DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42540 and Nphs2

DIOPT Version :9

Sequence 1:	NP_001246627.1	Gene:	CG42540 / 38562	FlyBaseID:	FBgn0260657	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_569723.1	Gene:	Nphs2 / 170484	MGIID:	2157018	Length:	385	Species:	Mus musculus

Alignment Length:	248	Identity:	129/248 - (52%)
Similarity:	182/248 - (73%)	Gaps:	0/248 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 CGKLLIFLSVALVIMTLPFSLFVCFKVVQEYERAVIFRLGRLMQGGAKGPGIFFILPCIDSYARV 250
            |..||:..|:..:|||.|||::.|.||||||||.:|||||.|:.|.|||||:||.|||:|:|.:|
Mouse   103 CEWLLVLASLIFIIMTFPFSIWFCIKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDTYHKV 167

  Fly   251 DLRTRTYDVPPQEVLTKDSVTVSVDAVVYYRVSNATVSIANVENAHHSTRLLAQTTLRNTMGTRH 315
            |||.:|.::|..||:|||...:.:|||.|||:.||::.::::.:...:.:.|.|||::..:..|.
Mouse   168 DLRLQTLEIPFHEVVTKDMFIMEIDAVCYYRMENASLLLSSLAHVSKAIQFLVQTTMKRLLAHRS 232

  Fly   316 LHEILSERMTISGTMQVQLDEATDAWGIKVERVEIKDVRLPVQLQRAMAAEAEAAREARAKVIAA 380
            |.|||.||.:|:..::|.||..|..|||||||.||||||||..||.::|.||||.|:|:.:||||
Mouse   233 LTEILLERKSIAQDVKVALDAVTCIWGIKVERTEIKDVRLPAGLQHSLAVEAEAQRQAKVRVIAA 297

  Fly   381 EGEQKASRALREASEVIGDSPAALQLRYLQTLNTISAEKNSTIVFPLPIDLIT 433
            |||:.||.:||.|:|::..:|||:|||||.||.::|.||.:|:|.|||.|:::
Mouse   298 EGEKAASESLRMAAEILSGTPAAVQLRYLHTLQSLSTEKPATVVLPLPFDMLS 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42540	NP_001246627.1	HflC	188..440	CDD:223407	128/246 (52%)
CG42540	NP_001246627.1	SPFH_stomatin	229..430	CDD:259801	103/200 (52%)
Nphs2	NP_569723.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		SPFH_podocin	124..346	CDD:259809	117/221 (53%)
		PHB	125..289	CDD:214581	85/163 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..385
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000760
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10264
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910