DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42540 and STOML2

DIOPT Version :9

Sequence 1:	NP_001246627.1	Gene:	CG42540 / 38562	FlyBaseID:	FBgn0260657	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_038470.1	Gene:	STOML2 / 30968	HGNCID:	14559	Length:	356	Species:	Homo sapiens

Alignment Length:	317	Identity:	82/317 - (25%)
Similarity:	146/317 - (46%)	Gaps:	68/317 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 AEARRDTQAKHSHGFLYSDEEISDKASTCGKLLIFLSVALVIMTLPFSLFVCFKVVQEYERAVIF 222
            |.|.|.|.|....|.|.:......:||:               .||.:..|.|  |.:.|..|:.
Human     3 ARAARGTGALLLRGSLLASGRAPRRASS---------------GLPRNTVVLF--VPQQEAWVVE 50

  Fly   223 RLGRLMQGGAKGPGIFFILPCIDSYARV-DLRTRTYDVPPQEVLTKDSVTVSVDAVVYYRVSNAT 286
            |:||..:  ...||:..::|.:|....| .|:....:||.|..:|.|:||:.:|.|:|.|:.:..
Human    51 RMGRFHR--ILEPGLNILIPVLDRIRYVQSLKEIVINVPEQSAVTLDNVTLQIDGVLYLRIMDPY 113

  Fly   287 VSIANVENAHHSTRLLAQTTLRNTMGTRHLHEILSERMTISGTMQVQLDEATDAWGIKVERVEIK 351
            .:...||:..::...|||||:|:.:|...|.::..||.:::.::...:::|.|.|||:..|.|||
Human   114 KASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNASIVDAINQAADCWGIRCLRYEIK 178

  Fly   352 DVRLPVQLQRAMAAEAEAAREARAKVIAAEGEQKA------------------------SRALRE 392
            |:.:|.:::.:|..:.||.|..||.|:.:||.:::                        ::|..|
Human   179 DIHVPPRVKESMQMQVEAERRKRATVLESEGTRESAINVAEGKKQAQILASEAEKAEQINQAAGE 243

  Fly   393 ASEVI---------------------GDSPAALQL--RYLQTLNTISAEKNSTIVFP 426
            ||.|:                     ||:.|:|.:  :|:...:.::.:.| ||:.|
Human   244 ASAVLAKAKAKAEAIRILAAALTQHNGDAAASLTVAEQYVSAFSKLAKDSN-TILLP 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42540	NP_001246627.1	HflC	188..440	CDD:223407	73/287 (25%)
CG42540	NP_001246627.1	SPFH_stomatin	229..430	CDD:259801	63/246 (26%)
STOML2	NP_038470.1	HflC	41..314	CDD:223407	69/262 (26%)
		SPFH_paraslipin	74..184	CDD:259811	35/109 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..356
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810