Protein Alignment CG42540 and PHB2

DIOPT Version :9

• Sequence 1: NP_001246627.1
• Gene: CG42540 / 38562
• FlyBaseID: FBgn0260657
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_001138303.1
• Gene: PHB2 / 11331
• HGNCID: 30306
• Length: 299
• Species: Homo sapiens
• Alignment Length: 258
• Identity: 55/258 - (21%)
• Similarity: 109/258 - (42%)
• Gaps: 49/258 - (18%)

  Fly   189 LLIFLSVALVIMTLPFSLFVCFKVVQEYERAVIF-RLGRLMQGGAKGPGIFFILPCIDSYARVDL 252
            |.:.|....|...:..|:|    .|:...||:.| |:|.:.|......|:.|.:|........|:
Human    23 LKLLLGAGAVAYGVRESVF----TVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDI 83

  Fly   253 RTRTYDVPPQEVLTKDSVTVSVDAVVYYRVSNATVSIANVENAH------------HSTRLL--- 302
            |.|     |:::   .|.|.|.|    .::.|.::.:.:..||.            :..|:|
Human    84 RAR-----PRKI---SSPTGSKD----LQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSI 136

  Fly   303 AQTTLRNTMGTRHLHEILSERMTISGTMQVQLDEATDAWGIKVERVEIKDVRL------------ 355
            ....|::.:...:..:::::|..:|..::.:|.|....:.:.::.|.|.::..
Human   137 VNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQ 201

  Fly   356 --PVQLQRAMAAEAEAAREARAKVIAAEGEQKASRALREASEVIGDSPAALQLRYLQTLNTIS 416
              ..:.|||.....:|.:|.|.|::.||||.:|::.|.||   :..:|..::||.::....||
Human   202 VAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEA---LSKNPGYIKLRKIRAAQNIS 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42540	NP_001246627.1	HflC	188..440	CDD:223407	55/258 (21%)
		SPFH_stomatin	229..430	CDD:259801	44/217 (20%)
PHB2	NP_001138303.1	Necessary for transcriptional repression. /evidence=ECO:0000269|PubMed:10359819	19..49		6/29 (21%)
		SPFH_prohibitin	40..235	CDD:259799	42/210 (20%)
		LC3-interaction region. /evidence=ECO:0000269|PubMed:28017329	121..124		0/2 (0%)
		Necessary for transcriptional repression. /evidence=ECO:0000269|PubMed:10359819	150..174		4/23 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810