Protein Alignment HDAC1 and Hdac5

DIOPT Version :10

• Sequence 1: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001392161.1
• Gene: Hdac5 / 15184
• MGIID: 1333784
• Length: 1133
• Species: Mus musculus
• Alignment Length: 342
• Identity: 94/342 - (27%)
• Similarity: 149/342 - (43%)
• Gaps: 63/342 - (18%)

  Fly    26 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVRFLRSIRPDNMSEYNKQMQ 90
            ||....||:...:.|...||..|.|..|..|||.||:...|| ||...|....|.|..:.:.:..
Mouse   715 HPEHAGRIQSIWSRLQETGLLGKCERIRGRKATLDEIQTVHS-EYHTLLYGTSPLNRQKLDSKKL 778

  Fly    91 RFNVGEDCPVFDGLYEFCQLSAGG-SVAAAVKLNKQASEICINWGGGL----------------- 137
               :|   |:...:|  ..|..|| .|.:....|:..|...:....|.
Mouse   779 ---LG---PISQKMY--AMLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLVELAFKVAAGELKNGF 835

  Fly   138 -------HHAKKSEASGFCYVNDIVLGILELLKYH---QRVLYIDIDVHHGDGVEEAFYTTDRVM 192
                   |||::|.|.|||:.|.:.: ..:||:..   .:||.:|.|:|||:|.::|||....|:
Mouse   836 AIIRPPGHHAEESTAMGFCFFNSVAI-TAKLLQQKLSVGKVLIVDWDIHHGNGTQQAFYNDPSVL 899

  Fly   193 TVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMD----DDAYESIFVPIISKVMETFQ 251
            .:|.|:|  |.:|||:|...::|.|.|..|.||:....|:|    |..|.:.|..::..:.:.|.
Mouse   900 YISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAQEFS 964

  Fly   252 PAAVVLQCGADSLTG--DRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGG-------GGYTIRNVS 307
            |..|::..|.|::.|  ..||.:::|.:..|.....:      ..:.||       ||:.:..:
Mouse   965 PDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQL------MTLAGGRVVLALEGGHDLTAI- 1022

  Fly   308 RCWTYETSVA--LAVEI 322
             |...|..|:  |:||:
Mouse  1023 -CDASEACVSALLSVEL 1038

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:450134	94/342 (27%)
Hdac5	NP_001392161.1	ClassIIa_HDAC_Gln-rich-N	87..174	CDD:421006
		HDAC5	690..1109	CDD:212531	94/342 (27%)