DRSC/TRiP Functional Genomics Resources

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Protein Alignment HDAC1 and HDAC5

DIOPT Version :10

Sequence 1:NP_647918.2 Gene:HDAC1 / 38565 FlyBaseID:FBgn0015805 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_001015053.1 Gene:HDAC5 / 10014 HGNCID:14068 Length:1123 Species:Homo sapiens


Alignment Length:86 Identity:17/86 - (19%)
Similarity:38/86 - (44%) Gaps:20/86 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   574 MREKNVKKEPGQSWIKWKGKLHSFSADDESSPYL--DQIYAKL----EELNNKIIDN-----GYK 627
            :::::.|||.         .|....||.|...|:  .::.:||    |:|.:|.:|:     |.:
Human     5 IKQEDPKKEI---------LLAMLMADKEKKGYIMASELRSKLMKLGEKLTHKEVDDLFKEAGIE 60

  Fly   628 PDTSFVHHDVEEAVKVKMLNY 648
            |:....:....:.:.:.:.:|
Human    61 PNGQVKYDTFIQRITIPVRDY 81

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC1NP_647918.2 Arginase_HDAC 5..372 CDD:450134
HDAC5NP_001015053.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..61 5/18 (28%)
ClassIIa_HDAC5_Gln-rich-N 69..165 CDD:197400 1/13 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 197..282
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 303..344
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 482..505
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..626
HDAC5 680..1096 CDD:212531
Histone deacetylase 685..1029
Nuclear export signal 1082..1123
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1098..1123
Blue background indicates that the domain is not in the aligned region.

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