DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC1 and HDAC6

DIOPT Version :9

Sequence 1:	NP_647918.2	Gene:	HDAC1 / 38565	FlyBaseID:	FBgn0015805	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001308154.1	Gene:	HDAC6 / 10013	HGNCID:	14064	Length:	1229	Species:	Homo sapiens

Alignment Length:	566	Identity:	127/566 - (22%)
Similarity:	219/566 - (38%)	Gaps:	113/566 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KKRVCYYYDSDIGNY--YYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSD 68
            :.|....||.::.|:  .:...||..|.||......|...||..:.....|..||..|:...||.
Human   492 QSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSA 556

  Fly    69 EYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINW 133
            |||..||:.......|.:::...|:....||   ..:...||:.|   ||...:....|...:|
Human   557 EYVGHLRATEKMKTRELHRESSNFDSIYICP---STFACAQLATG---AACRLVEAVLSGEVLN- 614

  Fly   134 GGGL-----HHAKKSEASGFCYVNDIVLGI--LELLKYHQ-RVLYIDIDVHHGDGVEEAFYTTDR 190
            |..:     |||::..|.|||:.|.:.:..  .:.:..|. |:|.:|.|||||:|.:..|.....
Human   615 GAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPS 679

  Fly   191 VMTVSFHKY--GEYFP--GTGDLRDIGAGKGKYYAVNIPLR-DGMDDDAYESIFVPIISKVMETF 250
            |:.||.|:|  |.:||  ..|....||...|..:.||:... ..|.|..|.:.:..::..:...|
Human   680 VLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEF 744

  Fly   251 QPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVG----------GGGYTIRN 305
            .|..|::..|.|:..||.||...::.:|:.         :|..|::|          .|||.:.:
Human   745 NPELVLVSAGFDAARGDPLGGCQVSPEGYA---------HLTHLLMGLASGRIILILEGGYNLTS 800

  Fly   306 VSRCWTYETSVALAVEIANELPYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRM 370
            :|     |:..|....:..:.|         |...|...|.:....:.:|.:: :..|.:.:||:
Human   801 IS-----ESMAACTRSLLGDPP---------PLLTLPRPPLSGALASITETIQ-VHRRYWRSLRV 850

  Fly   371 L-------PHAPGVQIQAIPEDAINDESDDEDKVDKDDRLPQ--SDKDKRIVPENEYSDSEDEGE 426
            :       |.:..:..:..|:.|             ..||.:  :.::|:::          |..
Human   851 MKVEDREGPSSSKLVTKKAPQPA-------------KPRLAERMTTREKKVL----------EAG 892

  Fly   427 GGRRDNRSYKGQRKRP----------RLDKDTNSNKAS-----SETSSEI---------KDEKEK 467
            .|:..:.|: |:...|          .|.:|..|..|:     ::|.||.         ...:|.
Human   893 MGKVTSASF-GEESTPGQTNSETAVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEA 956

  Fly   468 GDGADGEESTASNTNSNNNSNNKSDNDAGATANAGSGSGSGSGAGA 513
            ..||..:::|:..|......:..:..||...|..|..:...:..||
Human   957 VGGATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGA 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	98/397 (25%)
HDAC6	NP_001308154.1	HDAC6-dom1	113..449	CDD:212545
		HDAC6-dom2	499..849	CDD:212527	95/380 (25%)
		zf-UBP	1147..1209	CDD:280334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810