Protein Alignment HDAC1 and Hdac6

DIOPT Version :10

• Sequence 1: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_063135796.1
• Gene: Hdac6 / 108348065
• RGDID: 619981
• Length: 1164
• Species: Rattus norvegicus
• Alignment Length: 564
• Identity: 133/564 - (23%)
• Similarity: 219/564 - (38%)
• Gaps: 122/564 - (21%)

  Fly     1 MQSHSKKRVCYYYDSDIGNYYYGQGHPMKPHRIR--MTHNLLLNYGLYRKMEIYRPHKATADEMT 63
            |.||     |..:|:.         ||..|.||.  |.|  |...||..:..|.....|...|:.
  Rat   488 MMSH-----CNLWDNH---------HPETPQRILRIMCH--LEEVGLAARCLILPARPALDSELL 536

  Fly    64 KFHSDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGS--VAAAVKLNKQA 126
            ..||.|||..||:.......:.:::...|.....||   ..:...||:.|.:  :..||...:..
  Rat   537 TCHSAEYVERLRATEKMKTRDLHREGANFESIYICP---STFACAQLATGAACRLVEAVLSGEVL 598

  Fly   127 SEICINWGGGLHHAKKSEASGFCYVNDIVLGILELLKYHQ-------RVLYIDIDVHHGDGVEEA 184
            :.|.|....| |||:...|.|||:.|.:.:.    .::.|       |:|.:|.|||||:|.:..
  Rat   599 NGIAIVRPPG-HHAEPDAACGFCFFNSVAVA----ARHAQVIAGRALRILIVDWDVHHGNGTQHI 658

  Fly   185 FYTTDRVMTVSFHKY--GEYFP--GTGDLRDIGAGKGKYYAVNIPLR-DGMDDDAYESIFVPIIS 244
            |.....|:.||.|:|  |.:||  ..|....:|...|..:.||:|.. ..|.|..|.:.:..::.
  Rat   659 FEEDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRAAGTGFTVNVPWNGPRMGDADYLATWHRLVL 723

  Fly   245 KVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVG----------GG 299
            .:...|.|..|::..|.|:..||.||...:|.:|:.         :|..|::|          .|
  Rat   724 PIAYEFNPELVLISAGFDAAQGDPLGGCQVTPEGYA---------HLTHLLMGLAGGRIILILEG 779

  Fly   300 GYTIRNVSRCWTYETSVALAVEIANELPYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRL 364
            ||.:.::|     |:..|....:..:.|         |.......|.:....:.||.:: :..:.
  Rat   780 GYNLTSIS-----ESMAACTHSLLGDPP---------PQLTSLRPPQSGALASISEVIQ-VHRKY 829

  Fly   365 FENLRMLPHAPGVQIQAIPEDAINDESDDEDKVDKDD------RLPQSDKDKRIVPENEYSDSED 423
            :.:||::..                    |||.::..      :||||..     |.:....:..
  Rat   830 WRSLRLMKM--------------------EDKEERSSSRLVIKKLPQSAS-----PVSAKGMTTP 869

  Fly   424 EG---EGGRR-------DNRSYKGQRK----RPRLDKDTNSNKASSETSSEIKDEKEKGDGADGE 474
            :|   |.|.|       ...|..||.|    :..|.:..:|.:|:..|:.::...|:...||..:
  Rat   870 KGKVLEAGMRKPTAALPTKESTLGQAKAKTAKALLAQGQSSEQAAKGTTLDLATSKDTVGGATTD 934

  Fly   475 E--STASNTNSNNNSNNKSDNDAGATANAGSGSGSGSGAGAKGA 516
            :  |.|:..||.|.:.: .:..:|.|.:.|:...|.:.....||
  Rat   935 QCASVAATENSANQTTS-GEEASGETESFGTSPSSNASKQTTGA 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:450134	96/392 (24%)
Hdac6	XP_063135796.1	None