            |:..|..|.:.:
Mouse   940 AAPENFPNQTTS 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	95/392 (24%)
Hdac6	NP_001123888.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..61
		Histone deacetylase 1	87..403
		Arginase_HDAC	98..434	CDD:418394
		Histone deacetylase 2	481..799		90/348 (26%)
		HDAC6-dom2	484..834	CDD:212527	96/393 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	954..975
		zf-UBP	1067..1129	CDD:396634
		Ubiquitin binding. /evidence=ECO:0000250|UniProtKB:Q9UBN7	1088..1090
		Ubiquitin binding. /evidence=ECO:0000250|UniProtKB:Q9UBN7	1116..1123

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810