Protein Alignment KRT8 and LamC

DIOPT Version :9

• Sequence 1: NP_001243211.1
• Gene: KRT8 / 3856
• HGNCID: 6446
• Length: 511
• Species: Homo sapiens
• Sequence 2: NP_001260974.1
• Gene: LamC / 36615
• FlyBaseID: FBgn0010397
• Length: 640
• Species: Drosophila melanogaster
• Alignment Length: 507
• Identity: 136/507 - (26%)
• Similarity: 228/507 - (44%)
• Gaps: 113/507 - (22%)

Human    50 SRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTVNQSLLSPLVLEVDPNIQA 114
            ||:.||.|....|:|  ||||::                          |..||        .:.
  Fly    13 SRASTSTPVGGASTS--SRVGAT--------------------------SPTSP--------TRT 41

Human   115 VRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQ-KTARSNMDNMFESYINNLRRQ 178
            .|.||||:::.||::.|.:||::|.||.:|..|..:.:|.|.. ....||:..::|..:...|:.
  Fly    42 SRQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKL 106

Human   179 LETLGQEKLKLEAELGNMQGLVEDFK---------------------NKYEDEIN---------- 212
            |:...:||.|||.::..:....:|.|                     |:| :|:|
  Fly   107 LDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRY-NEVNGKYNQSLADR 170

Human   213 -------KRTEMENEFVL-----IKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQS 265
                   |...:|||.:.     ::|.::...:.:|:||::.:.|.:|:.|..|::.:|:.|.:|
  Fly   171 KKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRS 235

Human   266 ----QISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGD 326
                :||:....||......|...  :.|::.|||.....:|.|.|.:|..:.:.|::.|.:...
  Fly   236 RRQIEISEIDGRLSRQYEAKLQQS--LQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQ 298

Human   327 DLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRA 391
            .......|:..|...|..|.|:::.|:...|.|.|.|.:.|...:...:..|..::.|||.|||.
  Fly   299 GSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRM 363

Human   392 KQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRL----------ESGMQNMSIH-TKTTS 445
            :.:||.||:|||.||::|::||:|||.|.|||.|||.||          :||:.:...| |.:.|
  Fly   364 RDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSNGSHLTASAS 428

Human   446 GYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETR 497
            ..:|.::.:.....:||:|           |||:..|    |..|:.:.|.|
  Fly   429 SRSGRVTPSGRRSATPGIS-----------GSSAVKR----RRTVIDESEDR 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KRT8	NP_001243211.1	Keratin_2_head	<91..115	CDD:292825	3/23 (13%)
		Filament	118..429	CDD:278467	102/358 (28%)
		HAUS2	315..>404	CDD:291664	26/88 (30%)
LamC	NP_001260974.1	Filament	45..401	CDD:278467	102/358 (28%)
		ATP-synt_B	<67..>142	CDD:304375	18/74 (24%)
		MreC	<178..>224	CDD:302802	11/45 (24%)
		LTD	473..574	CDD:279300

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910