Protein Alignment HDAC1 and Hdac2

DIOPT Version :10

• Sequence 1: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_032255.2
• Gene: Hdac2 / 15182
• MGIID: 1097691
• Length: 488
• Species: Mus musculus
• Alignment Length: 487
• Identity: 372/487 - (76%)
• Similarity: 421/487 - (86%)
• Gaps: 4/487 - (0%)

  Fly     2 QSHSKKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFH 66
            |...||:||||||.||||||||||||||||||||||||||||||||||||||||||||:||||:|
Mouse     5 QGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYH 69

  Fly    67 SDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICI 131
            ||||::|||||||||||||:||||||||||||||||||:||||||.|||||.|||||:|.:::.:
Mouse    70 SDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAV 134

  Fly   132 NWGGGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSF 196
            ||.||||||||||||||||||||||.|||||||||||||||||:|||||||||||||||||||||
Mouse   135 NWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSF 199

  Fly   197 HKYGEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGA 261
            |||||||||||||||||||||||||||.|:|||:||::|..||.||||||||.:||:||||||||
Mouse   200 HKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGA 264

  Fly   262 DSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANEL 326
            |||:||||||||||||||.||||.||.:|||.||:||||||||||:|||||||:|||..||.|||
Mouse   265 DSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNEL 329

  Fly   327 PYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDES 391
            |||||||||||||||||||||||||||.||:||||.||||||||||||||||:|||||||::::|
Mouse   330 PYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDS 394

  Fly   392 DDEDKVDKDDRLPQSDKDKRIVPENEYSDSEDEGEGGRRDNRSYKGQRKRPRLDKDTNSNKASSE 456
            .|||..|.|.|:.....||||..:.|:||||||||||||:...:|...|:.|:::|   .|.:.:
Mouse   395 GDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEED---KKETED 456

  Fly   457 TSSEIKDEKEKGDGADGEESTASNTNSNNNSN 488
            ..:::|:|.:..|.: ||::......|...||
Mouse   457 KKTDVKEEDKSKDNS-GEKTDPKGAKSEQLSN 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:450134	319/366 (87%)
Hdac2	NP_032255.2	HDAC2	9..374	CDD:212535	318/364 (87%)
		Histone deacetylase	9..322		272/312 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..488		38/103 (37%)